Search Results - "Birnbaumer, L"

The TRP Channels, a Remarkably Functional Family by Montell, Craig, Birnbaumer, Lutz, Flockerzi, Veit

“…TRP cation channels display an extraordinary assortment of selectivities and activation mechanisms, some of which represent previously unrecognized modes for…”
Get full text

Membrane depolarization combined with Gq-activated G-protein-coupled receptors induce transient receptor potential channel 1 (TRPC1)- dependent potentiation of catecholamine release by Marom, M, Birnbaumer, L, Atlas, D

“…Abstract Agonists of the Gq/11 -activated G-protein-coupled receptors (GPCRs) combined with strong membrane depolarization (high KCl) induce a synergistic…”
Get full text

A Unified Nomenclature for the Superfamily of TRP Cation Channels by Montell, Craig, Birnbaumer, Lutz, Flockerzi, Veit, Bindels, René J., Bruford, Elspeth A., Caterina, Michael J., Clapham, David E., Harteneck, Christian, Heller, Stefan, Julius, David, Kojima, Itaru, Mori, Yasuo, Penner, Reinhold, Prawitt, Dirk, Scharenberg, Andrew M., Schultz, Günter, Shimizu, Nobuyoshi, Zhu, Michael X.

Get full text

P.19.9 G α i2 signaling is required for skeletal muscle regeneration and for satellite cell differentiation by Minetti, G.C, Feige, J.N, Bombard, F, Birnbaumer, L, Glass, D.J, Fornaro, M

“…We have previously shown that expression of a constitutively active mutant of the á subunit of the heterotrimeric G α i2 protein, G α i2 (Q205L), is sufficient…”
Get full text

Genetic disruption of G proteins, G i2 α or G o α, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium by Boknik, P, Grote‐Wessels, S, Barteska, G, Jiang, M, Müller, FU, Schmitz, W, Neumann, J, Birnbaumer, L

“…Background and purpose:  Classically, stimulation of muscarinic cholinoceptors exerts negative inotropic and chronotropic effects in the atrium of mammalian…”
Get full text

Genetic disruption of G proteins, G(i2)alpha or G(o)alpha, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium by Boknik, P, Grote-Wessels, S, Barteska, G, Jiang, M, Müller, F U, Schmitz, W, Neumann, J, Birnbaumer, L

“…Classically, stimulation of muscarinic cholinoceptors exerts negative inotropic and chronotropic effects in the atrium of mammalian hearts. These effects are…”
Get full text

A comparison of the genes coding for canonical TRP channels and their M, V and P relatives by Birnbaumer, Lutz, Yidirim, Eda, Abramowitz, Joel

“…The mammalian transient receptor potential (TRP) protein gene family consists of a diverse group of cation channels that currently contain at least 26 members…”
Get full text

Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells by Gudermann, T, Birnbaumer, M, Birnbaumer, L

“…The murine receptor for luteinizing hormone (LHR) was cloned and expressed in L cells. This LHR (mature protein of 674 amino acids) is very similar to that of…”
Get full text

TRPC2: molecular biology and functional importance by Yildirim, E, Birnbaumer, L

“…TRPC (canonical transient receptor potential) channels are the closest mammalian homologs of Drosophila TRP and TRP-like channels. TRPCs are rather…”
Get more information

Cloning and expression of a neuronal calcium channel beta subunit by A Castellano, X Wei, L Birnbaumer, E Perez-Reyes

“…Although pharmacological and electrophysiological studies have demonstrated the existence of multiple types of voltage-dependent calcium channels in neuronal…”
Get full text

Cloning and expression of a third calcium channel beta subunit by Castellano, A, Wei, X, Birnbaumer, L, Perez-Reyes, E

“…The skeletal muscle dihydropyridine receptor/Ca2+ channel consists of five distinct subunits (alpha 1, alpha 2 delta, beta 1, and gamma). Homologous alpha 1,…”
Get full text

Citation for the 2000 Distinguished Educator Award of The Endocrine Society to Dr. Stanley Korenman by Birnbaumer, L

Get full text

The IVS6 segment of the L‐type calcium channel is critical for the action of dihydropyridines and phenylalkylamines by Schuster, A., Lacinová, L., Klugbauer, N., Ito, H., Birnbaumer, L., Hofmann, F.

“…The current through the L‐type calcium channel is inhibited and stimulated by distinct dihydropyridines at very low concentrations. The molecular determinants…”
Get full text

The Membrane Topology of Human Transient Receptor Potential 3 as Inferred from Glycosylation-scanning Mutagenesis and Epitope Immunocytochemistry by Vannier, Brigitte, Zhu, Xi, Brown, Darren, Birnbaumer, Lutz

“…Transient receptor potential (Trp) proteins form ion channels implicated in the calcium entry observed after stimulation of the phospholipase C pathway…”
Get full text

Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes by Kirsch, G E, Codina, J, Birnbaumer, L, Brown, A M

“…ATP-sensitive K+ (K+[ATP]) current is thought to be regulated by GTP-binding proteins (G proteins), but the pathways that couple receptor, G protein, and…”
Get full text

Dual signaling potential is common among Gs-coupled receptors and dependent on receptor density by Zhu, X, Gilbert, S, Birnbaumer, M, Birnbaumer, L

“…We studied the relative ability to activate phospholipase C (PLC) of four Gs-coupled receptors expressed in L cells at different densities. Stable cell lines…”
Get more information

Regression of Peyer's patches in Gαi2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis by Öhman, L, Franzén, L, Rudolph, U, Birnbaumer, L, Hörnquist, E Hultgren

“…Background: G protein deficient (Gαi2−/−) mice spontaneously develop an inflammatory bowel disease (IBD) closely resembling ulcerative colitis. Previous…”
Get full text

Trp1‐dependent enhancement of salivary gland fluid secretion: role of store‐operated calcium entry by Singh, Brij B., Zheng, Changyu, Liu, Xibao, Lockwich, Timothy, Liao, Deborah, Zhu, Michael X., Birnbaumer, Lutz, Ambudkar, Indu S.

“…ABSTRACT This study examined the involvement of store‐operated Ca2+ entry in agonist‐stimulation of salivary gland fluid secretion. A recombinant adenovirus…”
Get full text

Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel by Perez-Reyes, E, Castellano, A, Kim, H S, Bertrand, P, Baggstrom, E, Lacerda, A E, Wei, X Y, Birnbaumer, L

“…The skeletal muscle dihydropyridine receptor/Ca2+ channel is composed of five protein components (alpha 1, alpha 2 delta, beta, and gamma). Only two such…”
Get full text

Know thy neighbor: a survey of diseases and complex syndromes that map to chromosomal regions encoding TRP channels by Abramowitz, J, Birnbaumer, L

“…On the basis of their ever-expanding roles, not only in sensory signaling but also in a plethora of other, often Ca(2+)-mediated actions in cell and whole body…”
Get more information