Search Results - "Biscarini, Silvia"
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Non-coding RNAs in Nervous System Development and Disease
Published in Frontiers in cell and developmental biology (06-05-2020)“…The rapid advance of RNA sequencing technologies contributed to a deep understanding of transcriptome composition and has allowed the discovery of a large…”
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A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons
Published in Molecular neurobiology (01-10-2018)“…Mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). FUS is a multifunctional protein involved in the biogenesis and activity of…”
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Characterization of the lncRNA transcriptome in mESC-derived motor neurons: Implications for FUS-ALS
Published in Stem cell research (01-03-2018)“…Long non-coding RNAs (lncRNAs) are currently recognized as crucial players in nervous system development, function and pathology. In Amyotrophic Lateral…”
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A KO mouse model for the lncRNA Lhx1os produces motor neuron alterations and locomotor impairment
Published in iScience (20-01-2023)“…Here, we describe a conserved motor neuron-specific long non-coding RNA, Lhx1os, whose knockout in mice produces motor impairment and postnatal reduction of…”
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A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs
Published in The EMBO journal (04-07-2022)“…The transition from dividing progenitors to postmitotic motor neurons (MNs) is orchestrated by a series of events, which are mainly studied at the…”
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