Search Results - "Birsoy, Kıvanc"

Metabolic sensing and control in mitochondria by Liu, Yuyang, Birsoy, Kıvanç

“…Mitochondria are membrane-enclosed organelles with endosymbiotic origins, harboring independent genomes and a unique biochemical reaction network. To perform…”
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A mitochondrial gatekeeper that helps cells escape death by ferroptosis by Garcia-Bermudez, Javier, Birsoy, Kıvanç

“…Ferroptosis is a type of cell death driven by oxidative damage to lipid membranes. The discovery that organelles called mitochondria have an antioxidant system…”
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Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers by Soula, Mariluz, Weber, Ross A., Zilka, Omkar, Alwaseem, Hanan, La, Konnor, Yen, Frederick, Molina, Henrik, Garcia-Bermudez, Javier, Pratt, Derek A., Birsoy, Kıvanç

“…Cancer cells rewire their metabolism and rely on endogenous antioxidants to mitigate lethal oxidative damage to lipids. However, the metabolic processes that…”
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Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism by Chen, Walter W., Freinkman, Elizaveta, Wang, Tim, Birsoy, Kıvanç, Sabatini, David M.

“…Mitochondria house metabolic pathways that impact most aspects of cellular physiology. While metabolite profiling by mass spectrometry is widely applied at the…”
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Identification and characterization of essential genes in the human genome by Wang, Tim, Birsoy, Kivanç, Hughes, Nicholas W., Krupczak, Kevin M., Post, Yorick, Wei, Jenny J., Lander, Eric S., Sabatini, David M.

“…Large-scale genetic analysis of lethal phenotypes has elucidated the molecular underpinnings of many biological processes. Using the bacterial clustered…”
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An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis by Birsoy, Kıvanç, Wang, Tim, Chen, Walter W., Freinkman, Elizaveta, Abu-Remaileh, Monther, Sabatini, David M.

“…The mitochondrial electron transport chain (ETC) enables many metabolic processes, but why its inhibition suppresses cell proliferation is unclear. It is also…”
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The Transsulfuration Pathway Makes, the Tumor Takes by Weber, Ross, Birsoy, Kıvanç

“…Cells can take up cysteine or synthesize it de novo from methionine, but synthesis alone does not meet the high demands of cancer cells to proliferate. In this…”
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Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation by Weber, Ross A., Yen, Frederick S., Nicholson, Shirony P.V., Alwaseem, Hanan, Bayraktar, Erol C., Alam, Mohammad, Timson, Rebecca C., La, Konnor, Abu-Remaileh, Monther, Molina, Henrik, Birsoy, Kıvanç

“…The lysosome is an acidic multi-functional organelle with roles in macromolecular digestion, nutrient sensing, and signaling. However, why cells require acidic…”
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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides by Birsoy, Kıvanç, Possemato, Richard, Lorbeer, Franziska K., Bayraktar, Erol C., Thiru, Prathapan, Yucel, Burcu, Wang, Tim, Chen, Walter W., Clish, Clary B., Sabatini, David M.

“…New apparatus is used to maintain proliferating cancer cells in low-glucose conditions, demonstrating that mitochondrial oxidative phosphorylation (OXPHOS) is…”
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SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells by Wang, Ying, Yen, Frederick S., Zhu, Xiphias Ge, Timson, Rebecca C., Weber, Ross, Xing, Changrui, Liu, Yuyang, Allwein, Benjamin, Luo, Hanzhi, Yeh, Hsi-Wen, Heissel, Søren, Unlu, Gokhan, Gamazon, Eric R., Kharas, Michael G., Hite, Richard, Birsoy, Kıvanç

“…Glutathione (GSH) is a small-molecule thiol that is abundant in all eukaryotes and has key roles in oxidative metabolism 1 . Mitochondria, as the major site of…”
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A comparative perspective on lipid storage in animals by Birsoy, Kivanç, Festuccia, William T, Laplante, Mathieu

“…Lipid storage is an evolutionary conserved process that exists in all organisms from simple prokaryotes to humans. In Metazoa, long-term lipid accumulation is…”
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Identification of White Adipocyte Progenitor Cells In Vivo by Rodeheffer, Matthew S., Birsoy, Kıvanç, Friedman, Jeffrey M.

“…The increased white adipose tissue (WAT) mass associated with obesity is the result of both hyperplasia and hypertrophy of adipocytes. However, the mechanisms…”
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A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity by Grabiner, Brian C, Nardi, Valentina, Birsoy, Kıvanc, Possemato, Richard, Shen, Kuang, Sinha, Sumi, Jordan, Alexander, Beck, Andrew H, Sabatini, David M

“…Genes encoding components of the PI3K-AKT-mTOR signaling axis are frequently mutated in cancer, but few mutations have been characterized in MTOR, the gene…”
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NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis by Alvarez, Samantha W., Sviderskiy, Vladislav O., Terzi, Erdem M., Papagiannakopoulos, Thales, Moreira, Andre L., Adams, Sylvia, Sabatini, David M., Birsoy, Kıvanç, Possemato, Richard

“…Cancers growing in high-oxygen environments, such as lung adenocarcinomas, select for the iron–sulfur cluster synthesizing enzyme NFS1 to support malignant…”
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Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs by Minton, Denise R., Nam, Minwoo, McLaughlin, Daniel J., Shin, Jong, Bayraktar, Erol C., Alvarez, Samantha W., Sviderskiy, Vladislav O., Papagiannakopoulos, Thales, Sabatini, David M., Birsoy, Kıvanç, Possemato, Richard

“…Upon glucose restriction, eukaryotic cells upregulate oxidative metabolism to maintain homeostasis. Using genetic screens, we find that the mitochondrial…”
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Drugging ACAT1 for Cancer Therapy by Garcia-Bermudez, Javier, Birsoy, Kivanç

“…In this issue, Fan et al. (2016) show that oncogenic tyrosine kinases can promote glycolysis by phosphorylating and stabilizing the tetrameric form of…”
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Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death by Garcia-Bermudez, Javier, Baudrier, Lou, Bayraktar, Erol Can, Shen, Yihui, La, Konnor, Guarecuco, Rohiverth, Yucel, Burcu, Fiore, Danilo, Tavora, Bernardo, Freinkman, Elizaveta, Chan, Sze Ham, Lewis, Caroline, Min, Wei, Inghirami, Giorgio, Sabatini, David M., Birsoy, Kıvanç

“…Cholesterol is essential for cells to grow and proliferate. Normal mammalian cells meet their need for cholesterol through its uptake or de novo synthesis 1 ,…”
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Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours by Garcia-Bermudez, Javier, Baudrier, Lou, La, Konnor, Zhu, Xiphias Ge, Fidelin, Justine, Sviderskiy, Vladislav O., Papagiannakopoulos, Thales, Molina, Henrik, Snuderl, Matija, Lewis, Caroline A., Possemato, Richard L., Birsoy, Kıvanç

“…As oxygen is essential for many metabolic pathways, tumour hypoxia may impair cancer cell proliferation 1 – 4 . However, the limiting metabolites for…”
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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate by Pacold, Michael E, Brimacombe, Kyle R, Chan, Sze Ham, Rohde, Jason M, Lewis, Caroline A, Swier, Lotteke J Y M, Possemato, Richard, Chen, Walter W, Sullivan, Lucas B, Fiske, Brian P, Cho, Steve, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D, Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Wang, Amy Q, Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D, Vander Heiden, Matthew G, Shen, Min, Gray, Nathanael S, Boxer, Matthew B, Sabatini, David M

“…A quantitative high-throughput screen identified an inhibitor of phosphoglycerate dehydrogenase (PHGDH), a key enzyme for serine synthesis. This inhibitor…”
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STACKing the odds for discoveries by Soula, Mariluz, Birsoy, Kıvanç

“…Characterization of cell death kinetics identifies new on- and off-target small-molecule modulators of ferroptosis and reveals a role of amino acid metabolism…”
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