Search Results - "Birktoft, Jens"
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From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal
Published in Nature (London) (03-09-2009)“…We live in a macroscopic three-dimensional (3D) world, but our best description of the structure of matter is at the atomic and molecular scale. Understanding…”
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A device that operates within a self-assembled 3D DNA crystal
Published in Nature chemistry (01-08-2017)“…Structural DNA nanotechnology finds applications in numerous areas, but the construction of objects, 2D and 3D crystalline lattices and devices is prominent…”
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Orienting an Organic Semiconductor into DNA 3D Arrays by Covalent Bonds
Published in Angewandte Chemie International Edition (26-01-2022)“…A quasi‐one‐dimensional organic semiconductor, hepta(p‐phenylene vinylene) (HPV), was incorporated into a DNA tensegrity triangle motif using a covalent…”
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Construction and Structure Determination of a Three-Dimensional DNA Crystal
Published in Journal of the American Chemical Society (10-08-2016)“…Structural DNA nanotechnology combines branched DNA junctions with sticky-ended cohesion to create self-assembling macromolecular architectures. One of the key…”
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Designing Higher Resolution Self-Assembled 3D DNA Crystals via Strand Terminus Modifications
Published in ACS nano (23-07-2019)“…DNA tensegrity triangles self-assemble into rhombohedral three-dimensional crystals via sticky ended cohesion. Crystals containing two-nucleotide (nt) sticky…”
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Self-Assembly of 3D DNA Crystals Containing a Torsionally Stressed Component
Published in Cell chemical biology (16-11-2017)“…There is an increasing appreciation for structural diversity of DNA that is of interest to both DNA nanotechnology and basic biology. Here, we have explored…”
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Structure and biology of tissue factor pathway inhibitor
Published in Thrombosis and haemostasis (01-10-2001)“…Human tissue factor pathway inhibitor (TFPI) is a modular protein comprised of three Kunitz type domains flanked by peptide segments that are less structured…”
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Self-Assembled DNA Crystals: The Impact on Resolution of 5′-Phosphates and the DNA Source
Published in Nano letters (13-02-2013)“…Designed self-assembled DNA crystals consist of rigid DNA motifs that are held together by cohesive sticky-ended interactions. A prominent application of such…”
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Inhibition of Bacterial RNA Polymerase by Streptolydigin: Stabilization of a Straight-Bridge-Helix Active-Center Conformation
Published in Cell (26-08-2005)“…We define the target, mechanism, and structural basis of inhibition of bacterial RNA polymerase (RNAP) by the tetramic acid antibiotic streptolydigin (Stl)…”
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Orienting an Organic Semiconductor into DNA 3D Arrays by Covalent Bonds
Published in Angewandte Chemie (26-01-2022)“…A quasi‐one‐dimensional organic semiconductor, hepta(p‐phenylene vinylene) (HPV), was incorporated into a DNA tensegrity triangle motif using a covalent…”
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Correction to “Construction and Structure Determination of a Three-dimensional DNA Crystal”
Published in Journal of the American Chemical Society (28-09-2016)Get full text
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76 A nanomechanical device that operates in a 3D crystal
Published in Journal of biomolecular structure & dynamics (18-05-2015)Get full text
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Crystal Structure of a Continuous Three-Dimensional DNA Lattice
Published in Chemistry & biology (01-08-2004)“…DNA has proved to be a versatile material for the rational design and assembly of nanometer scale objects. Here we report the crystal structure of a continuous…”
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77 Let's get twisted: the crystal structure of torsionally stressed DNA
Published in Journal of biomolecular structure & dynamics (18-05-2015)Get full text
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The absence of tertiary interactions in a self-assembled DNA crystal structure
Published in Journal of molecular recognition (01-04-2012)“…DNA is a highly effective molecule for controlling nanometer‐scale structure. The convenience of using DNA lies in the programmability of Watson–Crick…”
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Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA
Published in The EMBO journal (01-12-2002)“…AZT (3′‐azido‐3′‐deoxythymidine) resistance involves the enhanced excision of AZTMP from the end of the primer strand by HIV‐1 reverse transcriptase. This…”
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78 Programmable crystal contacts used to improve the resolution of self-assembled 3D DNA crystals
Published in Journal of biomolecular structure & dynamics (18-05-2015)Get full text
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Structure of the Escherichia coli RNA polymerase α subunit C-terminal domain
Published in Acta crystallographica. Section D, Biological crystallography. (01-07-2010)“…The α subunit C‐terminal domain (αCTD) of RNA polymerase (RNAP) is a key element in transcription activation in Escherichia coli, possessing determinants…”
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Structure of the Escherichia coli RNA polymerase a subunit C-terminal domain
Published in Acta crystallographica. Section D, Biological crystallography. (2010)“…The a subunit C-terminal domain (aCTD) of RNA polymerase (RNAP) is a key element in transcription activation in Escherichia coli, possessing determinants…”
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Resolution of Undistorted Symmetric Immobile DNA Junctions by Vaccinia Topoisomerase I
Published in Biochemistry (Easton) (17-02-2004)“…Holliday junctions are intermediates in genetic recombination. They consist of four strands of DNA that flank a branch point. In natural systems, their…”
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