Search Results - "Birnie, Matthew"

Dynamics of ACTH and Cortisol Secretion and Implications for Disease by Lightman, Stafford L, Birnie, Matthew T, Conway-Campbell, Becky L

“…Abstract The past decade has seen several critical advances in our understanding of hypothalamic–pituitary–adrenal (HPA) axis regulation. Homeostatic…”
Get full text

Principles of emotional brain circuit maturation by Birnie, Matthew T, Baram, Tallie Z

“…Early-life environmental signals contribute to how the brain handles reward, stress, and fear…”
Get full text

Plasticity of the Reward Circuitry After Early-Life Adversity: Mechanisms and Significance by Birnie, Matthew T., Kooiker, Cassandra L., Short, Annabel K., Bolton, Jessica L., Chen, Yuncai, Baram, Tallie Z.

“…Disrupted operation of the reward circuitry underlies many aspects of affective disorders. Such disruption may manifest as aberrant behavior including risk…”
Get full text

Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice by Birnie, Matthew T., Short, Annabel K., de Carvalho, Gregory B., Taniguchi, Lara, Gunn, Benjamin G., Pham, Aidan L., Itoga, Christy A., Xu, Xiangmin, Chen, Lulu Y., Mahler, Stephen V., Chen, Yuncai, Baram, Tallie Z.

“…Disrupted operations of the reward circuit underlie major emotional disorders, including depression, which commonly arise following early life stress /…”
Get full text

Circadian regulation of hippocampal function is disrupted with corticosteroid treatment by Birnie, Matthew T, Claydon, Matthew D B, Troy, Oliver, Flynn, Benjamin P, Yoshimura, Mitsuhiro, Kershaw, Yvonne M, Zhao, Zidong, Demski-Allen, Rebecca C R, Barker, Gareth R I, Warburton, E Clea, Bortolotto, Zuner A, Lightman, Stafford L, Conway-Campbell, Becky L

“…Disrupted circadian activity is associated with many neuropsychiatric disorders. A major coordinator of circadian biological systems is adrenal glucocorticoid…”
Get full text

Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver by Flynn, Benjamin P, Birnie, Matthew T, Kershaw, Yvonne M, Pauza, Audrys G, Kim, Sohyoung, Baek, Songjoon, Rogers, Mark F, Paterson, Alex R, Stavreva, Diana A, Murphy, David, Hager, Gordon L, Lightman, Stafford L, Conway-Campbell, Becky L

“…Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we…”
Get full text

The Paraventricular Thalamus: A Potential Sensor and Integrator of Emotionally Salient Early-Life Experiences by Kooiker, Cassandra L, Birnie, Matthew T, Baram, Tallie Z

“…Early-life experiences influence a broad spectrum of behaviors throughout the lifespan that contribute to resilience or vulnerability to mental health…”
Get full text

Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanisms by Baram, Tallie Z., Birnie, Matthew T.

“…Adverse early life experiences are strongly associated with reduced cognitive function throughout life. The link is strong in many human studies, but these do…”
Get full text

Enduring disruption of reward and stress circuit activities by early-life adversity in male rats by Levis, Sophia C., Birnie, Matthew T., Bolton, Jessica L., Perrone, Christina R., Montesinos, Johanna S., Baram, Tallie Z., Mahler, Stephen V.

“…In humans, early-life adversity (ELA) such as trauma, poverty, and chaotic environment is linked to increased risk of later-life emotional disorders including…”
Get full text

Functional Connectivity of the Human Paraventricular Thalamic Nucleus: Insights From High Field Functional MRI by Kark, Sarah M, Birnie, Matthew T, Baram, Tallie Z, Yassa, Michael A

“…The paraventricular thalamic nucleus (PVT) is a small but highly connected nucleus of the dorsal midline thalamus. The PVT has garnered recent attention as a…”
Get full text

Identification of a novel GR-ARID1a-P53BP1 protein complex involved in DNA damage repair and cell cycle regulation by Stubbs, Felicity E., Flynn, Benjamin P., Rivers, Caroline A., Birnie, Matthew T., Herman, Andrew, Swinstead, Erin E., Baek, Songjoon, Fang, Hai, Temple, Jillian, Carroll, Jason S., Hager, Gordon L., Lightman, Stafford L., Conway-Campbell, Becky L.

“…ARID1a (BAF250), a component of human SWI/SNF chromatin remodeling complexes, is frequently mutated across numerous cancers, and its loss of function has been…”
Get full text

Time of day influences stress hormone response to ketamine by Birnie, Matthew T., Eapen, Alen V., Kershaw, Yvonne M., Lodge, David, Collingridge, Graham L., Conway‐Campbell, Becky L., Lightman, Stafford L.

“…Over 50% of depressed patients show hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis. Conventional therapy takes weeks to months to improve…”
Get full text

Single-Cell Transcriptional Changes in Hypothalamic Corticotropin-Releasing Factor–Expressing Neurons After Early-Life Adversity Inform Enduring Alterations in Vulnerabilities to Stress by Short, Annabel K., Thai, Christina W., Chen, Yuncai, Kamei, Noriko, Pham, Aidan L., Birnie, Matthew T., Bolton, Jessica L., Mortazavi, Ali, Baram, Tallie Z.

“…Mental health and vulnerabilities to neuropsychiatric disorders involve the interplay of genes and environment, particularly during sensitive developmental…”
Get full text

Genetic Tagging Uncovers a Robust, Selective Activation of the Thalamic Paraventricular Nucleus by Adverse Experiences Early in Life by Kooiker, Cassandra L., Chen, Yuncai, Birnie, Matthew T., Baram, Tallie Z.

“…Early-life adversity (ELA) is associated with increased risk for mood disorders, including depression and substance use disorders. These disorders are…”
Get full text

Developmental Trajectories of Anhedonia in Preclinical Models by Birnie, Matthew T, Levis, Sophia C, Mahler, Stephen V, Baram, Tallie Z

“…This chapter discusses how the complex concept of anhedonia can be operationalized and studied in preclinical models. It provides information about the…”
Get more information

Ultradian glucocorticoid exposure directs gene-dependent and tissue-specific mRNA expression patterns in vivo by George, Charlotte L., Birnie, Matthew T., Flynn, Benjamin P., Kershaw, Yvonne M., Lightman, Stafford L., Conway-Campbell, Becky L.

“…In this paper we report differential decoding of the ultradian corticosterone signal by glucocorticoid target tissues. Pulsatile corticosterone replacement in…”
Get full text

Corrigendum: Functional Connectivity of the Human Paraventricular Thalamic Nucleus: Insights From High Field Functional MRI by Kark, Sarah M, Birnie, Matthew T, Baram, Tallie Z, Yassa, Michael A

“…[This corrects the article DOI: 10.3389/fnint.2021.662293.]…”
Get full text

Genome-Wide Identification of Basic Helix–Loop–Helix and NF-1 Motifs Underlying GR Binding Sites in Male Rat Hippocampus by Pooley, John R., Flynn, Ben P., Grøntved, Lars, Baek, Songjoon, Guertin, Michael J., Kershaw, Yvonne M., Birnie, Matthew T., Pellatt, Annie, Rivers, Caroline A., Schiltz, R. Louis, Hager, Gordon L., Lightman, Stafford L., Conway-Campbell, Becky L.

“…Glucocorticoids regulate hippocampal function in part by modulating gene expression through the glucocorticoid receptor (GR). GR binding is highly cell type…”
Get full text

Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury by Birnie, Matthew, Morrison, Ryan, Camara, Ramatoulie, Strauss, Kenneth I

“…Traumatic brain injury (TBI) induces arachidonic acid (ArA) release from cell membranes. ArA metabolites form a class of over 50 bioactive eicosanoids that can…”
Get full text

Opioid drug seeking after early-life adversity: a role for delta opioid receptors by Levis, Sophia C., Birnie, Matthew T., Xie, Yiyan, Kamei, Noriko, Kulkarni, Puja V., Montesinos, Johanna S., Perrone, Christina R., Cahill, Catherine M., Baram, Tallie Z., Mahler, Stephen V.

“…Opioid use disorder (OUD) is associated with a history of early-life adversity (ELA), an association that is particularly strong in women. In a rodent model,…”
Get full text