Search Results - "Biscoe, Mark R"

Enantiodivergent Pd-catalyzed C-C bond formation enabled through ligand parameterization by Zhao, Shibin, Gensch, Tobias, Murray, Benjamin, Niemeyer, Zachary L, Sigman, Matthew S, Biscoe, Mark R

“…Despite the enormous potential for the use of stereospecific cross-coupling reactions to rationally manipulate the three-dimensional structure of organic…”
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Stereospecific Pd-Catalyzed Cross-Coupling Reactions of Secondary Alkylboron Nucleophiles and Aryl Chlorides by Li, Ling, Zhao, Shibin, Joshi-Pangu, Amruta, Diane, Mohamed, Biscoe, Mark R

“…We report the development of a Pd-catalyzed process for the stereospecific cross-coupling of unactivated secondary alkylboron nucleophiles and aryl chlorides…”
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Stereoselectivity in Pd-catalysed cross-coupling reactions of enantioenriched nucleophiles by Ma, Xinghua, Murray, Benjamin, Biscoe, Mark R.

“…Advances in Pd-catalysed cross-coupling reactions have facilitated the development of stereospecific variants enabling the use of configurationally stable,…”
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A Highly Active Catalyst for Pd-Catalyzed Amination Reactions: Cross-Coupling Reactions Using Aryl Mesylates and the Highly Selective Monoarylation of Primary Amines Using Aryl Chlorides by Fors, Brett P, Watson, Donald A, Biscoe, Mark R, Buchwald, Stephen L

“…A catalyst system based on a new biarylmonophosphine ligand (BrettPhos) that shows excellent reactivity for C−N cross-coupling reactions is reported. This…”
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Nickel-Catalyzed Kumada Cross-Coupling Reactions of Tertiary Alkylmagnesium Halides and Aryl Bromides/Triflates by Joshi-Pangu, Amruta, Wang, Chao-Yuan, Biscoe, Mark R

“…We report a Ni-catalyzed process for the cross-coupling of tertiary alkyl nucleophiles and aryl bromides. This process is extremely general for a wide range of…”
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Configurationally stable, enantioenriched organometallic nucleophiles in stereospecific Pd-catalyzed cross-coupling reactions: an alternative approach to asymmetric synthesis by Wang, Chao-Yuan, Derosa, Joseph, Biscoe, Mark R

“…Several research groups have recently developed methods to employ configurationally stable, enantioenriched organometallic nucleophiles in stereospecific…”
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A New Class of Easily Activated Palladium Precatalysts for Facile C−N Cross-Coupling Reactions and the Low Temperature Oxidative Addition of Aryl Chlorides by Biscoe, Mark R, Fors, Brett P, Buchwald, Stephen L

“…A new class of one-component Pd precatalysts bearing biarylphosphine ligands is described. These precatalysts are air- and thermally stable, are easily…”
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Nickel-Catalyzed Negishi Cross-Coupling Reactions of Secondary Alkylzinc Halides and Aryl Iodides by Joshi-Pangu, Amruta, Ganesh, Madhu, Biscoe, Mark R

“…A general Ni-catalyzed process for the cross-coupling of secondary alkylzinc halides and aryl/heteroaryl iodides has been developed. This is the first process…”
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Pd-Catalyzed Amidations of Aryl Chlorides Using Monodentate Biaryl Phosphine Ligands:  A Kinetic, Computational, and Synthetic Investigation by Ikawa, Takashi, Barder, Timothy E, Biscoe, Mark R, Buchwald, Stephen L

“…We present results on the amidation of aryl halides and sulfonates utilizing a monodentate biaryl phosphine-Pd catalyst. Our results are in accord with a…”
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Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides by Biscoe, Mark R, Buchwald, Stephen L

“…Simple, efficient procedures for the monoarylation of acetate esters and aryl methyl ketones using aryl chlorides are presented. Previously, no general method…”
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Electronic Effects on the Selectivity of Pd-Catalyzed C----N Bond-Forming Reactions Using Biarylphosphine Ligands: The Competitive Roles of Amine Binding and Acidity by Biscoe, Mark R, Barder, Timothy E, Buchwald, Stephen L

“…Electronic influence: Correlation between the relative binding constants of amines to isolated [SPhosPd(Ph)Cl]…”
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Simple, efficient protocols for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine by Lee, Brian K., Biscoe, Mark R., Buchwald, Stephen L.

“…Simple and efficient procedures for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine are described. At room temperature with a…”
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From Established to Emerging: Evolution of Cross-Coupling Reactions by Biscoe, Mark R., Cornella, Josep, Kalyani, Dipannita, Neufeldt, Sharon

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Oxaziridinium Salts as Hydrophobic Epoxidation Reagents:  Remarkable Hydrophobically-Directed Selectivity in Olefin Epoxidation by Biscoe, Mark R, Breslow, Ronald

“…Selective epoxidation of cinnamates versus crotonate was used to detect hydrophobic binding of the cinnamates in the transition states with hydrophobic…”
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Preparation of Enantioenriched Alkylcarbastannatranes via Nucleophilic Inversion of Alkyl Mesylates for Use in Stereospecific Cross-Coupling Reactions by Ralph, Glenn, Biscoe, Mark R

“…We report the preparation of enantioenriched secondary alkylcarbastannatranes via a stereoinvertive SN2 reaction of enantioenriched alkyl mesylates and…”
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A general approach to stereospecific Pd-catalyzed cross-coupling reactions of benzylic stereocenters by Binayeva, Meruyert, Ma, Xinghua, Ghaemimohammadi, Pejman, Biscoe, Mark R

“…We have developed a general process for the formation of enantioenriched benzylic stereocenters via stereospecific Pd-catalyzed cross-coupling reactions of…”
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Stereoretentive Pd-catalysed Stille cross-coupling reactions of secondary alkyl azastannatranes and aryl halides by Li, Ling, Wang, Chao-Yuan, Huang, Rongcai, Biscoe, Mark R.

“…The development of transition metal-catalysed cross-coupling reactions has greatly influenced the manner in which the synthesis of complex organic molecules is…”
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Pd-Catalyzed Arylation of Secondary α‑Alkoxytricyclohexylstannanes by Zhao, Haoran, Jose, Anju Treesa, Asany, Alisajat, Khan, Shahrukh M., Biscoe, Mark R.

“…We have developed a general process for the formation of α-arylethers via the Pd-catalyzed arylation of secondary α-alkoxytricyclohexylstannanes. Incorporation…”
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The Stereochemical Course of Pd-Catalyzed Suzuki Reactions Using Primary Alkyltrifluoroborate Nucleophiles by Murray, Benjamin, Zhao, Shibin, Aramini, James M, Wang, Hsin, Biscoe, Mark R

“…Using deuterium-labeled stereochemical probes, we show that primary alkyltrifluoroborate nucleophiles undergo transmetalation to palladium exclusively via a…”
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Stereospecific Electrophilic Fluorination of Alkylcarbastannatrane Reagents by Ma, Xinghua, Diane, Mohamed, Ralph, Glenn, Chen, Christine, Biscoe, Mark R.

“…We report the use of isolable primary and secondary alkylcarbastannatrane nucleophiles in site‐specific fluorination reactions. These reactions occur without…”
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