Search Results - "Bioorganic chemistry"

Cisplatin: The first metal based anticancer drug by Ghosh, Sumit

“…[Display omitted] •History of cisplatin motivates researcher about explanation of negative observation.•Knowledge of synthesis and purification of cisplatin…”
Get full text

Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives by Kumari, Archana, Singh, Rajesh K.

“…[Display omitted] •Indole heterocyclic molecules have huge significance in the field of medicinal chemistry.•The present review focus on synthetic medicinal…”
Get full text

Recent studies of nitrogen containing heterocyclic compounds as novel antiviral agents: A review by Mermer, Arif, Keles, Turgut, Sirin, Yakup

“…[Display omitted] •Different targets have been indicated for antiviral N-heterocyclic compounds.•Investigation of structure-activity relationship (SAR).•5- or…”
Get full text

A review on progression of epidermal growth factor receptor (EGFR) inhibitors as an efficient approach in cancer targeted therapy by Ayati, Adileh, Moghimi, Setareh, Salarinejad, Somayeh, Safavi, Maliheh, Pouramiri, Behjat, Foroumadi, Alireza

“…[Display omitted] The identification of molecular agents inhibiting specific functions in cancer cells progression is considered as one of the most successful…”
Get full text

Medicinal attributes of 1,2,3-triazoles: Current developments by Dheer, Divya, Singh, Virender, Shankar, Ravi

“…[Display omitted] 1,2,3-Triazoles are important five-membered heterocyclic scaffold due to their extensive biological activities. This framework can be readily…”
Get full text

History of the development of antifungal azoles: A review on structures, SAR, and mechanism of action by Shafiei, Mohammad, Peyton, Lee, Hashemzadeh, Mehrnoosh, Foroumadi, Alireza

“…[Display omitted] With the increasing risk of invasive and life threating fungal infections, there is now a great concern regarding the lower discovery rate of…”
Get full text

Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line by Bennani, Fatima Ezzahra, Doudach, Latifa, Cherrah, Yahia, Ramli, Youssef, Karrouchi, Khalid, Ansar, M'hammed, Faouzi, My El Abbes

“…[Display omitted] Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C3H3N2H.The presence of this nucleus in…”
Get full text

Recent advancements of coumarin-based anticancer agents: An up-to-date review by Al-Warhi, Tarfah, Sabt, Ahmed, Elkaeed, Eslam B., Eldehna, Wagdy M.

“…[Display omitted] •The rate of cancer-related mortality is at alarming level globally.•Coumarin as a privileged scaffold is endowed with outstanding anticancer…”
Get full text

Quinolines, a perpetual, multipurpose scaffold in medicinal chemistry by Yadav, Pratibha, Shah, Kamal

“…[Display omitted] Quinoline is a versatile pharmacophore, a privileged scaffold and an outstanding fused heterocyclic compound with a wide range of…”
Get full text

Bovine Serum Albumin (BSA) coated iron oxide magnetic nanoparticles as biocompatible carriers for curcumin-anticancer drug by Nosrati, Hamed, Sefidi, Naser, Sharafi, Ali, Danafar, Hossein, Kheiri Manjili, Hamidreza

“…[Display omitted] •The F@BSA NPs were prepared through desolvation and chemical coprecipitation process.•The F@BSA@CUR NPs were spherical in shape with an…”
Get full text

Thiazolidinediones as antidiabetic agents: A critical review by Nanjan, M.J., Mohammed, Manal, Prashantha Kumar, B.R., Chandrasekar, M.J.N.

“…[Display omitted] •Thiazolidinediones (TZDs) or glitazones are an important class of drugs used in type 2 diabetes mellitus (T2DM).•TZDs are known to act by…”
Get full text

Chalcone derivatives and their antibacterial activities: Current development by Xu, Man, Wu, Piye, Shen, Fan, Ji, Jiayou, Rakesh, K.P.

“…[Display omitted] •Chalcone and its derivatives as showed potent antibacterial agents.•Describe the brief SAR of potent compounds.•This review containing the…”
Get full text

Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors by Turkan, Fikret, Cetin, Adnan, Taslimi, Parham, Karaman, Muhammet, Gulçin, İlhami

“…[Display omitted] •A serie of novel pyrazole compounds (1–8 and 9a, b) was synthesised.•These precursors have been characterized by 1H and 13C NMR and FTIR…”
Get full text

Morpholine as ubiquitous pharmacophore in medicinal chemistry: Deep insight into the structure-activity relationship (SAR) by Kumari, Archana, Singh, Rajesh K.

“…[Display omitted] •Morpholine is a versatile nucleus as it involved in wide range of pharmacological activities.•The present review covers synthetic medicinal…”
Get full text

Computational drug discovery and repurposing for the treatment of COVID-19: A systematic review by Mohamed, Kawthar, Yazdanpanah, Niloufar, Saghazadeh, Amene, Rezaei, Nima

“…[Display omitted] Since the beginning of the novel coronavirus (SARS-CoV-2) disease outbreak, there has been an increasing interest in finding a potential…”
Get full text

The role of long noncoding RNA in major human disease by Zhang, Xiaoli, Hong, Ruiyun, Chen, Weiqiang, Xu, Minwen, Wang, Liefeng

“…Long noncoding RNAs (lncRNAs) are RNAs whose transcripts are longer than 200nt in length and lack the ability to encode proteins due to lack of specific open…”
Get full text

Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4(3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis inducers by Mahdy, Hazem A., Ibrahim, Mohammed K., Metwaly, Ahmed M., Belal, Amany, Mehany, Ahmed B.M., El-Gamal, Kamal M.A., El-Sharkawy, Abdou, Elhendawy, Mostafa A., Radwan, Mohamed M., Elsohly, Mahmoud A., Eissa, Ibrahim H.

“…[Display omitted] •Twenty-four compounds of novel quinazolin-4(3H)-one derivatives were designed and synthesized.•Cytotoxic activities were evaluated against…”
Get full text

Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibitors by Burmaoglu, Serdar, Yilmaz, Ali Osman, Polat, M. Fatih, Kaya, Rüya, Gulcin, İlhami, Algul, Oztekin

“…[Display omitted] •The first synthesis of tris-chalcone derivatives 5a-i was realized.•All synthesized compounds have been characterized by 1H and 13C NMR, IR…”
Get full text

Novel 2-aminopyridine liganded Pd(II) N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure and bioactivity properties by Erdemir, Fatoş, Celepci, Duygu Barut, Aktaş, Aydın, Gök, Yetkin, Kaya, Ruya, Taslimi, Parham, Demir, Yeliz, Gulçin, İlhami

“…[Display omitted] •A serie of Novel 2-aminopyridine liganded Pd(II) N-Heterocyclic Carbene Complexes was synthesised.•These compounds have been characterized…”
Get full text

Promising anti-inflammatory effects of chalcones via inhibition of cyclooxygenase, prostaglandin E 2 , inducible NO synthase and nuclear factor κb activities by Ur Rashid, Haroon, Xu, Yiming, Ahmad, Nasir, Muhammad, Yaseen, Wang, Lisheng

“…Chalcones (1, 3-Diphenyl-2-propen-1-one) consist of a three carbon α, β-unsaturated carbonyl system and act as precursors for the biosynthesis of flavonoids in…”
Get full text