Search Results - "Bisetto, Sara"

Loss of Sirt1 Promotes Prostatic Intraepithelial Neoplasia, Reduces Mitophagy, and Delays Park2 Translocation to Mitochondria by Di Sante, Gabriele, Pestell, Timothy G, Casimiro, Mathew C, Bisetto, Sara, Powell, Michael J, Lisanti, Michael P, Cordon-Cardo, Carlos, Castillo-Martin, Mireia, Bonal, Dennis M, Debattisti, Valentina, Chen, Ke, Wang, Liping, He, Xiaohong, McBurney, Michael W, Pestell, Richard G

“…Prostatic intraepithelial neoplasia is a precursor to prostate cancer. Herein, deletion of the NAD+ -dependent histone deacetylase Sirt1 induced histological…”
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Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer by Bisetto, Sara, Whitaker-Menezes, Diana, Wilski, Nicole A, Tuluc, Madalina, Curry, Joseph, Zhan, Tingting, Snyder, Christopher M, Martinez-Outschoorn, Ubaldo E, Philp, Nancy J

“…Head and neck squamous cell carcinoma (HNSCC) is the 6th most common human cancer and affects approximately 50,000 new patients every year in the US. The major…”
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Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts by O-Uchi, Jin, Jhun, Bong Sook, Hurst, Stephen, Bisetto, Sara, Gross, Polina, Chen, Ming, Kettlewell, Sarah, Park, Jongsun, Oyamada, Hideto, Smith, Godfrey L, Murayama, Takashi, Sheu, Shey-Shing

“…Ca(+) influx to mitochondria is an important trigger for both mitochondrial dynamics and ATP generation in various cell types, including cardiac cells…”
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New Insights into the Lactate Shuttle: Role of MCT4 in the Modulation of the Exercise Capacity by Bisetto, Sara, Wright, Megan C., Nowak, Romana A., Lepore, Angelo C., Khurana, Tejvir S., Loro, Emanuele, Philp, Nancy J.

“…Lactate produced by muscle during high-intensity activity is an important end product of glycolysis that supports whole body metabolism. The lactate shuttle…”
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A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration by Zhang, Huiliang, Wang, Pei, Bisetto, Sara, Yoon, Yisang, Chen, Quan, Sheu, Shey-Shing, Wang, Wang

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A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration by Zhang, Huiliang, Wang, Pei, Bisetto, Sara, Yoon, Yisang, Chen, Quan, Sheu, Shey-Shing, Wang, Wang

“…Mitochondria in adult cardiomyocytes exhibit static morphology and infrequent dynamic changes, despite the high abundance of fission and fusion regulatory…”
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Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA by Loro, Emanuele, Bisetto, Sara, Khurana, Tejvir S

“…The pro-inflammatory cytokine interleukin-15 (IL15) and its receptor α (IL15RA) participate in the regulation of musculoskeletal function and metabolism…”
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A cellular hierarchy of Notch and Kras signaling controls cell fate specification in the developing mouse salivary gland by Chatzeli, Lemonia, Bordeu, Ignacio, Han, Seungmin, Bisetto, Sara, Waheed, Zahra, Koo, Bon-Kyoung, Alcolea, Maria P, Simons, Benjamin D

“…The development of the mouse salivary gland involves a tip-driven process of branching morphogenesis that takes place in concert with differentiation into…”
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Lactate Efflux From Intervertebral Disc Cells Is Required for Maintenance of Spine Health by Silagi, Elizabeth S, Novais, Emanuel J, Bisetto, Sara, Telonis, Aristeidis G, Snuggs, Joseph, Le Maitre, Christine L, Qiu, Yunping, Kurland, Irwin J, Shapiro, Irving M, Philp, Nancy J, Risbud, Makarand V

“…ABSTRACT Maintenance of glycolytic metabolism is postulated to be required for health of the spinal column. In the hypoxic tissues of the intervertebral disc…”
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Role of monocarboxylate transporters in regulating metabolic homeostasis in the outer retina: Insight gained from cell‐specific Bsg deletion by Han, John Y. S., Kinoshita, Junzo, Bisetto, Sara, Bell, Brent A., Nowak, Romana A., Peachey, Neal S., Philp, Nancy J.

“…The neural retina metabolizes glucose through aerobic glycolysis generating large amounts of lactate. Lactate flux into and out of cells is regulated by…”
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Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity by Rouleau, Lauren, Antony, Anil Noronha, Bisetto, Sara, Newberg, Andrew, Doria, Cataldo, Levine, Mark, Monti, Daniel A., Hoek, Jan B.

“…We investigated the mechanism of selective ascorbate-induced cytotoxicity in tumor cells, including Hep G2 cells, compared to primary hepatocytes. H2O2…”
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Abstract 391: Endogenous Drp1 Modulates Cardiac Respiration Through mPTP and Independent of Fission by Zhang, Huiliang, Bisetto, Sara, Sheu, Shey-Shing, Wang, Wang

“…Abstract only Background: The cardiac mitochondria exhibit a stable morphology with a rather low level of dynamic changes. However, fission and fusion…”
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Downregulation of adenine nucleotide translocator 1 exacerbates tumor necrosis factor-α-mediated cardiac inflammatory responses by Pan, Shi, Wang, Nadan, Bisetto, Sara, Yi, Bing, Sheu, Shey-Shing

“…Inflammation contributes significantly to cardiac dysfunction. Although the initial phase of inflammation is essential for repair and healing, excessive…”
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New Insights into the Lactate Shuttle: Lesson Learned from the MCT4 Knock Out Mouse by Bisetto, Sara

“…For a long time, lactate has been considered just a waste by-product of anaerobic glycolysis and cause of muscle fatigue after intense exercise. Extensive…”
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Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis by Casimiro, Mathew C, Di Sante, Gabriele, Di Rocco, Agnese, Loro, Emanuele, Pupo, Claudia, Pestell, Timothy G, Bisetto, Sara, Velasco-Velázquez, Marco A, Jiao, Xuanmao, Li, Zhiping, Kusminski, Christine M, Seifert, Erin L, Wang, Chenguang, Ly, Daniel, Zheng, Bin, Shen, Che-Hung, Scherer, Philipp E, Pestell, Richard G

“…Autophagy activated after DNA damage or other stresses mitigates cellular damage by removing damaged proteins, lipids, and organelles. Activation of the master…”
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Abstract B10: Cyclin D1 restrains oncogene-induced autophagy via phosphorylation of LKB1 by Casimiro, Mathew, Sante, Gabriele Di, Loro, Emanuele, Pestell, Timothy, Bisetto, Sara, Velasco-Velázquez, Marco, Jiao, Xuanmao, Li, Zhiping, Wang, Chenguang, Ly, Daniel, Zheng, Bin, Che-Hung, Shen, Ertel, Adam, Pestell, Richard G.

“…Abstract Cyclin D1 is an important molecular driver of many human cancers. The cyclin D1 gene is amplified or overexpressed in up to half of human breast…”
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Abstract LB-133: A novel tumor suppressor role for sirt1 inhibiting mitophagy in prostate mouse tissue by Sante, Gabriele Di, Wang, Liping, Wang, Chenguang, Bisetto, Sara, Casimiro, Mathew C, Powell, Michael, McBurney, Michael, Pestell, Richard

“…Abstract Introduction. Sirtuin family consists of NAD+-dependent class III histone deacetylases (HDACs). Sirtuin family members (SIRT1-SIRT7) were shown to…”
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