Search Results - "Birdwell, Kelly A"

Cardiovascular disease in the kidney transplant recipient: epidemiology, diagnosis and management strategies by Rangaswami, Janani, Mathew, Roy O, Parasuraman, Raviprasenna, Tantisattamo, Ekamol, Lubetzky, Michelle, Rao, Swati, Yaqub, Muhammad S, Birdwell, Kelly A, Bennett, William, Dalal, Pranav, Kapoor, Rajan, Lerma, Edgar V, Lerman, Mark, McCormick, Nicole, Bangalore, Sripal, McCullough, Peter A, Dadhania, Darshana M

“…Kidney transplantation (KT) is the optimal therapy for end-stage kidney disease (ESKD), resulting in significant improvement in survival as well as quality of…”
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The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients by BIRDWELL, Kelly A, GRADY, Ben, RICHARDSON, Danielle M, ROBINSON, Melanie P, ALP IKIZLER, Talat, RITCHIE, Marylyn D, STEIN, Charles Michael, HAAS, David W, CHOI, Leena, HUA XU, AIHUA BIAN, DENNY, Josh C, MIN JIANG, VRANIC, Gayle, BASFORD, Melissa, COWAN, James D

“…Tacrolimus, an immunosuppressive drug widely prescribed in kidney transplantation, requires therapeutic drug monitoring due to its marked interindividual…”
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Post-Transplant Cardiovascular Disease by Birdwell, Kelly A, Park, Meyeon

“…Cardiovascular disease remains a leading cause of death and morbidity in kidney transplant recipients and a common reason for post-transplant hospitalization…”
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Decreased Antibody Response to Influenza Vaccination in Kidney Transplant Recipients: A Prospective Cohort Study by Birdwell, Kelly A., MD, MSCI, Ikizler, Mine R., MS, Sannella, Edith C., MT, Wang, Li, MS, Byrne, Daniel W., MS, Ikizler, T. Alp, MD, Wright, Peter F., MD

“…Background Antibody response to the inactivated influenza vaccine is not well described in kidney transplant recipients administered newer, but commonly used,…”
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Racial disparities in end-stage renal disease in a high-risk population: the Southern Community Cohort Study by Bock, Fabian, Stewart, Thomas G, Robinson-Cohen, Cassianne, Morse, Jennifer, Kabagambe, Edmond K, Cavanaugh, Kerri L, Birdwell, Kelly A, Hung, Adriana M, Abdel-Kader, Khaled, Siew, Edward D, Akwo, Elvis A, Blot, William J, Ikizler, T Alp, Lipworth, Loren

“…The Southern Community Cohort Study is a prospective study of low socioeconomic status (SES) blacks and whites from the southeastern US, where the burden of…”
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Pulmonary hypertension in patients with chronic kidney disease: invasive hemodynamic etiology and outcomes by O’Leary, Jared M., Assad, Tufik R., Xu, Meng, Birdwell, Kelly A., Farber-Eger, Eric, Wells, Quinn S., Hemnes, Anna R., Brittain, Evan L.

“…Pulmonary hypertension (PH) is common in patients with chronic kidney disease (CKD) and associated with increased mortality but the hemodynamic profiles,…”
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Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity by Daniel, Laura L., Dickson, Alyson L., Zanussi, Jacy T., Miller‐Fleming, Tyne W., Straub, Peter S., Wei, Wei‐Qi, Plummer, W. Dale, Dupont, William D., Liu, Ge, Anandi, Prathima, Reese, Tyler S., Birdwell, Kelly A., Kawai, Vivian K., Hung, Adriana M., Cox, Nancy J., Feng, QiPing, Stein, C. Michael, Chung, Cecilia P.

“…TPMT and NUDT15 variants explain less than 25% of azathioprine‐associated myelotoxicity. There are 25 additional genes in the thiopurine pathway that could…”
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Myoglobin Cast Nephropathy in a Kidney Transplant Patient With Normal Creatine Kinase by Oliveira da Fonseca, Elissa, MD, Jittirat, Arksarapuk, MD, Birdwell, Kelly A., MD, MSCI, Fogo, Agnes B., MD

“…Delayed graft function in kidney transplant recipients is a known complication associated with increased risk of acute rejection and reduced transplant…”
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Waitlist Mortality for Second Kidney Transplants by Fallahzadeh, Mohammad Kazem, Birdwell, Kelly A

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Kidney Transplantation From Hepatitis C Viremic Deceased Donors to Aviremic Recipients in a Real-world Setting by Concepcion, Beatrice P., Binari, Laura A., Schaefer, Heidi, Rega, Scott, Feurer, Irene, Shawar, Saed, Naik, Ruchi, Hickman, Laura, Walker, Jasmine, Kapp, Meghan, Birdwell, Kelly A., Langone, Anthony, Helderman, J. Harold, Ann Sarrell, Bonnie, Kochar, Guneet, Dubray, Bernard, Smith, Kristin, O’Dell, Heather, DeMers, April, Shelton, Princess, Perri, Roman, Shaffer, David, Forbes, Rachel C.

“…Transplantation of hepatitis C viremic (HCV+) deceased donor kidney transplants (DDKT) into aviremic (HCV-) recipients is a strategy to increase organ…”
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Composite CYP3A phenotypes influence tacrolimus dose-adjusted concentration in lung transplant recipients by Liu, Michelle, Shaver, Ciara M., Birdwell, Kelly A., Heeney, Stephanie A., Shaffer, Christian M., Van Driest, Sara L.

“…Interpatient variability in tacrolimus pharmacokinetics is attributed to metabolism by cytochrome P-450 3A4/5 isoenzymes (encoded by CYP3A4 and CYP3A5)…”
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Sensitivity of estimated tacrolimus population pharmacokinetic profile to assumed dose timing and absorption in real‐world data and simulated data by Williams, Michael L., Weeks, Hannah L., Beck, Cole, Birdwell, Kelly A., Van Driest, Sara L., Choi, Leena

“…Aims Use of electronic health record (EHR) data to estimate population pharmacokinetic (PK) profiles necessitates several assumptions. We sought to investigate…”
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Genome‐Wide Approach to Measure Variant‐Based Heritability of Drug Outcome Phenotypes by Muhammad, Ayesha, Aka, Ida T., Birdwell, Kelly A., Gordon, Adam S., Roden, Dan M., Wei, Wei‐Qi, Mosley, Jonathan D., Van Driest, Sara L.

“…Pharmacogenomic studies have successfully identified variants—typically with large effect sizes in drug target and metabolism enzymes—that predict drug outcome…”
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TPMT and NUDT15 Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real‐World Clinical Results by Dickson, Alyson L., Daniel, Laura L., Zanussi, Jacy, Dale Plummer, W., Wei, Wei‐Qi, Liu, Ge, Reese, Tyler, Anandi, Prathima, Birdwell, Kelly A., Kawai, Vivian, Cox, Nancy J., Dupont, William D., Hung, Adriana M., Feng, QiPing, Stein, C. Michael, Chung, Cecilia P.

“…Azathioprine is used frequently to treat several inflammatory conditions. However, treatment is limited by adverse events—in particular, myelotoxicity…”
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Development of a System for Postmarketing Population Pharmacokinetic and Pharmacodynamic Studies Using Real‐World Data From Electronic Health Records by Choi, Leena, Beck, Cole, McNeer, Elizabeth, Weeks, Hannah L., Williams, Michael L., James, Nathan T., Niu, Xinnan, Abou‐Khalil, Bassel W., Birdwell, Kelly A., Roden, Dan M., Stein, C. Michael, Bejan, Cosmin A., Denny, Joshua C., Van Driest, Sara L.

“…Postmarketing population pharmacokinetic (PK) and pharmacodynamic (PD) studies can be useful to capture patient characteristics affecting PK or PD in…”
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Polygenic risk score as a determinant of risk of non‐melanoma skin cancer in a European‐descent renal transplant cohort by Stapleton, Caragh P., Birdwell, Kelly A., McKnight, Amy Jayne, Maxwell, Alexander P., Mark, Patrick B., Sanders, M. Lee, Chapman, Fiona A., van Setten, Jessica, Phelan, Paul J., Kennedy, Claire, Jardine, Alan, Traynor, Jamie P., Keating, Brendan, Conlon, Peter J., Cavalleri, Gianpiero L.

“…Renal transplant recipients have an increased risk of non‐melanoma skin cancer (NMSC) compared to in the general population. Here, we show polygenic risk…”
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The Potential of Pharmacogenomics to Advance Kidney Disease Treatment by Birdwell, Kelly A, Chung, Cecilia P

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Humoral and cellular immune responses to the SARS‐CoV‐2 BNT162b2 vaccine among a cohort of solid organ transplant recipients and healthy controls by Yanis, Ahmad, Haddadin, Zaid, Spieker, Andrew J., Waqfi, Danya, Rankin, Danielle A., Talj, Rana, Thomas, Lora, Birdwell, Kelly A., Ezzell, Lauren, Blair, Marcia, Eason, Joan, Varjabedian, Rebekkah, Warren, Christian M., Nochowicz, Cynthia H., Olson, Eric C., Simmons, Joshua D., Yoder, Sandra, Guy, Madeline, Thomsen, Isaac, Chappell, James D., Kalams, Spyros A., Halasa, Natasha B.

“…Background Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is associated with increased morbidity and mortality in solid organ…”
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Twelve‐month kidney and liver outcomes of kidney transplantation from Hepatitis C Viremic deceased donors to aviremic recipients by Binari, Laura A., Thorne, Peter, Rega, Scott A., Feurer, Irene D., Shawar, Saed, Naik, Ruchi, Birdwell, Kelly A., Helderman, J. Harold, Langone, Anthony, Sarrell, Bonnie Ann, Schaefer, Heidi, DuBray, Bernard John, Eid, Kareem, Hickman, Laura, Shaffer, David, Concepcion, Beatrice P., Forbes, Rachel C.

“…Introduction Utilization of hepatitis C viremic (HCV+) deceased donor kidneys (DDKT) for aviremic recipients increases opportunities for transplantation with…”
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Longitudinal assessment of cardiac morphology and function following kidney transplantation by Kensinger, Clark, Hernandez, Antonio, Bian, Aihua, Fairchild, Meagan, Chen, Guanhua, Lipworth, Loren, Ikizler, T. Alp, Birdwell, Kelly A.

“…Background Abnormal cardiac morphology is a risk factor for cardiovascular complications in kidney transplant patients. A supraphysiologic level of fibroblast…”
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