Search Results - "Birey, Fikri"

Generation and assembly of human brain region–specific three-dimensional cultures by Sloan, Steven A., Andersen, Jimena, Pașca, Anca M., Birey, Fikri, Pașca, Sergiu P.

“…The ability to generate region-specific three-dimensional (3D) models to study human brain development offers great promise for understanding the nervous…”
Get full text

Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells by Miura, Yuki, Li, Min-Yin, Birey, Fikri, Ikeda, Kazuya, Revah, Omer, Thete, Mayuri Vijay, Park, Jin-Young, Puno, Alyssa, Lee, Samuel H., Porteus, Matthew H., Pașca, Sergiu P.

“…Cortico-striatal projections are critical components of forebrain circuitry that regulate motivated behaviors. To enable the study of the human…”
Get full text

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells by Sloan, Steven A., Darmanis, Spyros, Huber, Nina, Khan, Themasap A., Birey, Fikri, Caneda, Christine, Reimer, Richard, Quake, Stephen R., Barres, Ben A., Paşca, Sergiu P.

“…There is significant need to develop physiologically relevant models for investigating human astrocytes in health and disease. Here, we present an approach for…”
Get full text

Assembly of functionally integrated human forebrain spheroids by Birey, Fikri, Andersen, Jimena, Makinson, Christopher D., Islam, Saiful, Wei, Wu, Huber, Nina, Fan, H. Christina, Metzler, Kimberly R. Cordes, Panagiotakos, Georgia, Thom, Nicholas, O’Rourke, Nancy A., Steinmetz, Lars M., Bernstein, Jonathan A., Hallmayer, Joachim, Huguenard, John R., Paşca, Sergiu P.

“…The development of the nervous system involves a coordinated succession of events including the migration of GABAergic (γ-aminobutyric-acid-releasing) neurons…”
Get full text

Maturation and circuit integration of transplanted human cortical organoids by Revah, Omer, Gore, Felicity, Kelley, Kevin W., Andersen, Jimena, Sakai, Noriaki, Chen, Xiaoyu, Li, Min-Yin, Birey, Fikri, Yang, Xiao, Saw, Nay L., Baker, Samuel W., Amin, Neal D., Kulkarni, Shravanti, Mudipalli, Rachana, Cui, Bianxiao, Nishino, Seiji, Grant, Gerald A., Knowles, Juliet K., Shamloo, Mehrdad, Huguenard, John R., Deisseroth, Karl, Pașca, Sergiu P.

“…Self-organizing neural organoids represent a promising in vitro platform with which to model human development and disease 1 – 5 . However, organoids lack the…”
Get full text

Age-Dependent Netrin-1 Signaling Regulates NG2+ Glial Cell Spatial Homeostasis in Normal Adult Gray Matter by Birey, Fikri, Aguirre, Adan

“…Neuron-glial antigen 2-positive (NG2(+)) glial cells are the most proliferative glia type in the adult CNS, and their tile-like arrangement in adult gray…”
Get full text

Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome by Birey, Fikri, Li, Min-Yin, Gordon, Aaron, Thete, Mayuri V., Valencia, Alfredo M., Revah, Omer, Paşca, Anca M., Geschwind, Daniel H., Paşca, Sergiu P.

“…Defects in interneuron migration can disrupt the assembly of cortical circuits and lead to neuropsychiatric disease. Using forebrain assembloids derived by…”
Get full text

Nondestructive nanostraw intracellular sampling for longitudinal cell monitoring by Cao, Yuhong, Hjort, Martin, Chen, Haodong, Birey, Fikri, Leal-Ortiz, Sergio A., Han, Crystal M., Santiago, Juan G., Paşca, Sergiu P., Wu, Joseph C., Melosh, Nicholas A.

“…Here, we report a method for time-resolved, longitudinal extraction and quantitative measurement of intracellular proteins and mRNA from a variety of cell…”
Get full text

Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like Behaviors through Reduced Secretion of FGF2 by Birey, Fikri, Kloc, Michelle, Chavali, Manideep, Hussein, Israa, Wilson, Michael, Christoffel, Daniel J., Chen, Tony, Frohman, Michael A., Robinson, John K., Russo, Scott J., Maffei, Arianna, Aguirre, Adan

“…NG2-expressing glia (NG2 glia) are a uniformly distributed and mitotically active pool of cells in the central nervous system (CNS). In addition to serving as…”
Get full text

Editorial: Improving in vitro modeling of human brain with future brain organoids by Barral, Serena, Xiang, Yangfei, Birey, Fikri

“…A flurry of protocols has been developed to establish 3D human stem cell-derived models that resemble various human brain regions, providing unique advantages…”
Get full text

50. Roles of Oligodendrocyte Precursor Cells in Brain Physiology by Aguirre, Adan, Birey, Fikri

Get full text

Roles of Oligodendrocyte Precursor Cells in Brain Physiology by Aguirre, Adan, Birey, Fikri

Get full text

Age-Dependent Netrin-1 Signaling Regulates NG2 super(+) Glial Cell Spatial Homeostasis in Normal Adult Gray Matter by Birey, Fikri, Aguirre, Adan

“…Neuron-glial antigen 2-positive (NG2 super(+)) glial cells are the most proliferative glia type in the adult CNS, and their tile-like arrangement in adult gray…”
Get full text

Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals by Liu, Jia, Kim, Yoon Seok, Richardson, Claire E, Tom, Ariane, Ramakrishnan, Charu, Birey, Fikri, Katsumata, Toru, Chen, Shucheng, Wang, Cheng, Wang, Xiao, Joubert, Lydia-Marie, Jiang, Yuanwen, Wang, Huiliang, Fenno, Lief E, Tok, Jeffrey B-H, Pașca, Sergiu P, Shen, Kang, Bao, Zhenan, Deisseroth, Karl

“…The structural and functional complexity of multicellular biological systems, such as the brain, are beyond the reach of human design or assembly capabilities…”
Get full text

ISDN2014_0354: The proliferation, lineage and regenerative potential of heterogeneous NG2+ glia cells in the adult cerebral cortex are regulated by continuous environmental cues by Birey, Fikri, Aguirre, Adan

Get full text

The proliferation, lineage and regenerative potential of heterogeneous NG2+ glia cells in the adult cerebral cortex are regulated by continuous environmental cues by Birey, Fikri, Aguirre, Adan

Get full text

Primate cell fusion disentangles gene regulatory divergence in neurodevelopment by Agoglia, Rachel M., Sun, Danqiong, Birey, Fikri, Yoon, Se-Jin, Miura, Yuki, Sabatini, Karen, Pașca, Sergiu P., Fraser, Hunter B.

“…Among primates, humans display a unique trajectory of development that is responsible for the many traits specific to our species. However, the inaccessibility…”
Get full text

Antisense oligonucleotide therapeutic approach for Timothy syndrome by Chen, Xiaoyu, Birey, Fikri, Li, Min-Yin, Revah, Omer, Levy, Rebecca, Thete, Mayuri Vijay, Reis, Noah, Kaganovsky, Konstantin, Onesto, Massimo, Sakai, Noriaki, Hudacova, Zuzana, Hao, Jin, Meng, Xiangling, Nishino, Seiji, Huguenard, John, Pașca, Sergiu P.

“…Timothy syndrome (TS) is a severe, multisystem disorder characterized by autism, epilepsy, long-QT syndrome and other neuropsychiatric conditions 1 . TS type 1…”
Get full text

Imaging neuronal migration and network activity in human forebrain assembloids by Birey, Fikri, Pașca, Sergiu P.

“…Assembloids generated from human pluripotent stem cells are self-organizing, multicellular in vitro models that recapitulate aspects of cell-cell interactions…”
Get full text

Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like Behaviors through Reduced Secretion of FGF2 by Birey, Fikri, Kloc, Michelle, Chavali, Manideep, Hussein, Israa, Wilson, Michael, Christoffel, Daniel J., Chen, Tony, Frohman, Michael A., Robinson, John K., Russo, Scott J., Maffei, Arianna, Aguirre, Adan

“…(C) Intracellular and cell membrane-bound levels of GLAST from PFC control and iDTR in primary cortical astrocyte cultures at 7DT. Reduced NG2 Density in…”
Get full text