Search Results - "Bird, Tom G"
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Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease
Published in Nature medicine (01-04-2012)“…Hepatic precursor cells (HPCs) are known to be bipotent and to give rise to both new hepatocytes and cholangiocytes upon acute liver injury. Stuart J. Forbes…”
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Galectin-3 regulates hepatic progenitor cell expansion during liver injury
Published in Gut (01-02-2015)“…Following chronic liver injury or when hepatocyte proliferation is impaired, ductular reactions containing hepatic progenitor cells (HPCs) appear in the…”
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Decompensated liver cirrhosis
Published in Anaesthesia and intensive care medicine (01-04-2015)“…Abstract The incidence of liver disease continues to increase and is now one of the leading causes of death in the United Kingdom. The increasing prevalence of…”
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Donor cytokine genotype influences the development of acute rejection after renal transplantation
Published in Transplantation (15-02-2001)“…Acute allograft rejection remains an important cause of morbidity after kidney transplantation, and has been shown to be a crucial determinant of long-term…”
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Macrophage derived Wnt signalling opposes Notch signalling in a Numb mediated manner to specify HPC fate in chronic liver disease in human and mouse
Published in Nature medicine (04-03-2012)“…During chronic injury, regeneration of the adult liver becomes impaired. In this context bipotent Hepatic Progenitor Cells (HPCs) become activated and can…”
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Unified approach to the analysis of genetic variation in serotonergic pathways
Published in American journal of medical genetics (15-12-1999)“…Serotonin is a key neurotransmitter in the central nervous system, and dysregulation of serotonergic pathways has been implicated in the pathogenesis of many…”
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