Search Results - "Bird, Phillip"

Granzyme B Promotes Cytotoxic Lymphocyte Transmigration via Basement Membrane Remodeling by Prakash, Monica D., Munoz, Marcia A., Jain, Rohit, Tong, Philip L., Koskinen, Aulikki, Regner, Matthias, Kleifeld, Oded, Ho, Bosco, Olson, Matthew, Turner, Stephen J., Mrass, Paulus, Weninger, Wolfgang, Bird, Phillip I.

“…Granzyme B (GzmB) is a protease with a well-characterized intracellular role in targeted destruction of compromised cells by cytotoxic lymphocytes. However,…”
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Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes by Janiszewski, Tomasz, Kołt, Sonia, Kaiserman, Dion, Snipas, Scott J., Li, Shuang, Kulbacka, Julita, Saczko, Jolanta, Bovenschen, Niels, Salvesen, Guy, Drąg, Marcin, Bird, Phillip I., Kasperkiewicz, Paulina

“…Natural killer (NK) cells are key innate immunity effectors that combat viral infections and control several cancer types. For their immune function, human NK…”
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The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1 by Pang, Siew Siew, Bayly-Jones, Charles, Radjainia, Mazdak, Spicer, Bradley A., Law, Ruby H. P., Hodel, Adrian W., Parsons, Edward S., Ekkel, Susan M., Conroy, Paul J., Ramm, Georg, Venugopal, Hariprasad, Bird, Phillip I., Hoogenboom, Bart W., Voskoboinik, Ilia, Gambin, Yann, Sierecki, Emma, Dunstone, Michelle A., Whisstock, James C.

“…Macrophage-expressed gene 1 (MPEG1/Perforin-2) is a perforin-like protein that functions within the phagolysosome to damage engulfed microbes. MPEG1 is thought…”
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Mice heterozygous for the Serpinb6a null mutation show deficits in central auditory function after acoustic trauma by Tan, Justin, Kaiserman, Dion, O’Leary, Stephen J, Bird, Phillip I.

“…Complete deficiency of the serine protease inhibitor gene, SERPINB6, is responsible for autosomal-recessive, nonsyndromic sensorineural hearing loss in humans…”
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RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation by Wilson, Jane A C, Prow, Natalie A, Schroder, Wayne A, Ellis, Jonathan J, Cumming, Helen E, Gearing, Linden J, Poo, Yee Suan, Taylor, Adam, Hertzog, Paul J, Di Giallonardo, Francesca, Hueston, Linda, Le Grand, Roger, Tang, Bing, Le, Thuy T, Gardner, Joy, Mahalingam, Suresh, Roques, Pierre, Bird, Phillip I, Suhrbier, Andreas

“…Chikungunya virus (CHIKV) is an arthritogenic alphavirus causing epidemics of acute and chronic arthritic disease. Herein we describe a comprehensive RNA-Seq…”
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Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe by Kołt, Sonia, Janiszewski, Tomasz, Kaiserman, Dion, Modrzycka, Sylwia, Snipas, Scott J, Salvesen, Guy, Dra̧g, Marcin, Bird, Phillip I, Kasperkiewicz, Paulina

“…Cytotoxic T-lymphocytes (CTLs) and natural killer cells (NKs) kill compromised cells to defend against tumor and viral infections. Both effector cell types use…”
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Increased susceptibility to acoustic trauma in a mouse model of non‐syndromic sensorineural deafness, DFNB91 by Tan, Justin, Kaiserman, Dion, O'Leary, Stephen J., Bird, Phillip I.

“…Inactivating mutations of SERPINB6 in humans result in progressive hearing loss starting in early adulthood (DFNB91). We have previously shown that C57BL/6J…”
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Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation by Santiago, Llipsy, Castro, Marta, Sanz-Pamplona, Rebeca, Garzón, Marcela, Ramirez-Labrada, Ariel, Tapia, Elena, Moreno, Víctor, Layunta, Elena, Gil-Gómez, Gabriel, Garrido, Marta, Peña, Raúl, Lanuza, Pilar M., Comas, Laura, Jaime-Sanchez, Paula, Uranga-Murillo, Iratxe, del Campo, Rosa, Pelegrín, Pablo, Camerer, Eric, Martínez-Lostao, Luis, Muñoz, Guillermo, Uranga, José A., Alcalde, Anabel, Galvez, Eva M., Ferrandez, Angel, Bird, Phillip I., Metkar, Sunil, Arias, Maykel A., Pardo, Julian

“…If not properly regulated, the inflammatory immune response can promote carcinogenesis, as evident in colorectal cancer (CRC). Aiming to gain mechanistic…”
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Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack by Lopez, Jamie A., Susanto, Olivia, Jenkins, Misty R., Lukoyanova, Natalya, Sutton, Vivien R., Law, Ruby H.P., Johnston, Angus, Bird, Catherina H., Bird, Phillip I., Whisstock, James C., Trapani, Joseph A., Saibil, Helen R., Voskoboinik, Ilia

“…Cytotoxic lymphocytes serve a key role in immune homeostasis by eliminating virus-infected and transformed target cells through the perforin-dependent delivery…”
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Are all granzymes cytotoxic in vivo? by Joeckel, Lars T, Bird, Phillip I

“…Abstract Granzymes are serine proteases mainly found in cytotoxic lymphocytes. The most-studied member of this group is granzyme B, which is a potent cytotoxin…”
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Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2 by Kaiserman, Dion, Zhao, Peishen, Rowe, Caitlin Lorraine, Leong, Andrea, Barlow, Nicholas, Joeckel, Lars Thomas, Hitchen, Corinne, Stewart, Sarah Elizabeth, Hollenberg, Morley D, Bunnett, Nigel, Suhrbier, Andreas, Bird, Phillip Ian

“…Granzyme K (GzmK) is a tryptic member of the granzyme family of chymotrypsin-like serine proteases produced by cells of the immune system. Previous studies…”
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The structural basis for membrane binding and pore formation by lymphocyte perforin by Trapani, Joseph A, Saibil, Helen R, Whisstock, James C, Law, Ruby H. P, Lukoyanova, Natalya, Voskoboinik, Ilia, Caradoc-Davies, Tom T, Baran, Katherine, Dunstone, Michelle A, D'Angelo, Michael E, Orlova, Elena V, Coulibaly, Fasséli, Verschoor, Sandra, Browne, Kylie A, Ciccone, Annette, Kuiper, Michael J, Bird, Phillip I

“…Natural killer cells and cytotoxic T lymphocytes accomplish the critically important function of killing virus-infected and neoplastic cells. They do this by…”
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Manipulation of Proteostasis Networks in Transgenic ZAAT Zebrafish via CRISPR-Cas9 Gene Editing by Fung, Connie, Miles, Lee B, Bryson-Richardson, Robert J, Bird, Phillip I

“…The CRISPR-Cas9 genome editing system is used to induce mutations in genes of interest resulting in the loss of functional protein. A transgenic zebrafish…”
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Expression of the Z Variant of α1-Antitrypsin Suppresses Hepatic Cholesterol Biosynthesis in Transgenic Zebrafish by Fung, Connie, Wilding, Brendan, Schittenhelm, Ralf B, Bryson-Richardson, Robert J, Bird, Phillip I

“…Individuals homozygous for the Pi*Z allele of SERPINA1 (ZAAT) are susceptible to lung disease due to insufficient α1-antitrypsin secretion into the circulation…”
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Granzyme K Expressed by Classically Activated Macrophages Contributes to Inflammation and Impaired Remodeling by Turner, Christopher T., Zeglinski, Matthew R., Richardson, Katlyn C., Zhao, Hongyan, Shen, Yue, Papp, Anthony, Bird, Phillip I., Granville, David J.

“…Granzyme K (GzmK), traditionally described as a pro-apoptotic, granule-secreted serine protease, has been proposed to promote inflammation. Found at low levels…”
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Neurodevelopmental MACPFs: The vertebrate astrotactins and BRINPs by Berkowicz, Susan R., Giousoh, Aminah, Bird, Phillip I.

“…Astrotactins (ASTNs) and Bone morphogenetic protein/retinoic acid inducible neural-specific proteins (BRINPs) are two groups of Membrane Attack…”
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Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation by Ebrahimnezhaddarzi, Salimeh, Bird, Catherina H, Allison, Cody C, Tuipulotu, Daniel E, Kostoulias, Xenia, Macri, Christophe, Stutz, Michael D, Abraham, Gilu, Kaiserman, Dion, Pang, Siew Siew, Man, Si Ming, Mintern, Justine D, Naderer, Thomas, Peleg, Anton Y, Pellegrini, Marc, Whisstock, James C, Bird, Phillip I

“…To control infections phagocytes can directly kill invading microbes. Macrophage‐expressed gene 1 (Mpeg1), a pore‐forming protein sometimes known as…”
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Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies by Rawle, Daniel J, Le, Thuy T, Dumenil, Troy, Bishop, Cameron, Yan, Kexin, Nakayama, Eri, Bird, Phillip I, Suhrbier, Andreas

“…Granzyme A (GZMA) is a serine protease secreted by cytotoxic lymphocytes, with mouse studies having informed our understanding of GZMA's physiological…”
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Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis by Garzón-Tituaña, Marcela, Sierra-Monzón, José L, Comas, Laura, Santiago, Llipsy, Khaliulina-Ushakova, Tatiana, Uranga-Murillo, Iratxe, Ramirez-Labrada, Ariel, Tapia, Elena, Morte-Romea, Elena, Algarate, Sonia, Couty, Ludovic, Camerer, Eric, Bird, Phillip I, Seral, Cristina, Luque, Pilar, Paño-Pardo, José R, Galvez, Eva M, Pardo, Julián, Arias, Maykel

“…Peritonitis is one of the most common causes of sepsis, a serious syndrome characterized by a dysregulated systemic inflammatory response. Recent evidence…”
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SerpinB1 controls encephalitogenic T helper cells in neuroinflammation by Hou, Lifei, Rao, Deepak A., Yuki, Koichi, Cooley, Jessica, Henderson, Lauren A., Jonsson, A. Helena, Kaiserman, Dion, Gorman, Mark P., Nigrovic, Peter A., Bird, Phillip I., Becher, Burkhard, Remold-O’Donnell, Eileen

“…SerpinB1, a protease inhibitor and neutrophil survival factor, was recently linked with IL-17–expressing T cells. Here, we show that serpinB1 (Sb1) is…”
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