Search Results - "Birnbaum, Kenneth D"
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The potential of single-cell profiling in plants
Published in Genome Biology (05-04-2016)“…Single-cell transcriptomics has been employed in a growing number of animal studies, but the technique has yet to be widely used in plants. Nonetheless, early…”
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Advances and Opportunities in Single-Cell Transcriptomics for Plant Research
Published in Annual review of plant biology (17-06-2021)“…Single-cell approaches are quickly changing our view on biological systems by increasing the spatiotemporal resolution of our analyses to the level of the…”
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Week-long imaging of cell divisions in the Arabidopsis root meristem
Published in Plant methods (25-03-2019)“…Characterizing the behaviors of dynamic systems requires capturing them with high temporal and spatial resolution. Owing to its transparency and genetic…”
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Regulation of Leaf Maturation by Chromatin-Mediated Modulation of Cytokinin Responses
Published in Developmental cell (25-02-2013)“…Plant shoots display indeterminate growth, while their evolutionary decedents, the leaves, are determinate. Determinate leaf growth is conditioned by the…”
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Nitrogen economics of root foraging: Transitive closure of the nitrate–cytokinin relay and distinct systemic signaling for N supply vs. demand
Published in Proceedings of the National Academy of Sciences - PNAS (08-11-2011)“…As sessile organisms, root plasticity enables plants to forage for and acquire nutrients in a fluctuating underground environment. Here, we use genetic and…”
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Quantification of cell identity from single-cell gene expression profiles
Published in Genome Biology (22-01-2015)“…The definition of cell identity is a central problem in biology. While single-cell RNA-seq provides a wealth of information regarding cell states, better…”
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A Case for Distributed Control of Local Stem Cell Behavior in Plants
Published in Developmental cell (26-09-2016)“…The root meristem has a centrally located group of mitotically quiescent cells, to which current models assign a stem cell organizer function. However,…”
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Transcriptome Dynamics of the Stomatal Lineage: Birth, Amplification, and Termination of a Self-Renewing Population
Published in Developmental cell (06-04-2015)“…Developmental transitions can be described in terms of morphology and the roles of individual genes, but also in terms of global transcriptional and epigenetic…”
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Slicing across Kingdoms: Regeneration in Plants and Animals
Published in Cell (22-02-2008)“…Multicellular organisms possessing relatively long life spans are subjected to diverse, constant, and often intense intrinsic and extrinsic challenges to their…”
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10
Cell-specific nitrogen responses mediate developmental plasticity
Published in Proceedings of the National Academy of Sciences - PNAS (15-01-2008)“…The organs of multicellular species consist of cell types that must function together to perform specific tasks. One critical organ function is responding to…”
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Cell-by-cell dissection of phloem development links a maturation gradient to cell specialization
Published in Science (American Association for the Advancement of Science) (24-12-2021)“…In the plant meristem, tissue-wide maturation gradients are coordinated with specialized cell networks to establish various developmental phases required for…”
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Hit-and-run transcriptional control by bZIP1 mediates rapid nutrient signaling in Arabidopsis
Published in Proceedings of the National Academy of Sciences - PNAS (15-07-2014)“…The dynamic nature of gene regulatory networks allows cells to rapidly respond to environmental change. However, the underlying temporal connections are…”
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13
A rapid and sensitive, multiplex, whole mount RNA fluorescence in situ hybridization and immunohistochemistry protocol
Published in Plant methods (22-11-2023)“…Abstract Background In the past few years, there has been an explosion in single-cell transcriptomics datasets, yet in vivo confirmation of these datasets is…”
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A map of cell type‐specific auxin responses
Published in Molecular systems biology (2013)“…In plants, changes in local auxin concentrations can trigger a range of developmental processes as distinct tissues respond differently to the same auxin…”
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Epigenetic memory and cell fate reprogramming in plants
Published in Regeneration (01-02-2017)“…Plants have a high intrinsic capacity to regenerate from adult tissues, with the ability to reprogram adult cell fates. In contrast, epigenetic mechanisms have…”
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Plasticity regulators modulate specific root traits in discrete nitrogen environments
Published in PLoS genetics (01-09-2013)“…Plant development is remarkably plastic but how precisely can the plant customize its form to specific environments? When the plant adjusts its development to…”
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Quantitation of cellular dynamics in growing Arabidopsis roots with light sheet microscopy
Published in PloS one (22-06-2011)“…To understand dynamic developmental processes, living tissues have to be imaged frequently and for extended periods of time. Root development is extensively…”
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Power in Numbers: Single-Cell RNA-Seq Strategies to Dissect Complex Tissues
Published in Annual review of genetics (23-11-2018)“…The growing scale and declining cost of single-cell RNA-sequencing (RNA-seq) now permit a repetition of cell sampling that increases the power to detect rare…”
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Plant Cell Shape: Trafficking Gets Edgy
Published in Developmental cell (22-02-2016)“…Polyhedral-shaped plant cells have faces, corners, and edges that can have different material properties. As Kirchhelle et al. (2016) now show, RAB-A5c reveals…”
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Integration of responses within and across Arabidopsis natural accessions uncovers loci controlling root systems architecture
Published in Proceedings of the National Academy of Sciences - PNAS (10-09-2013)“…Phenotypic plasticity is presumed to be involved in adaptive change toward species diversification. We thus examined how candidate genes underlying natural…”
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