Search Results - "Birkett, Christopher R."

Transfer of Scrapie Prion Infectivity by Cell Contact in Culture by Kanu, Nnennaya, Imokawa, Yutaka, Drechsel, David N., Williamson, R. Anthony, Birkett, Christopher R., Bostock, Christopher J., Brockes, Jeremy P.

“…When a cell is infected with scrapie prions, newly synthesized molecules of the prion protein PrPC are expressed at the cell surface and may subsequently be…”
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In vitro cell-free conversion of bacterial recombinant PrP to PrPres as a model for conversion by Kirby, Louise, Birkett, Christopher R, Rudyk, Helene, Gilbert, Ian H, Hope, James

“…1 Institute for Animal Health, Compton Laboratories, Newbury, Berkshire RG20 7NN, UK 2 Welsh School of Pharmacy, Cardiff University, Redwood Building, King…”
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The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper by Wilkins, Simon, Choglay, Ashraf A., Chapple, J. Paul, van der Spuy, Jacqueline, Rhie, Alexandre, Birkett, Christopher R., Cheetham, Michael E.

“…Conformational transitions in the prion protein (PrP) are thought to be central to the pathogenesis of the transmissible spongiform encephalopathies (TSE),…”
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Synthesis of Analogues of Congo Red and Evaluation of Their Anti-Prion Activity by Sellarajah, Shane, Lekishvili, Tamuna, Bowring, Claire, Thompsett, Andrew R, Rudyk, Helene, Birkett, Christopher R, Brown, David R, Gilbert, Ian H

“…No cure as of yet exists for any of the transmissible spongiform encephalopathies. In this paper, we describe the synthesis of analogues of Congo red and…”
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Scrapie strains maintain biological phenotypes on propagation in a cell line in culture by Birkett, Christopher R., Hennion, Ruth M., Bembridge, Dawn A., Clarke, Michael C., Chree, Aileen, Bruce, Moira E., Bostock, Christopher J.

“…Bovine spongiform encephalopathy (BSE) and its human equivalent, variant Creutzfeldt–Jakob disease (vCJD), are caused by the same strain of infectious agent,…”
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Screening Congo Red and its analogues for their ability to prevent the formation of PrP-res in scrapie-infected cells by Rudyk, H, Vasiljevic, S, Hennion, R.M, Birkett, C.R, Hope, J, Gilbert, I.H

“…Transmissible spongiform encephalopathies (TSEs) are incurable, fatal diseases. The dye Congo Red (CR) can cure cells infected with agents of the sheep TSE,…”
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Distribution of cell‐associated prion protein in normal adult blood determined by flow cytometry by Barclay, G. Robin, Hope, James, Birkett, Christopher R., Turner, Marc L.

“…Leucocyte subpopulations from normally healthy individuals were identified by recognized combinations of fluorochrome‐conjugated antibodies to CD markers and…”
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Biochemical typing of scrapie strains by Somerville, Robert A, Chong, Angela, Mulqueen, Orla U, Birkett, Christopher R, Wood, Sophie C. E. R, Hope, James

“…Differences in the molecular heterogeneity of the abnormal isoforms of the prion protein, PrP super(Sc), due to differential glycosylation and partial…”
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Selection of specific phage-display antibodies using libraries derived from chicken immunoglobulin genes by Davies, E.Linda, Smith, Justine S., Birkett, Christopher R., Manser, Jacquie M., Anderson-Dear, Denise V., Young, John R.

“…In chickens, single functional immunoglobulin variable and joining gene segments at each of the heavy and light chain loci undergo V(D)J rearrangement…”
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A monoclonal antibody that enables specific immunohistological detection of prion protein in bovine spongiform encephalopathy cases by Laffling, Alison J., Baird, Alison, Birkett, Christopher R., John, Huw A.

“…The specificity of a monoclonal antibody (mAB) raised against recombinant bovine prion protein (PrP) for the immunohistological detection of PrP accumulation…”
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Use of monoclonal antibodies to analyse the expression of a multi-tubulin family by Birkett, Christopher R., Foster, Kay E., Johnson, Lawrence, Gull, Keith

“…We have used a panel of monoclonal antibodies in a study of the expression of multiple tubulins in Physarum polycephalum. Three anti-β-tubulin monoclonal…”
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Isolation of cDNA clones encoding proteins of complex structures: analysis of the Trypanosoma brucei cytoskeleton by Birkett, C R, Parma, A E, Gerke-Bonet, R, Woodward, R, Gull, K

“…We have adapted a group of well-known procedures in order to devise a simple method that allows the isolation of specific cDNAs encoding proteins located in…”
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Acetylated alpha-tubulin in Physarum: immunological characterization of the isotype and its usage in particular microtubular organelles by Sasse, R, Glyn, M.C.P, Birkett, C.R, Gull, K

“…We have used monoclonal antibodies specific for acetylated and unacetylated α-tubulin to characterize the acetylated α-tubulin isotype of Physarum…”
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Immunological evidence for a Physarum β-tubulin polypeptide possessing an α-tubulin-like carboxyl terminus by Gull, Keith, Wilcox, Marianne, Birkett, Christopher R.

“…A number of well-characterised monoclonal antibodies have been produced which recognise either α- or β-tubulin. One of these antibodies, YL1/2, has been…”
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Recognition of specific Physarumα‐tubulin isotypes by a monoclonal antibody by WALDEN, Paul D., BLINDT, Adrian B., BIRKETT, Christopher R., COX, Robert A., GULL, Keith

“…The monoclonal antibody 6‐11B‐1 recognises specifically the acetylated form of α‐tubulin. The acetylation event occurs on a unique lysine residue, lysine 40…”
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Inhibition of secretion of proteins and triacylglycerol from isolated rat hepatocytes mediated by benzimidazole carbamate antimicrotubule agents by Birkett, C R, Coulson, C, Pogson, C I, Gull, K

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Recognition of specific Physarum α-tubulin isotypes by a monoclonal antibody: sequence heterogeneity around the acetylation site at lysine 40 by WALDEN, P. D, BLINDT, A. B, BIRKETT, C. R, COX, R. A, GULL, K

“…The monoclonal antibody 6-11B-1 recognises specifically the acetylated form of alpha-tubulin. The acetylation event occurs on a unique lysine residue, lysine…”
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