Anti-diabetic effect of betulinic acid on streptozotocin-nicotinamide induced diabetic male mouse model

Anti-diabetic effect of betulinic acid on streptozotocin-nicotinamide induced diabetic male mouse model

Diabetes is a metabolic disease caused by abnormal insulin secretion or action. In the present study, the effects of betulinic acid (BA, a triterpene) are evaluated on glucose, α-amylase and plasma insulin levels, insulin resistance and the histopathology of pancreatic islets in streptozotocin-nicot...

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Bibliographic Details
Published in:Brazilian Journal of Pharmaceutical Sciences Vol. 54; no. 2
Main Authors: Birgani, Golshan Arzani, Ahangarpour, Akram, Khorsandi, Layasadat, Moghaddam, Hadi Fathi
Format: Journal Article
Language:English
Published: Sao Paulo Universidade de Sao Paulo Faculdade de Ciencias 01-01-2018
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Universidade de São Paulo
Subjects:
Acids
Antidiabetics
Betulinic acid
Diabetes
Fasting
Glucose
Hyperglycemia
Insulin resistance
Mouse
PHARMACOLOGY & PHARMACY
Plasma
Rodents
Streptozotocin-nicotinamide
Variance analysis
Iran
United States > US
Streptozotocin-nicotinamide
Diabetes
Mouse
Betulinic acid
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Summary:Diabetes is a metabolic disease caused by abnormal insulin secretion or action. In the present study, the effects of betulinic acid (BA, a triterpene) are evaluated on glucose, α-amylase and plasma insulin levels, insulin resistance and the histopathology of pancreatic islets in streptozotocin-nicotinamide (STZ-NA) diabetic mice. Seventy adult male NMRI mice were randomly divided into seven groups: control, sham, diabetic, diabetic treated with BA (10, 20 and 40 mg/kg) and diabetic treated with metformin (200 mg/kg). Diabetes was induced in mice by intraperitoneal injection of streptozotocin 50 mg/kg after a dose of nicotinamide 120 mg/kg. Two weeks after treatment with BA, blood samples were collected for measuring glucose, α-amylase and insulin levels, and the pancreas was isolated for histopathology evaluation. Diabetes reduced the number and diameter of pancreatic islets, and increased α-amylase and insulin resistance. BA treatment reduced blood glucose, α-amylase and improved insulin sensitivity as well as pancreas histopathology. In addition, BA showed stronger effects on the pancreatic histology and insulin resistance compared to the metformin group.
ISSN:2175-9790
1984-8250
2175-9790
DOI:10.1590/s2175-97902018000217171