Search Results - "Biomeditsinskaia khimiia"

Approaches for improving L-asparaginase expression in heterologous systems by Gladilina, Yu A, Shishparenok, A N, Zhdanov, D D

“…L-asparaginase (EC 3.5.1.1) is one of the most demanded enzymes used in the pharmaceutical industry as a drug and in the food industry to prevent the formation…”
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Detection of low-copy proteins in proteomic studies: issues and solutions by Archakov, A I, Vavilov, N E, Zgoda, V G

“…Detection of low-copy proteins in complex biological samples is one of the most important issues of modern proteomics. The main reason for inefficient…”
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Nanowire-based biosensors for solving biomedical problems by Goldaeva, K V, Pleshakova, T O, Ivanov, Yu D

“…The review considers modern achievements and prospects of using nanowire biosensors, principles of their operation, methods of fabrication, and the influence…”
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AFM-fishing technology for protein detection in solutions by Pleshakova, T O, Ershova, M O, Valueva, A A, Ivanova, I A, Ivanov, Yu D, Archakov, A I

“…The review considers the possibility of using atomic force microscopy (AFM) as a basic method for protein detection in solutions with low protein…”
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The human proteome size as a technological development function by Sarygina, E V, Kozlova, A S, Ponomarenko, E A, Ilgisonis, E V

“…Changes in information on the number of human proteoforms, post-translational modification (PTM) events, alternative splicing (AS), single-amino acid…”
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In silico and in cellulo approaches for functional annotation of human protein splice variants by Kiseleva, O I, Arzumanian, V A, Kurbatov, I Yu, Poverennaya, E V

“…The elegance of pre-mRNA splicing mechanisms continues to interest scientists even after over a half century, since the discovery of the fact that coding…”
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Proteome of plasma extracellular vesicles as a source of colorectal cancer biomarkers by Soloveva, N A, Novikova, S E, Farafonova, T E, Tikhonova, O V, Zgoda, V G, Archakov, A I

“…The search for minimally invasive methods for diagnostics of colorectal cancer (CRC) is the most important task for early diagnostics of the disease and…”
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Biosensing platforms for DNA diagnostics based on CRISPR/Cas nucleases: towards the detection of nucleic acids at the level of single molecules in non-laboratory settings by Khmeleva, S A, Ptitsyn, K G, Kurbatov, L K, Timoshenko, O S, Suprun, E V, Radko, S P, Lisitsa, A V

“…The use of CRISPR/Cas nucleases for the development of DNA diagnostic systems in out-of-laboratory conditions (point-of-need testing, PONT) has demonstrated…”
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Registration of activity of a single molecule of horseradish peroxidase using a detector based on a solid-state nanopore by Ivanov, Yu D, Ableev, A N, Vinogradova, A V, Nevedrova, E D, Shumov, I D, Ziborov, V S, Kozlov, A F, Ivanova, I A, Vaulin, N V, Lebedev, D V, Bukatin, A S, Mukhin, I S, Ponomarenko, E A, Archakov, A I

“…This work demonstrates the use of a solid-state nanopore detector to monitor the activity of a single molecule of a model enzyme, horseradish peroxidase (HRP)…”
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Fundamentals of protein chemistry at the Institute of Biomedical Chemistry by Kolesnichenko, A V, Pleshakova, T O

“…Eighty years ago, the Institute of Biomedical Chemistry (IBMC) initially known as the Institute of Biological and Medical Chemistry of the Academy of Sciences…”
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Clinical metabolomics: current state and prospects in Russia by Lokhov, P G, Balashova, E E, Trifonova, O P, Maslov, D L, Lokhov, A P, Ponomarenko, E A, Lisitsa, A V, Ugrumov, M V, Stilidi, I S, Kushlinskii, N E, Nikityuk, D B, Tutelyan, V A, Shestakova, M V, Dedov, I I, Archakov, A I

“…Using analytical technologies it is possible now to measure the entire diversity of molecules even in a small amount of biological samples. Metabolomic…”
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MicroRNAs as promising diagnostic and prognostic markers for the human genitourinary cancer by Kugaevskaya, E V, Timoshenko, O S, Gureeva, T A, Radko, S P, Lisitsa, A V

“…Genitourinary cancer (GUC) represents more than one fifth of all human cancers. This makes the development of approaches to its early diagnosis an important…”
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Internalization of extracellular vesicles of cancer patients by peripheral blood mononuclear cells during polychemotherapy: connection with neurotoxicity by Yunusova, N V, Kaigorodova, E V, Panfilova, P A, Popova, N O, Udintseva, I N, Kondakova, I V, Svarovsky, D A, Goldberg, V E

“…Extracellular vesicles (EVs), exhibiting their functional activity after internalization by recipient cells, are involved in the pathogenesis of drug-induced…”
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The neuroprotective effect of isatin in the rotenone-induced model of parkinonism in rats: the study of delayed effects by Buneeva, O A, Kapitsa, I G, Kazieva, L Sh, Vavilov, N E, Zgoda, V G, Medvedev, A E

“…Parkinsonism in rats induced by the pesticide rotenone is one of the most adequate models of Parkinson's disease (PD). Isatin (indole-2,3-dione) is an…”
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Apoptotic endonuclease EndoG induces alternative splicing of Caspase-2 by Zhdanov, D D, Gladilina, Yu A, Shisparenok, A N

“…Caspase-2 (Casp-2) is an enzyme that regulates the development of apoptosis upon alternative splicing of its mRNA. The long form of Casp-2 (Casp-2L) promotes…”
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Molecular mechanisms of the regulatory action of high-density lipoproteins on the endothelial function by Poteryaeva, O N, Usynin, I F

“…Endothelial dysfunction underlies the pathogenesis of many diseases, primarily cardiovascular diseases. Epidemiological studies have shown an inverse…”
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Bioinformatic identification of proteins with altered PTM levels in a mouse line established to study the mechanisms of the development of fibromuscular dysplasia by Voronina, A I, Miroshnichenko, Yu V, Skvortsov, V S

“…Data from a mass spectrometry experiment of a mouse line developed to study the mechanisms of fibromuscular dysplasia and deposited by d'Escamard et al. in…”
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Proteomic profiling of renal tissue of normo- and hypertensive rats with the renalase peptide RP220 as an affinity ligand by Buneeva, O A, Fedchenko, V I, Kaloshina, S A, Zavyalova, M G, Zgoda, V G, Medvedev, A E

“…Renalase (RNLS) is a recently discovered protein that plays an important role in the regulation of blood pressure by acting inside and outside cells…”
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The cytokine response of human coronary artery endothelial cells treated with doxorubicin: results of an in vitro experiment by Sinitskaya, A V, Velikanova, E A, Senokosova, E A, Sinitsky, M Yu, Khutornaya, M V, Asanov, M A, Poddubnyak, A O, Ponasenko, A V

“…The cytokine profile of primary coronary artery endothelial cells cultivated in the presence of doxorubicin (2 μg/ml and 6 μg/ml) was evaluated using…”
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Electrochemical profiling of poliovirus particles inactivated by chemical method and ionizing radiation by Agafonova, L E, Shumyantseva, V V, Ivin, Yu Yu, Piniaeva, A N, Kovpak, A A, Ishmukhametov, A A, Budnik, S V, Churyukin, R S, Zhdanov, D D, Archakov, A I

“…Electrochemical profiling of formaldehyde-inactivated poliovirus particles demonstrated a relationship between the D-antigen concentration and the intensity of…”
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