Search Results - "Bischof, Gerard N."

Networks of tau distribution in Alzheimer's disease by Hoenig, Merle C, Bischof, Gérard N, Seemiller, Joseph, Hammes, Jochen, Kukolja, Juraj, Onur, Özgür A, Jessen, Frank, Fliessbach, Klaus, Neumaier, Bernd, Fink, Gereon R, van Eimeren, Thilo, Drzezga, Alexander

“…See Whitwell (doi:10.1093/brain/awy001) for a scientific commentary on this article. The stereotypical anatomical propagation of tau pathology is indicative of…”
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Clinical validity of second-generation tau PET tracers as biomarkers for Alzheimer’s disease in the context of a structured 5-phase development framework by Bischof, Gérard N, Dodich, Alessandra, Boccardi, Marina, van Eimeren, Thilo, Festari, Cristina, Barthel, Henryk, Hansson, Oskar, Nordberg, Agneta, Ossenkoppele, Rik, Sabri, Osama, Giovanni, B Frisoni G, Garibotto, Valentina, Drzezga, Alexander

“…Purpose In 2017, the Geneva Alzheimer’s disease (AD) strategic biomarker roadmap initiative proposed a framework of the systematic validation AD biomarkers to…”
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Improved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [ 18 F]PI-2620 by Bischof, Gérard N, Brendel, Matthias, Barthel, Henryk, Theis, Hendrik, Barbe, Michael, Bartenstein, Peter, Claasen, Joseph, Danek, Adrian, Höglinger, Günter, Levin, Johannes, Marek, Ken, Neumaier, Bernd, Palleis, Carla, Patt, Marianne, Rullmann, Michael, Saur, Dorothee, Schroeter, Matthias L, Seibyl, John, Song, Mengmeng, Stephens, Andrew, Sabri, Osama, Drzezga, Alexander, van Eimeren, Thilo

“…We used a new data-driven methodology to identify a set of reference regions that enhanced the quantification of the SUV ratio of the second-generation tau…”
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Neural broadening or neural attenuation? Investigating age-related dedifferentiation in the face network in a large lifespan sample by Park, Joonkoo, Carp, Joshua, Kennedy, Kristen M, Rodrigue, Karen M, Bischof, Gerard N, Huang, Chih-Mao, Rieck, Jennifer R, Polk, Thad A, Park, Denise C

“…Previous studies have found that cortical responses to different stimuli become less distinctive as people get older. This age-related dedifferentiation may…”
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The strategic biomarker roadmap for the validation of Alzheimer’s diagnostic biomarkers: methodological update by Boccardi, Marina, Dodich, Alessandra, Albanese, Emiliano, Gayet-Ageron, Angèle, Festari, Cristina, Ashton, Nicholas J., Bischof, Gérard N., Chiotis, Konstantinos, Leuzy, Antoine, Wolters, Emma E., Walter, Martin A., Rabinovici, Gil D., Carrillo, Maria, Drzezga, Alexander, Hansson, Oskar, Nordberg, Agneta, Ossenkoppele, Rik, Villemagne, Victor L., Winblad, Bengt, Frisoni, Giovanni B., Garibotto, Valentina

“…Background The 2017 Alzheimer’s disease (AD) Strategic Biomarker Roadmap (SBR) structured the validation of AD diagnostic biomarkers into 5 phases,…”
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Explainable artificial intelligence identifies an AQP4 polymorphism-based risk score associated with brain amyloid burden by Beer, Simone, Elmenhorst, David, Bischof, Gerard N., Ramirez, Alfredo, Bauer, Andreas, Drzezga, Alexander

“…Aquaporin-4 (AQP4) is hypothesized to be a component of the glymphatic system, a pathway for removing brain interstitial solutes like amyloid-β (Aβ). Evidence…”
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Obesity and Aging: Consequences for Cognition, Brain Structure, and Brain Function by Bischof, Gérard N, Park, Denise C

“…This review focuses on the relationship between obesity and aging and how these interact to affect cognitive function. The topics covered are guided by the…”
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The Impact of Sustained Engagement on Cognitive Function in Older Adults: The Synapse Project by Park, Denise C., Lodi-Smith, Jennifer, Drew, Linda, Haber, Sara, Hebrank, Andrew, Bischof, Gérard N., Aamodt, Whitley

“…In the research reported here, we tested the hypothesis that sustained engagement in learning new skills that activated working memory, episodic memory, and…”
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Brain Trauma Imaging by Bischof, Gérard N, Cross, Donna J

“…Imaging of mild traumatic brain injury (TBI) using conventional techniques such as CT or MRI often results in no specific imaging correlation that would…”
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Subthreshold amyloid and its biological and clinical meaning: Long way ahead by Bischof, Gérard N, Jacobs, Heidi I.L

“…The development of in vivo imaging of the pathologic hallmark of Alzheimer disease (AD), β-amyloid (Aβ), altered the framing of its pathophysiology and…”
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Tau-imaging in neurodegeneration by Bischof, Gérard N., Endepols, Heike, van Eimeren, Thilo, Drzezga, Alexander

“…•The background on tau-pathology in neurodegeneration.•Available tau-tracers and their status of validation.•The purpose and interest in tau-imaging.•The…”
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Unique regional patterns of amyloid burden predict progression to prodromal and clinical stages of Alzheimer's disease by Pfeil, Julia, Hoenig, Merle C., Doering, Elena, van Eimeren, Thilo, Drzezga, Alexander, Bischof, Gérard N.

“…Although beta-amyloid (Aβ) positivity has shown to be associated with higher risk of progression to Alzheimer's disease (AD) in mild cognitive impairment…”
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Age trajectories of functional activation under conditions of low and high processing demands: An adult lifespan fMRI study of the aging brain by Kennedy, Kristen M., Rodrigue, Karen M., Bischof, Gérard N., Hebrank, Andrew C., Reuter-Lorenz, Patricia A., Park, Denise C.

“…We examined functional activation across the adult lifespan in 316 healthy adults aged 20–89years on a judgment task that, across conditions, drew upon both…”
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Early role of iron in modulating amyloid's association with neurodegeneration by Bilgel, Murat, Bischof, Gérard N.

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Tau aggregation following subcortical hemorrhage by Jaeger, Elena, Bischof, Gérard N., Onur, Oezguer A., Schlamann, Marc, Drzezga, Alexander

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In Vivo Measurement of Tau Depositions in Anti-IgLON5 Disease Using [18F]PI-2620 PET by Theis, Hendrik, Bischof, Gérard N, Brüggemann, Norbert, Dargvainiene, Justina, Drzezga, Alexander, Grüter, Thomas, Lewerenz, Jan, Leypoldt, Frank, Neumaier, Bernd, Wandinger, Klaus-Peter, Ayzenberg, Ilya, van Eimeren, Thilo

“…Anti-IgLON5 disease is a recently discovered neurologic disorder combining autoimmunity and neurodegeneration. Core manifestations include sleep disorders,…”
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Association of Longitudinal Cognitive Decline With Amyloid Burden in Middle-aged and Older Adults: Evidence for a Dose-Response Relationship by Farrell, Michelle E, Kennedy, Kristen M, Rodrigue, Karen M, Wig, Gagan, Bischof, Gérard N, Rieck, Jennifer R, Chen, Xi, Festini, Sara B, Devous, Sr, Michael D, Park, Denise C

“…Presently, the clinical standard for reporting the results of an amyloid positron emission tomography scan is to assign a dichotomous rating of positive or…”
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Elevated in vivo [18F]‐AV‐1451 uptake in a patient with progressive supranuclear palsy by Hammes, Jochen, Bischof, Gérard N., Giehl, Kathrin, Faber, Jennifer, Drzezga, Alexander, Klockgether, Thomas, Eimeren, Thilo

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Amyloid deposition in younger adults is linked to episodic memory performance by Bischof, Gérard N, Rodrigue, Karen M, Kennedy, Kristen M, Devous, Michael D, Park, Denise C

“…OBJECTIVE:To examine the relationship of β-amyloid (Aβ) deposition to episodic memory in younger (30–49 years), middle-older (50–69 years), and older adults…”
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In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease by Dronse, Julian, Fliessbach, Klaus, Bischof, Gérard N, von Reutern, Boris, Faber, Jennifer, Hammes, Jochen, Kuhnert, Georg, Neumaier, Bernd, Onur, Oezguer A, Kukolja, Juraj, van Eimeren, Thilo, Jessen, Frank, Fink, Gereon R, Klockgether, Thomas, Drzezga, Alexander

“…The clinical heterogeneity of Alzheimer's disease is not reflected in the rather diffuse cortical deposition of amyloid-β. We assessed the relationship between…”
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