Search Results - "Birrell, Mark A."

A Single 9-Colour Flow Cytometric Method to Characterise Major Leukocyte Populations in the Rat: Validation in a Model of LPS-Induced Pulmonary Inflammation by Barnett-Vanes, Ashton, Sharrock, Anna, Birrell, Mark A, Rankin, Sara

“…The rat is a commonly used model for immunological investigation. Yet basic research and characterisation of leukocyte populations and sub-sets lags far behind…”
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Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate by Bonvini, Sara J., PhD, Birrell, Mark A., PhD, Grace, Megan S., PhD, Maher, Sarah A., PhD, Adcock, John J., PhD, Wortley, Michael A., PhD, Dubuis, Eric, PhD, Ching, Yee-Man, MRes, Ford, Anthony P., PhD, Shala, Fisnik, MD, Miralpeix, Montserrat, PhD, Tarrason, Gema, PhD, Smith, Jaclyn A., PhD, Belvisi, Maria G., PhD

“…Background Sensory nerves innervating the airways play an important role in regulating various cardiopulmonary functions, maintaining homeostasis under healthy…”
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The role of the NLRP3 inflammasome in the pathogenesis of airway disease by Birrell, Mark A, Eltom, Suffwan

“…The incidences of respiratory diseases like asthma and Chronic Obstructive Pulmonary Disease (COPD) are increasing dramatically. Significantly, there are…”
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Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death by Thurston, Teresa L. M., Matthews, Sophie A., Jennings, Elliott, Alix, Eric, Shao, Feng, Shenoy, Avinash R., Birrell, Mark A., Holden, David W.

“…Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of…”
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Novel airway smooth muscle-mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma by Bonvini, Sara J, Birrell, Mark A, Dubuis, Eric, Adcock, John J, Wortley, Michael A, Flajolet, Pauline, Bradding, Peter, Belvisi, Maria G

“…Mast cell-airway smooth muscle (ASM) interactions play a major role in the immunoglobulin (Ig)E- dependent bronchoconstriction seen in asthma but less is known…”
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Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype by Birrell, Mark A, Maher, Sarah A, Dekkak, Bilel, Jones, Victoria, Wong, Sissie, Brook, Peter, Belvisi, Maria G

“…Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory diseases of the airway. Current treatment options (long acting β-adrenoceptor…”
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Phagocytosis‐dependent activation of a TLR9–BTK–calcineurin–NFAT pathway co‐ordinates innate immunity to Aspergillus fumigatus by Herbst, Susanne, Shah, Anand, Mazon Moya, Maria, Marzola, Vanessa, Jensen, Barbara, Reed, Anna, Birrell, Mark A, Saijo, Shinobu, Mostowy, Serge, Shaunak, Sunil, Armstrong‐James, Darius

“…Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity…”
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DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease by Birch, Jodie, Anderson, Rhys K, Correia-Melo, Clara, Jurk, Diana, Hewitt, Graeme, Marques, Francisco Madeira, Green, Nicola J, Moisey, Elizabeth, Birrell, Mark A, Belvisi, Maria G, Black, Fiona, Taylor, John J, Fisher, Andrew J, De Soyza, Anthony, Passos, João F

“…Cellular senescence has been associated with the structural and functional decline observed during physiological lung aging and in chronic obstructive…”
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Mechanistic link between diesel exhaust particles and respiratory reflexes by Robinson, Ryan K., BSc, Birrell, Mark A., PhD, Adcock, John J., PhD, Wortley, Michael A., PhD, Dubuis, Eric D., PhD, Chen, Shu, PhD, McGilvery, Catriona M., PhD, Hu, Sheng, PhD, Shaffer, Milo S.P., PhD, Bonvini, Sara J., PhD, Maher, Sarah A., PhD, Mudway, Ian S., PhD, Porter, Alexandra E., PhD, Carlsten, Chris, MD, Tetley, Teresa D., PhD, Belvisi, Maria G., PhD

“…Background Diesel exhaust particles (DEPs) are a major component of particulate matter in Europe's largest cities, and epidemiologic evidence links exposure…”
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P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke by Eltom, Suffwan, Stevenson, Christopher S, Rastrick, Joseph, Dale, Nicole, Raemdonck, Kristof, Wong, Sissie, Catley, Matthew C, Belvisi, Maria G, Birrell, Mark A

“…Chronic Obstructive Pulmonary Disease (COPD) is a cigarette smoke (CS)-driven inflammatory airway disease with an increasing global prevalence. Currently there…”
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Role of the inflammasome-caspase1/11-IL-1/18 axis in cigarette smoke driven airway inflammation: an insight into the pathogenesis of COPD by Eltom, Suffwan, Belvisi, Maria G, Stevenson, Christopher S, Maher, Sarah A, Dubuis, Eric, Fitzgerald, Kate A, Birrell, Mark A

“…Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory airway disease often associated with cigarette smoke (CS) exposure. The disease is increasing…”
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Role of transient receptor potential and pannexin channels in cigarette smoke-triggered ATP release in the lung by Baxter, Matthew, Eltom, Suffwan, Dekkak, Bilel, Yew-Booth, Liang, Dubuis, Eric D, Maher, Sarah A, Belvisi, Maria G, Birrell, Mark A

“…COPD is an inflammatory disease usually associated with cigarette smoking (CS) with an increasing global prevalence and no effective medication. Extracellular…”
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TRPA1 Agonists Evoke Coughing in Guinea Pig and Human Volunteers by Birrell, Mark A, Belvisi, Maria G, Grace, Megan, Sadofsky, Laura, Faruqi, Shoaib, Hele, David J, Maher, Sarah A, Freund-Michel, Veronique, Morice, Alyn H

“…Cough is the most frequent reason for consultation with a family doctor, or with a general or respiratory physician. Treatment options are limited and one…”
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PI3Kγδ inhibition suppresses key disease features in a rat model of asthma by Pinkerton, James W, Preite, Silvia, Piras, Antonio, Zervas, Dimitrios, Markou, Thomais, Freeman, Mark S, Hofving, Tobias, Ivarsson, Emil, Bonvini, Sara J, Brailsford, Wayne, Yrlid, Linda, Belvisi, Maria G, Birrell, Mark A

“…Two isoforms of Phosphoinositide 3-kinase (PI3K), p110γ and p110δ, are predominantly expressed in leukocytes and represent attractive therapeutic targets for…”
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Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids by Moschos, Sterghios A, Williams, Andrew E, Perry, Mark M, Birrell, Mark A, Belvisi, Maria G, Lindsay, Mark A

“…At present, nothing is known of the role of miRNAs in the immune response in vivo despite the fact that inflammation is thought to underlie multiple acute and…”
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Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect? by Birrell, Mark A., PhD, Bonvini, Sara J., BSc, Dubuis, Eric, PhD, Maher, Sarah A., PhD, Wortley, Michael A., PhD, Grace, Megan S., PhD, Raemdonck, Kristof, PhD, Adcock, John J., PhD, Belvisi, Maria G., PhD

“…Background Recent studies have suggested that the long-acting muscarinic receptor antagonist tiotropium, a drug widely prescribed for its bronchodilator…”
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Pre-clinical studies in cough research: Role of Transient Receptor Potential (TRP) channels by Grace, Megan S, Dubuis, Eric, Birrell, Mark A, Belvisi, Maria G

“…Abstract Cough is a protective reflex and defence mechanism in healthy individuals, which helps clear excessive secretions and foreign material from the lungs…”
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Theophylline inhibits the cough reflex through a novel mechanism of action by Dubuis, Eric, PhD, Wortley, Michael A., BSc, Grace, Megan S., PhD, Maher, Sarah A., PhD, Adcock, John J., PhD, Birrell, Mark A., PhD, Belvisi, Maria G., PhD

“…Background Theophylline has been used in the treatment of asthma and chronic obstructive pulmonary disease for more than 80 years. In addition to…”
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Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages by Birrell, Mark A., Wong, Sissie, Catley, Matthew C., Belvisi, Maria G.

“…Many of the healthcare consequences of cigarette smoking could be due to its ability to compromise the immune system, and in respiratory diseases like chronic…”
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Respiratory infections cause the release of extracellular vesicles: implications in exacerbation of asthma/COPD by Eltom, Suffwan, Dale, Nicole, Raemdonck, Kristof R G, Stevenson, Christopher S, Snelgrove, Robert J, Sacitharan, Pradeep K, Recchi, Chiara, Wavre-Shapton, Silene, McAuley, Daniel F, O'Kane, Cecilia, Belvisi, Maria G, Birrell, Mark A

“…Infection-related exacerbations of respiratory diseases are a major health concern; thus understanding the mechanisms driving them is of paramount importance…”
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