Search Results - "Birukova, A"

Microtubules as Major Regulators of Endothelial Function: Implication for Lung Injury by Karki, Pratap, Birukova, Anna A

“…Endothelial dysfunction has been attributed as one of the major complications in COVID-19 patients, a global pandemic that has already caused over 4 million…”
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Measurement of local permeability at subcellular level in cell models of agonist- and ventilator-induced lung injury by Dubrovskyi, Oleksii, Birukova, Anna A, Birukov, Konstantin G

“…Alterations of cell monolayer integrity and increased vascular permeability are key to many pathologies, including atherosclerosis, stroke, lung injury,…”
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Role of truncated oxidized phospholipids in acute endothelial barrier dysfunction caused by particulate matter by Karki, Pratap, Meliton, Angelo, Shah, Alok, Tian, Yufeng, Ohmura, Tomomi, Sarich, Nicolene, Birukova, Anna A, Birukov, Konstantin G

“…Particulate matter (PM) air pollution is a global environmental health problem contributing to more severe lung inflammation and injury. However, the molecular…”
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Activation of Vascular Endothelial Growth Factor (VEGF) Receptor 2 Mediates Endothelial Permeability Caused by Cyclic Stretch by Tian, Yufeng, Gawlak, Grzegorz, O'Donnell, James J., Birukova, Anna A., Birukov, Konstantin G.

“…High tidal volume mechanical ventilation and the resultant excessive mechanical forces experienced by lung vascular endothelium are known to lead to increased…”
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Gap junction protein connexin43 exacerbates lung vascular permeability by O'Donnell, 3rd, James J, Birukova, Anna A, Beyer, Eric C, Birukov, Konstantin G

“…Increased vascular permeability causes pulmonary edema that impairs arterial oxygenation and thus contributes to morbidity and mortality associated with Acute…”
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Oxidative stress contributes to lung injury and barrier dysfunction via microtubule destabilization by Kratzer, Eric, Tian, Yufeng, Sarich, Nicolene, Wu, Tinghuai, Meliton, Angelo, Leff, Alan, Birukova, Anna A

“…Oxidative stress is an important part of host innate immune response to foreign pathogens, such as bacterial LPS, but excessive activation of redox signaling…”
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Mechanosensitive Rap1 activation promotes barrier function of lung vascular endothelium under cyclic stretch by Ke, Yunbo, Karki, Pratap, Zhang, Chenou, Li, Yue, Nguyen, Trang, Birukov, Konstantin G, Birukova, Anna A

“…Mechanical ventilation remains an imperative treatment for the patients with acute respiratory distress syndrome, but can also exacerbate lung injury. We have…”
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Alterations of lung microbiota in a mouse model of LPS-induced lung injury by Poroyko, Valeriy, Meng, Fanyong, Meliton, Angelo, Afonyushkin, Taras, Ulanov, Alexander, Semenyuk, Ekaterina, Latif, Omar, Tesic, Vera, Birukova, Anna A, Birukov, Konstantin G

“…Acute lung injury (ALI) and the more severe acute respiratory distress syndrome are common responses to a variety of infectious and noninfectious insults. We…”
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Elevated truncated oxidized phospholipids as a factor exacerbating ALI in the aging lungs by Ke, Yunbo, Karki, Pratap, Kim, Junghyun, Son, Sophia, Berdyshev, Evgeny, Bochkov, Valery N., Birukova, Anna A., Birukov, Konstantin G.

“…ABSTRACT As mechanisms controlling redox homeostasis become impaired with aging, exaggerated oxidant stress may cause disproportional oxidation of cell…”
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Rap-afadin axis in control of Rho signaling and endothelial barrier recovery by Birukova, Anna A, Tian, Xinyong, Tian, Yufeng, Higginbotham, Katherine, Birukov, Konstantin G

“…Activation of the Rho GTPase pathway determines endothelial cell (EC) hyperpermeability after injurious stimuli. To date, feedback mechanisms of Rho…”
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Microtubule‐dependent mechanism of anti‐inflammatory effect of SOCS1 in endothelial dysfunction and lung injury by Karki, Pratap, Cha, Boyoung, Zhang, Chen‐Ou, Li, Yue, Ke, Yunbo, Promnares, Kamoltip, Kaibuchi, Kozo, Yoshimura, Akihiko, Birukov, Konstantin G., Birukova, Anna A.

“…Suppressors of cytokine signaling (SOCS) provide negative regulation of inflammatory reaction. The role and precise cellular mechanisms of SOCS1 in control of…”
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Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction by Meng, Fanyong, Meliton, Angelo, Moldobaeva, Nurgul, Mutlu, Gokhan, Kawasaki, Yoshihiro, Akiyama, Tetsu, Birukova, Anna A

“…Increased vascular endothelial permeability and inflammation are major pathological mechanisms of pulmonary edema and its life-threatening complication, the…”
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Regulation of lung endothelial permeability and inflammatory responses by prostaglandin A2: role of EP4 receptor by Ohmura, Tomomi, Tian, Yufeng, Sarich, Nicolene, Ke, Yunbo, Meliton, Angelo, Shah, Alok S, Andreasson, Katrin, Birukov, Konstantin G, Birukova, Anna A

“…The role of prostaglandin A2 (PGA2) in modulation of vascular endothelial function is unknown. We investigated effects of PGA2 on pulmonary endothelial cell…”
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Endothelial barrier disruption and recovery is controlled by substrate stiffness by Birukova, Anna A., Tian, Xinyong, Cokic, Ivan, Beckham, Yvonne, Gardel, Margaret L., Birukov, Konstantin G.

“…Circulating barrier disruptive agonists bind specific cell membrane receptors and trigger signal transduction pathways leading to the activation of cell…”
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Prostaglandins PGE2 and PGI2 promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation by Birukova, Anna A., Zagranichnaya, Tatiana, Fu, Panfeng, Alekseeva, Elena, Chen, Weiguo, Jacobson, Jeffrey R., Birukov, Konstantin G.

“…Prostaglandin E2 (PGE2) and prostacyclin are lipid mediators produced by cyclooxygenase and implicated in the regulation of vascular function, wound repair,…”
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Effects of prostaglandin lipid mediators on agonist-induced lung endothelial permeability and inflammation by Ke, Yunbo, Oskolkova, Olga V, Sarich, Nicolene, Tian, Yufeng, Sitikov, Albert, Tulapurkar, Mohan E, Son, Sophia, Birukova, Anna A, Birukov, Konstantin G

“…Prostaglandins (PG), the products of cyclooxygenase-mediated conversion of arachidonic acid, become upregulated in many situations including allergic response,…”
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Microtubule dynamics control HGF-induced lung endothelial barrier enhancement by Tian, Xinyong, Tian, Yufeng, Moldobaeva, Nurgul, Sarich, Nicolene, Birukova, Anna A

“…Microtubules (MT) play a vital role in many cellular functions, but their role in peripheral actin cytoskeletal dynamics which is essential for control of…”
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Mechanotransduction by GEF-H1 as a novel mechanism of ventilator-induced vascular endothelial permeability by Birukova, Anna A, Fu, Panfeng, Xing, Junjie, Yakubov, Bakhtiyor, Cokic, Ivan, Birukov, Konstantin G

“…Pathological lung overdistention associated with mechanical ventilation at high tidal volumes (ventilator-induced lung injury; VILI) compromises endothelial…”
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Substrate stiffness-dependent exacerbation of endothelial permeability and inflammation: mechanisms and potential implications in ALI and PH (2017 Grover Conference Series) by Karki, Pratap, Birukova, Anna A.

“…The maintenance of endothelial barrier integrity is absolutely essential to prevent the vascular leak associated with pneumonia, pulmonary edema resulting from…”
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Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection by Birukova, Anna A., Zagranichnaya, Tatiana, Alekseeva, Elena, Bokoch, Gary M., Birukov, Konstantin G.

“…Acute lung injury, sepsis, lung inflammation, and ventilator‐induced lung injury are life‐threatening conditions associated with lung vascular barrier…”
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