Search Results - "Bird, Catherina"

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack by Lopez, Jamie A., Susanto, Olivia, Jenkins, Misty R., Lukoyanova, Natalya, Sutton, Vivien R., Law, Ruby H.P., Johnston, Angus, Bird, Catherina H., Bird, Phillip I., Whisstock, James C., Trapani, Joseph A., Saibil, Helen R., Voskoboinik, Ilia

“…Cytotoxic lymphocytes serve a key role in immune homeostasis by eliminating virus-infected and transformed target cells through the perforin-dependent delivery…”
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Granzyme K‐deficient mice show no evidence of impaired antiviral immunity by Joeckel, Lars T, Allison, Cody C, Pellegrini, Marc, Bird, Catherina H, Bird, Phillip I

“…The biological role of granzyme K, a serine protease of cytotoxic T lymphocytes (CTL), is controversial. It has been reported to induce perforin‐mediated cell…”
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major human and mouse granzymes are structurally and functionally divergent by Kaiserman, Dion, Bird, Catherina H, Sun, Jiuru, Matthews, Antony, Ung, Kheng, Whisstock, James C, Thompson, Philip E, Trapani, Joseph A, Bird, Phillip I

“…Approximately 2% of mammalian genes encode proteases. Comparative genomics reveals that those involved in immunity and reproduction show the most interspecies…”
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Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation by Ebrahimnezhaddarzi, Salimeh, Bird, Catherina H, Allison, Cody C, Tuipulotu, Daniel E, Kostoulias, Xenia, Macri, Christophe, Stutz, Michael D, Abraham, Gilu, Kaiserman, Dion, Pang, Siew Siew, Man, Si Ming, Mintern, Justine D, Naderer, Thomas, Peleg, Anton Y, Pellegrini, Marc, Whisstock, James C, Bird, Phillip I

“…To control infections phagocytes can directly kill invading microbes. Macrophage‐expressed gene 1 (Mpeg1), a pore‐forming protein sometimes known as…”
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Extracellular Matrix Remodeling by Human Granzyme B via Cleavage of Vitronectin, Fibronectin, and Laminin by Buzza, Marguerite S., Zamurs, Laura, Sun, Jiuru, Bird, Catherina H., Smith, A. Ian, Trapani, Joseph A., Froelich, Christopher J., Nice, Edouard C., Bird, Phillip I.

“…Human granzyme B (GrB) released from cytotoxic lymphocytes plays a key role in the induction of target cell apoptosis when internalized in the presence of…”
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A pro‐survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection by Mangan, Matthew S, Melo‐Silva, Carolina R, Luu, Jennii, Bird, Catherina H, Koskinen, Aulikki, Rizzitelli, Alexandra, Prakash, Monica, Scarff, Katrina L, Müllbacher, Arno, Regner, Matthias, Bird, Phillip I

“…Intracellular serpins are proposed to inactivate proteases released from lysosome‐related organelles into the host cell interior, preventing cell death…”
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A Novel Serpin Regulatory Mechanism: SerpinB9 IS REVERSIBLY INHIBITED BY VICINAL DISULFIDE BOND FORMATION IN THE REACTIVE CENTER LOOP by Mangan, Matthew S J, Bird, Catherina H, Kaiserman, Dion, Matthews, Anthony Y, Hitchen, Corinne, Steer, David L, Thompson, Philip E, Bird, Phillip I

“…The intracellular protease inhibitor Sb9 (SerpinB9) is a regulator of the cytotoxic lymphocyte protease GzmB (granzyme B). Although GzmB is primarily involved…”
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Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement by Prakash, Monica D, Bird, Catherina H, Bird, Phillip I

“…Granzyme B (GrB) plays a well‐established intracellular role in cytotoxic lymphocyte (CL)‐mediated killing of abnormal cells; however, emerging evidence…”
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Maspin is not required for embryonic development or tumour suppression by Teoh, Sonia S. Y., Vieusseux, Jessica, Prakash, Monica, Berkowicz, Susan, Luu, Jennii, Bird, Catherina H., Law, Ruby H. P., Rosado, Carlos, Price, John T., Whisstock, James C., Bird, Phillip I.

“…Maspin (SERPINB5) is accepted as an important tumour suppressor lost in many cancers. Consistent with a critical role in development or differentiation maspin…”
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Analysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding by Stewart, Sarah E., Bird, Catherina H., Tabor, Rico F., D'Angelo, Michael E., Piantavigna, Stefania, Whisstock, James C., Trapani, Joseph A., Martin, Lisandra L., Bird, Phillip I.

“…Perforin is an essential component in the cytotoxic lymphocyte-mediated cell death pathway. The traditional view holds that perforin monomers assemble into…”
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The Intracellular Granzyme B Inhibitor, Proteinase Inhibitor 9, Is Up-Regulated During Accessory Cell Maturation and Effector Cell Degranulation, and Its Overexpression Enhances CTL Potency by Hirst, Claire E, Buzza, Marguerite S, Bird, Catherina H, Warren, Hilary S, Cameron, Paul U, Zhang, Manling, Ashton-Rickardt, Philip G, Bird, Phillip I

“…Granzyme B (grB) is a serine proteinase released by cytotoxic lymphocytes (CLs) to kill abnormal cells. GrB-mediated apoptotic pathways are conserved in…”
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Cationic Sites on Granzyme B Contribute to Cytotoxicity by Promoting Its Uptake into Target Cells by Bird, Catherina H., Sun, Jiuru, Ung, Kheng, Karambalis, Diana, Whisstock, James C., Trapani, Joseph A., Bird, Phillip I.

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Use of granzyme B-based fluorescent protein reporters to monitor granzyme distribution and granule integrity in live cells by Bird, Catherina H, Rizzitelli, Alexandra, Harper, Ian, Prescott, Mark, Bird, Phillip I

“…Reporter proteins comprising granzyme B (GrB) fused to eGFP, ecliptic pHluorin or mCherry, were generated and used to study granule (lysosome) distribution and…”
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Serpinb9 (Spi6)‐deficient mice are impaired in dendritic cell‐mediated antigen cross‐presentation by Rizzitelli, Alexandra, Meuter, Simone, Vega Ramos, Javier, Bird, Catherina H, Mintern, Justine D, Mangan, Matthew SJ, Villadangos, Jose, Bird, Phillip I

“…Serpinb9 (Sb9, also called Spi6) is an intracellular inhibitor of granzyme B (GrB) that protects activated cytotoxic lymphocytes from apoptosis. We show here…”
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Common Fold Mediates Vertebrate Defense and Bacterial Attack by Rosado, Carlos J, Buckle, Ashley M, Law, Ruby H.P, Butcher, Rebecca E, Kan, Wan-Ting, Bird, Catherina H, Ung, Kheng, Browne, Kylie A, Baran, Katherine, Bashtannyk-Puhalovich, Tanya A, Faux, Noel G, Wong, Wilson, Porter, Corrine J, Pike, Robert N, Ellisdon, Andrew M, Pearce, Mary C, Bottomley, Stephen P, Emsley, Jonas, Smith, A. Ian, Rossjohn, Jamie, Hartland, Elizabeth L, Voskoboinik, Ilia, Trapani, Joseph A, Bird, Phillip I, Dunstone, Michelle A, Whisstock, James C

“…Proteins containing membrane attack complex/perforin (MACPF) domains play important roles in vertebrate immunity, embryonic development, and neural-cell…”
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Granzyme B Encoded by the Commonly Occurring Human RAH Allele Retains Pro-apoptotic Activity by Sun, Jiuru, Bird, Catherina H., Thia, Kevin Y., Matthews, Antony Y., Trapani, Joseph A., Bird, Phillip I.

“…A key function of human granzyme B (GrB) is to induce apoptosis of target cells in conjunction with perforin. The RAH allele is the first documented variant of…”
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Targeted Disruption of SPI3/Serpinb6 Does Not Result in Developmental or Growth Defects, Leukocyte Dysfunction, or Susceptibility to Stroke by Scarff, Katrina L., Ung, Kheng S., Nandurkar, Harshal, Crack, Peter J., Bird, Catherina H., Bird, Phillip I.

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Selective Regulation of Apoptosis: the Cytotoxic Lymphocyte Serpin Proteinase Inhibitor 9 Protects against Granzyme B-Mediated Apoptosis without Perturbing the Fas Cell Death Pathway by Bird, Catherina H., Sutton, Vivien R., Sun, Jiuru, Hirst, Claire E., Novak, Andrea, Kumar, Sharad, Trapani, Joseph A., Bird, Phillip I.

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A Cytosolic Granzyme B Inhibitor Related to the Viral Apoptotic Regulator Cytokine Response Modifier A Is Present in Cytotoxic Lymphocytes by Sun, Jiuru, Bird, Catherina H., Sutton, Vivien, McDonald, Lisa, Coughlin, Paul B., De Jong, Tanya A., Trapani, Joseph A., Bird, Phillip I.

“…Using a polymerase chain reaction strategy we identified a serine proteinase inhibitor (serpin) in human bone marrow that is related to the cellular serpin…”
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Nucleocytoplasmic Distribution of the Ovalbumin Serpin PI-9 Requires a Nonconventional Nuclear Import Pathway and the Export Factor Crm1 by Bird, Catherina H., Blink, Elizabeth J., Hirst, Claire E., Buzza, Marguerite S., Steele, Pauline M., Sun, Jiuru, Jans, David A., Bird, Phillip I.

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