The role of IL17 and IL17RA polymorphisms in lethal pandemic acute viral pneumonia (Influenza A virus H1N1 subtype)

The role of IL17 and IL17RA polymorphisms in lethal pandemic acute viral pneumonia (Influenza A virus H1N1 subtype)

Abstract Background The cytokines play an essential role in acute inflammatory processes, and the IL-17 may be responsible for ambiguous aspects, and the correlation with genetic polymorphisms could improve the search for this critical biomarker. Thus, this study aimed to evaluate the IL-17A and IL-...

Full description

Saved in:
Bibliographic Details
Published in:Surgical and experimental pathology Vol. 6; no. 1; pp. 1 - 11
Main Authors: Liberalesso, Vanessa Yumie Salomão Watanabe, Azevedo, Marina Luise Viola, Malaquias, Mineia Alessandra Scaranello, de Paula, Caroline Busatta Vaz, Nagashima, Seigo, de Souza, Daiane Gavlik, Neto, Plínio Cézar, Gouveia, Kauana Oliveira, Biscaro, Larissa Cristina, Giamberardino, Ana Luisa Garcia, Gonçalves, Gabrielle Tasso, Kondo, Thais Teles Soares, Raboni, Sonia Maria, Weiss, Isabelle, Machado-Souza, Cleber, de Noronha, Lucia
Format: Journal Article
Language:English
Published: London BioMed Central 08-02-2023
BMC
Subjects:
Adenoviruses
Bacterial infections
Biomarkers
Digitization
Disease
IL17A
IL17RA
Immunohistochemistry
Infections
Influenza
Influenza A virus H1N1 subtype
Intensive care
Pandemics
Pathogenesis
Pathophysiology
Pneumonia
Polymorphism
Proteins
Quantitative analysis
Respiratory syncytial virus
Scanners
Viruses
United States > US
Germany
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background The cytokines play an essential role in acute inflammatory processes, and the IL-17 may be responsible for ambiguous aspects, and the correlation with genetic polymorphisms could improve the search for this critical biomarker. Thus, this study aimed to evaluate the IL-17A and IL-17RA tissue expression and the polymorphisms that codified these proteins in a population that died of pandemic Influenza A virus H1N1 subtype compared to a non-pandemic Influenza virus population. Methods Necropsy lung samples immunohistochemistry was performed to assess the presence of IL-17A and IL-17RA in the pulmonary tissue. Eight single nucleotide polymorphisms were genotyped using TaqMan® technology. Results The Influenza A H1N1 pandemic group had higher tissue expression of IL-17A, higher neutrophil recruitment and shorter survival time between admission and death. Three single nucleotide polymorphisms conferred risk for pandemic influenza A H1N1, the AA genotype of rs3819025 G/A, the CC genotype of rs2241044 A/C, and the TT genotype of rs 2,241,043 C/T. Conclusions One IL17A polymorphism (rs381905) and two IL17RA polymorphisms (rs2241044 and rs2241043) represented biomarkers of worse prognosis in the population infected with pandemic influenza A H1N1. The greater tissue expression of IL-17A shows a Th17 polarization and highlights the aggressiveness of the pandemic influenza virus with its duality in the protection and pathogenesis of the pulmonary infectious process.
ISSN:2520-8454
2520-8454
DOI:10.1186/s42047-023-00126-0