Infection in preterm infants receiving topical emollient oil massage: a systematic review and meta-analysis of randomised control trials

Infection in preterm infants receiving topical emollient oil massage: a systematic review and meta-analysis of randomised control trials

BackgroundPreterm infants are highly susceptible to infections, which significantly contribute to morbidity and mortality. This systematic review and meta-analysis investigated the effectiveness of topical emollient oil application in preventing infections among preterm infants.MethodsA comprehensiv...

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Bibliographic Details
Published in:BMJ paediatrics open Vol. 8; no. 1; p. e002364
Main Authors: Getaneh, Fekadeselassie Belege, Asmare, Aden, Abayneh, Bezabih, Birre, Endalk, Mohammed, Anissa, Muche, Amare, Gedefie, Alemu, Asmamaw, Yibeltal, Mengesha, Zemen, Moges, Natnael, Birhanu, Dires Mihretie, Bitew, Zebenay Workneh, Molla, Asressie
Format: Journal Article
Language:English
Published: England BMJ Publishing Group Ltd 10-07-2024
BMJ Publishing Group LTD
BMJ Publishing Group
Subjects:
Administration, Topical
Collaboration
Emollients - administration & dosage
Emollients - therapeutic use
Epidemiology
Grey literature
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - prevention & control
Infections
Intervention
Massage - methods
Meta-analysis
Neonatology
Newborn babies
Nursing Care
Pediatrics
Premature babies
Premature birth
Randomized Controlled Trials as Topic
Review
Skin care products
Systematic review
Nursing Care
Neonatology
Epidemiology
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Summary:BackgroundPreterm infants are highly susceptible to infections, which significantly contribute to morbidity and mortality. This systematic review and meta-analysis investigated the effectiveness of topical emollient oil application in preventing infections among preterm infants.MethodsA comprehensive search was conducted across multiple electronic databases (PubMed, Cochrane, Scopus, Clinical trials, Epistemonikos, HINARI and Global Index Medicus) and other sources. A total of 2185 articles were identified and screened for eligibility. The quality of included studies was assessed using the Cochrane Risk of Bias Tool for randomised controlled trials. Data analysis was performed using StataCrop MP V.17 software. Heterogeneity among the studies was evaluated using the I2 and Cochrane Q test statistics. Sensitivity and subgroup analyses were conducted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist guided the presentation of the results.ResultsOf 2185 retrieved articles from initial searches, 11 met eligibility criteria and were included in the final analysis. A random effects meta-analysis revealed that infants who received massages with emollient oils had a 21% reduced risk of infection (risk ratio=0.79, 95% CI 0.64 to 0.97, I2=0.00%). Subgroup analyses indicated that preterm babies who received topical emollient oil massages with coconut oil, administered twice a day for more than 2 weeks, had a lower likelihood of acquiring an infection compared with their non-massaged counterparts.ConclusionIt is quite evident from this analysis that topical emollient oil application in preterm neonates is most likely effective in preventing infection. However, further studies, particularly from the African continent, are warranted to support universal recommendations.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-4
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ISSN:2399-9772
2399-9772
DOI:10.1136/bmjpo-2023-002364