Search Results - "Birkinshaw, Timothy N."

Iodoetherification as a strategy towards sp3-rich scaffolds for drug discovery by Barnes, Lydia, Birkinshaw, Timothy N., Senior, Aaron J., Brügge, Oscar Siles, Lewis, William, Argent, Stephen P., Moody, Christopher J., Nortcliffe, Andrew

“…[Display omitted] Functionalised tetrahydropyran and spirooxepane scaffolds were prepared utilising an iodoetherification strategy and elaborated to…”
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Antagonists of the P2X7 Receptor. From Lead Identification to Drug Development by Guile, Simon D, Alcaraz, Lilian, Birkinshaw, Timothy N, Bowers, Keith C, Ebden, Mark R, Furber, Mark, Stocks, Michael J

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Antagonists of the P2X(7) receptor. From lead identification to drug development by Guile, Simon D, Alcaraz, Lilian, Birkinshaw, Timothy N, Bowers, Keith C, Ebden, Mark R, Furber, Mark, Stocks, Michael J

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From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis by SPRINGTHORPE, Brian, BAILEY, Andrew, HUNT, Simon F, INCE, Francis, INGALL, Anthony H, KIRK, Ian P, LEESON, Paul D, LEFF, Paul, LEWIS, Richard J, MARTIN, Barrie P, MCGINNITY, Dermot F, MORTIMORE, Michael P, BARTON, Patrick, PAINE, Stuart W, PAIRAUDEAU, Garry, PATEL, Anil, RIGBY, Aaron J, RILEY, Robert J, TEOBALD, Barry J, TOMLINSON, Wendy, WEBBORN, Peter J. H, WILLIS, Paul A, BIRKINSHAW, Timothy N, BONNERT, Roger V, BROWN, Roger C, CHAPMAN, David, DIXON, John, GUILE, Simon D, HUMPHRIES, Robert G

“…Starting from adenosine triphosphate (ATP), the identification of a novel series of P2Y(12) receptor antagonists and exploitation of their SAR is described…”
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In silico prediction of acyl glucuronide reactivity by Potter, Tim, Lewis, Richard, Luker, Tim, Bonnert, Roger, Bernstein, Michael A., Birkinshaw, Timothy N., Thom, Stephen, Wenlock, Mark, Paine, Stuart

“…Drugs and drug candidates containing a carboxylic acid moiety, including many widely used non-steroidal anti-inflammatory drugs (NSAIDs) are often metabolized…”
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The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS) by Cheshire, David R., Åberg, Anders, Andersson, Gunilla M.K., Andrews, Glen, Beaton, Haydn G., Birkinshaw, Timothy N., Boughton-Smith, Nigel, Connolly, Stephen, Cook, Tony R., Cooper, Anne, Cooper, Sally L., Cox, David, Dixon, John, Gensmantel, Nigel, Hamley, Peter J., Harrison, Richard, Hartopp, Paul, Käck, Helena, Leeson, Paul D., Luker, Timothy, Mete, Antonio, Millichip, Ian, Nicholls, David J., Pimm, Austen D., St-Gallay, Steve A., Wallace, Alan V.

“…By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective…”
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Discovery of potent CRTh2 (DP 2) receptor antagonists by Birkinshaw, Timothy N., Teague, Simon J., Beech, Claire, Bonnert, Roger V., Hill, Stephen, Patel, Anil, Reakes, Sara, Sanganee, Hitesh, Dougall, Iain G., Phillips, Tim T., Salter, Sylvia, Schmidt, Jerzy, Arrowsmith, Elizabeth C., Carrillo, Juan J., Bell, Fiona M., Paine, Stuart W., Weaver, Richard

“…The discovery and optimisation of potent antagonists of the CRTh2 receptor is described culminating in the synthesis of 12, a novel, potent, selective and…”
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Iodoetherification as a strategy towards sp 3 -rich scaffolds for drug discovery by Barnes, Lydia, Birkinshaw, Timothy N, Senior, Aaron J, Brügge, Oscar Siles, Lewis, William, Argent, Stephen P, Moody, Christopher J, Nortcliffe, Andrew

“…Functionalised tetrahydropyran and spirooxepane scaffolds were prepared utilising an iodoetherification strategy and elaborated to demonstrate their potential…”
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Antagonists of the P2X 7 Receptor. From Lead Identification to Drug Development by Guile, Simon D., Alcaraz, Lilian, Birkinshaw, Timothy N., Bowers, Keith C., Ebden, Mark R., Furber, Mark, Stocks, Michael J.

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From ATP to AZD6140: The discovery of an orally active reversible P2Y 12 receptor antagonist for the prevention of thrombosis by Springthorpe, Brian, Bailey, Andrew, Barton, Patrick, Birkinshaw, Timothy N., Bonnert, Roger V., Brown, Roger C., Chapman, David, Dixon, John, Guile, Simon D., Humphries, Robert G., Hunt, Simon F., Ince, Francis, Ingall, Anthony H., Kirk, Ian P., Leeson, Paul D., Leff, Paul, Lewis, Richard J., Martin, Barrie P., McGinnity, Dermot F., Mortimore, Michael P., Paine, Stuart W., Pairaudeau, Garry, Patel, Anil, Rigby, Aaron J., Riley, Robert J., Teobald, Barry J., Tomlinson, Wendy, Webborn, Peter J.H., Willis, Paul A.

“…Starting with ATP, the identification of novel P2Y 12 receptor antagonists are described. The leading compound, 17 (AZD6140), is currently in a phase III…”
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