Search Results - "Birch, N. P."

RNA interference in the light brown apple moth, Epiphyas postvittana (Walker) induced by double-stranded RNA feeding by Turner, C.T, Davy, M.W, MacDiarmid, R.M, Plummer, K.M, Birch, N.P, Newcomb, R.D

“…RNA interference (RNAi) or gene silencing is typically induced in insects by the injection of double-stranded RNAs (dsRNAs), short interfering RNAs, or through…”
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Stress responses to short-term intensified and reduced training in competitive weightlifters by Storey, A. G., Birch, N. P., Fan, V., Smith, H. K.

“…We sought to identify and evaluate the tolerance to, and consequences of, short‐term variations in training load in competitive weightlifters. Seven…”
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Immunohistochemical localisation of the creatine transporter in the rat brain by Mak, C.S.W, Waldvogel, H.J, Dodd, J.R, Gilbert, R.T, Lowe, M.T.J, Birch, N.P, Faull, R.L.M, Christie, D.L

“…Abstract Creatine (Cr) is required to maintain ATP levels in the brain. The transport of Cr across the blood–brain barrier and into neurones requires a…”
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Purification and characterization of the candidate prohormone-processing enzyme SPC3 produced in a mouse L cell line by RUFAUT, N. W, BRENNAN, S. O, HAKES, D. J, DIXON, J. E, BIRCH, N. P

“…SPC3 is a member of a growing family of mammalian subtilisin-like serine proteases which play a probable role in proprotein maturation. In this study we have…”
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Differential Cleavage of Provasopressin by the Major Molecular Forms of SPC3 by Coates, Leigh C., Birch, Nigel P.

“…: We have investigated the roles of full‐length and carboxyl‐terminus‐truncated forms of the subtilisin‐like prohormone convertase SPC3 in the processing of…”
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Pro-thyrotropin-releasing hormone processing by recombinant PC1 by Nillni, E A, Friedman, T C, Todd, R B, Birch, N P, Loh, Y P, Jackson, I M

“…Pro-thyrotropin-releasing hormone (proTRH) is the precursor to thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2), the hypothalamic releasing factor that…”
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Posttranslational Maturation of the Prohormone Convertase SPC3 In Vitro by Coates, Leigh C., Birch, Nigel P.

“…: The subtilisin‐like prohormone convertase SPC3 is likely to play a role in the biosynthesis of a variety of biologically active peptides. SPC3 undergoes a…”
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Comparison of the molecular forms of the Kex2/subtilisin-like serine proteases SPC2, SPC3, and furin in neuroendocrine secretory vesicles reveals differences in carboxyl-terminus truncation and membrane association by Hill, R M, Ledgerwood, E C, Brennan, S O, Pu, L P, Loh, Y P, Christie, D L, Birch, N P

“…The molecular forms and membrane association of SPC2, SPC3, and furin were investigated in neuroendocrine secretory vesicles from the anterior, intermediate,…”
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Characterization of the molecular forms of proenkephalin in bovine adrenal medulla and rat adrenal, brain, and spinal cord with a site-directed antiserum by Birch, N P, Christie, D L

“…An antiserum was generated against a synthetic peptide corresponding to amino acids 95-117 of bovine proenkephalin, and a sensitive radioimmunoassay was…”
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Neuroserpin regulates neurite outgrowth in nerve growth factor‐treated PC12 cells by Parmar, Parmjeet K., Coates, Leigh C., Pearson, John F., Hill, Rena M., Birch, Nigel P.

“…Neuroserpin is a serine protease inhibitor widely expressed in the developing and adult nervous systems and implicated in the regulation of proteases involved…”
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Cloning, sequence and expression of rat cathepsin D by BIRCH, N. P, PENG LOH, Y

“…Cathepsin D is a member of the family of aspartic proteases and is thought to play a role in the lysosomal-mediated degradation of proteins. We have isolated…”
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Distribution and regulation of the candidate prohormone processing enzymes SPC2 and SPC3 in adult rat brain by Birch, N P, Hakes, D J, Dixon, J E, Mezey, E

“…A number of candidate mammalian prohormone processing enzymes related to the yeast Kex2 endoprotease have been cloned and demonstrated to cleave several…”
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An investigation of the molecular properties and stability of intermediates of proenkephalin in isolated bovine adrenal medullary chromaffin granules by Birch, N.P., Davies, A.D., Christie, D.L.

“…An antiserum to a synthetic peptide corresponding to residues 95-117 of bovine proenkephalin recognizes all the major intermediates of this prohormone in…”
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Homology cloning of aspartic proteases from an endocrine cell line using the polymerase chain reaction by Birch, N P, Loh, Y P

“…Oligonucleotides directed towards the active site regions of aspartic proteases were used as primers for the polymerase chain reaction to identify a unique…”
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Immunoreactive insulin from mouse brain cells in culture and whole rat brain by Birch, N P, Christie, D L, Renwick, A G

“…Foetal mouse brain cells were cultured as described previously [Sotelo, Gibbs, Gajdusek, Toh & Wurth (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 653-657] without…”
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Neuroserpin is expressed in the pituitary and adrenal glands and induces the extension of neurite-like processes in AtT-20 cells by Hill, R M, Parmar, P K, Coates, L C, Mezey, E, Pearson, J F, Birch, N P

“…Two cDNAs encoding the serine protease inhibitor (serpin) neuroserpin were cloned from a rat pituitary cDNA library (rNS-1, 2922 bp; rNS-2, 1599 bp). In situ…”
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Expression, Purification, and Functional Characterization of the Serine Protease Inhibitor Neuroserpin Expressed in Drosophila S2 Cells by Hill, Rena M., Brennan, Stephen O., Birch, Nigel P.

“…Neuroserpin (NS) is a serine protease inhibitor (or serpin) that is widely expressed in the developing and adult nervous systems. It has been implicated in the…”
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Pro-opiomelanocortin and pro-vasopressin converting enzyme in pituitary secretory vesicles by Loh, Y P, Birch, N P, Castro, M G

“…Peptide hormones are synthesized from larger precursors by cleavages at paired basic residues. We have isolated a pro-hormone converting enzyme from bovine…”
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Proinsulin-like material in mouse foetal brain cell cultures by Birch, Nigel P., Christie, David L., Renwick, Alistair G.C.

“…Two main forms of immunoreactive insulin have been identified in cultures of foetal mouse brain using HPLC and gel filtration. The major component which…”
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Prohormone Convertase 1 (PC1) When Expressed with Pro Cholecystokinin (Pro CCK) in L Cells Performs Three Endoproteolytic Cleavages Which Are Observed in Rat Brain and in CCK-Expressing Endocrine Cells in Culture, Including the Production of Glycine and Arginine Extended CCK8 by Wang, Wenge, Birch, Nigel P., Beinfeld, Margery C.

“…Pro CCK was expressed in an L cell line engineered to express PC1 and the products secreted into the media were characterized by a combination of RIA, gel…”
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