Search Results - "Birrell, H."

Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial by Mackenzie, Isla S, Ford, Ian, Nuki, George, Hallas, Jesper, Hawkey, Christopher J, Webster, John, Ralston, Stuart H, Walters, Matthew, Robertson, Michele, De Caterina, Raffaele, Findlay, Evelyn, Perez-Ruiz, Fernando, McMurray, John J V, MacDonald, Thomas M, Aziz, J., Dobson, G., Doney, A.S.F., Flynn, R.W.V., Furnace, J., Grieve, J.W.K., Guthrie, G., Jamieson, D., Jennings, C.G., Kean, S., Lund, L.C., McConnachie, A., Pigazzani, F., Riches, P.L., Rix Hanson, M., Rogers, A, Rooke, E.D.M., Thomson, J., Warren, M., Wetherall, K., Wilson, R., Hall, C.P., Maseri, A., Bird, H.A., Murray, G., Dear, J.W., Petrie, M., MacDonald, M., Jhund, P.S., Connolly, E., Murphy, D.J., Paul, N., Olsson, A., Koskinen, P.T., Fuat, A., Foster, A., Saywood, W., Barr, R.J., McConnachie, L., Wilson, L.F., Larsen Rasmussen, L., McGinnis, A.R., Birrell, H., Keiller, M., Bremner, I.S., Forbes, G.J., Dumbleton, J.S., Rhodes, J., Waller, T.

“…Febuxostat and allopurinol are urate-lowering therapies used to treat patients with gout. Following concerns about the cardiovascular safety of febuxostat, the…”
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Consistent differences in tissue oxygen levels across 15 insect species reflect a balance between oxygen supply and demand and highlight a hitherto unknown adaptation for extracting sufficient oxygen from water by Birrell, Jackson H., Verberk, Wilco C.E.P., Woods, H. Arthur

“…•We measured tissue PO2 in juvenile and adult insects from 15 species and nine orders.•PO2 varied in juveniles and adults by habitat, activity level, and stage…”
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Invertebrate community response to fire and rodent activity in the Mojave and Great Basin Deserts by Day, Joshua D., Birrell, Jackson H., Terry, Tyson J., Clark, Amy, Allen, Phil, St. Clair, Samuel B.

“…Recent increases in the frequency and size of desert wildfires bring into question the impacts of fire on desert invertebrate communities. Furthermore,…”
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Going with the flow - how a stream insect, Pteronarcys californica, exploits local flows to increase oxygen availability by Birrell, Jackson H, Woods, H Arthur

“…For insects, life in water is challenging because oxygen supply is typically low compared with in air. Oxygen limitation may occur when oxygen levels or water…”
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Insects in high‐elevation streams: Life in extreme environments imperiled by climate change by Birrell, Jackson H., Shah, Alisha A., Hotaling, Scott, Giersch, J. Joseph, Williamson, Craig E., Jacobsen, Dean, Woods, H. Arthur

“…Climate change is altering conditions in high‐elevation streams worldwide, with largely unknown effects on resident communities of aquatic insects. Here, we…”
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Flow increases tolerance of heat and hypoxia of an aquatic insect by Frakes, James I, Birrell, Jackson H, Shah, Alisha A, Woods, H Arthur

“…Recent experiments support the idea that upper thermal limits of aquatic insects arise, at least in part, from a lack of sufficient oxygen: rising temperatures…”
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Warming undermines emergence success in a threatened alpine stonefly: A multi‐trait perspective on vulnerability to climate change by Shah, Alisha A., Hotaling, Scott, Lapsansky, Anthony B., Malison, Rachel L., Birrell, Jackson H., Keeley, Tylor, Giersch, J. Joseph, Tronstad, Lusha M., Woods, H. Arthur

“…Vulnerability to warming is often assessed using short‐term metrics such as the critical thermal maximum (CTMAX), which represents an organism's ability to…”
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Mechanisms underlying thermal breadth differ by species in insects from adjacent but thermally distinct streams – A test of the climate variability hypothesis by Birrell, Jackson H., Frakes, James I., Shah, Alisha A., Woods, H. Arthur

“…The Climate Variability Hypothesis (CVH) predicts that ectotherms from thermally variable climates should have wider thermal tolerances than their counterparts…”
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Performance prediction of Firefinder radar using high fidelity simulation by Lam, Eric P, Birrell, H Walker, Magallon, Julianna

“…Thales Raytheon Systems' PC Simulation (PCS) tool allows a rapid simulated evaluation of Firefinder radar performance from a personal desktop computer…”
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A Probe for the Versatile Analysis and Characterization of N-Linked Oligosaccharides by Charlwood, Joanne, Birrell, Helen, Gribble, Andy, Burdes, Vincent, Tolson, David, Camilleri, Patrick

“…A novel fluorescent probe, 3-(acetylamino)-6-aminoacridine (AA-Ac), has been synthesized and its applicability to the analysis of picomole levels of N-linked…”
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Analysis of Oligosaccharides by Microbore High-Performance Liquid Chromatography by Charlwood, Joanne, Birrell, Helen, Bouvier, Edouard S. P, Langridge, Jim, Camilleri, Patrick

“…A 1-mm microbore hydrophilic interaction column has been used for the separation of 2-aminoacridone (2-AMAC)-derivatized glycan mixtures, released from…”
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Non-thiazolidinedione antihyperglycaemic agents. Part 3: the effects of stereochemistry on the potency of α-methoxy-β-phenylpropanoic acids by Haigh, David, Allen, Graham, Birrell, Helen C., Buckle, Derek R., Cantello, Barrie C.C., Eggleston, Drake S., Haltiwanger, R.Curtis, Holder, Julie C., Lister, Carolyn A., Pinto, Ivan L., Rami, Harshad K., Sime, John T., Smith, Stephen A., Sweeney, John D.

“…Rhizopus delemar lipase catalysed ester hydrolysis of the α-methoxy-β-phenylpropanoate 1 affords the ( R)-(+) and ( S)-(−) isomers in >84% enantiomeric excess…”
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Proteomics in pharmaceutical research and development by Cutler, P, Birrell, H, Haran, M, Man, W, Neville, B, Rosier, S, Skehel, M, White, I

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The effect of phytic acid on the resolution of peptides and proteins in capillary electrophoresis by Okafo, G N, Birrell, H C, Greenaway, M, Haran, M, Camilleri, P

“…Studies are reported on the effect of the sodium salt of phytic acid on the resolution of peptides and proteins. Improved separation in the case of peptides is…”
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An integrated proteomic approach to studying glomerular nephrotoxicity by Cutler, Paul, Bell, David J., Birrell, Helen C., Connelly, John C., Connor, Susan C., Holmes, Elaine, Mitchell, Bob C., Monté, Soraya Y., Neville, Bill A., Pickford, Russell, Polley, Steven, Schneider, Klaus, Skehel, J. Mark

“…A single dose of puromycin aminonucleoside (PAN) given parenterally to rats induces ultrastructural glomerular changes and a nephrotic syndrome similar in many…”
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System performance prediction of Firefinder radar by Lam, Eric P, Walker Birrell, H, Magallon, Julianna

“…Thales Raytheon Systems' PC Simulation (PCS) tool allows a rapid simulated evaluation of Firefinder radar performance from a personal desktop computer…”
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A capillary electrophoresis assay for the fibrinolytic agent, eminase by BIRRELL, H. C, BRIGHTWELL, M. D, CAMILLERI, P

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Randomised double blind controlled study of recurrence of gastric ulcer after treatment for eradication of Helicobacter pylori infection by Axon, A T R, Ó'Moráin, C A, Bardhan, K D, Crowe, J P, Dixon, M F, Beattie, A D, Thompson, R P H, Smith, P M, Hollanders, F D, Baron, J H, Lynch, D A F, Tompkins, D S, Birrell, H, Gillon, K R W

“…Abstract Objective: To determine whether eradication of Helicobacter pylori infection reduces recurrence of benign gastric ulceration. Design: Randomised,…”
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Comparison of the effect of two dose schedules of oral omeprazole with oral ranitidine on gastric aspirate pH and volume in patients undergoing elective surgery by Levack, I D, Bowie, R A, Braid, D P, Asbury, A J, Marshall, R L, Slawson, K B, Birrell, H, Gillon, K R

“…We have compared gastric aspirate pH and volume at induction of anaesthesia in 222 patients who had received either omeprazole or ranitidine before elective…”
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A comparative study of the asparagine‐linked oligosaccharides on siglec‐5, siglec‐7 and siglec‐8, expressed in a CHO cell line, and their contribution to ligand recognition by Freeman, Sylvie, Birrell, Helen C., D'Alessio, Karla, Erickson‐Miller, Connie, Kikly, Kristine, Camilleri, Patrick

“…The siglecs (sialic acid‐binding immunoglobulin‐like lectins) mediate sialic acid‐dependent cellular interactions and may in some cases signal through…”
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