Search Results - "Biomedical Research"

Microbiota-gut-brain axis: enteroendocrine cells and the enteric nervous system form an interface between the microbiota and the central nervous system by KUWAHARA, Atsukazu, MATSUDA, Kyoko, KUWAHARA, Yuko, ASANO, Shinji, INUI, Toshio, MARUNAKA, Yoshinori

“…The microbiota-gut-brain axis transmits bidirectional communication between the gut and the central nervous system and links the emotional and cognitive…”
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Immune checkpoint inhibitors in cancer therapy by Webb, Eika S, Liu, Peng, Baleeiro, Renato, Lemoine, Nicholas R, Yuan, Ming, Wang, Yao-He

“…In recent years immune checkpoint inhibitors have garnered attention as being one of the most promising types of immunotherapy on the horizon. There has been…”
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Hepatic ischemia-reperfusion injury in liver transplant setting: mechanisms and protective strategies by Rampes, Sanketh, Ma, Daqing

“…Hepatic ischemia-reperfusion injury is a major cause of liver transplant failure, and is of increasing significance due to increased use of expanded criteria…”
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Bacterial nanocellulose production and biomedical applications by Barja, François

“…Bacterial nanocellulose (BNC) is a homopolymer of β-1,4 linked glycose, which is synthesized by using simple culturing methods to allow inexpensive and…”
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Postoperative sleep disorders and their potential impacts on surgical outcomes by Rampes, Sanketh, Ma, Katie, Divecha, Yasmin Amy, Alam, Azeem, Ma, Daqing

“…Postoperative sleep disturbance is a common occurrence with significant adverse effects on patients including delayed recovery, impairment of cognitive…”
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Glutamate in cancers: from metabolism to signaling by Yi, Haowei, Talmon, Geoff, Wang, Jing

“…Glutamine and glutamate are major bioenergy substrates for normal and cancer cell growth. Cancer cells need more biofuel than normal tissues for energy supply,…”
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Exosomes and their role in the micro-/macro-environment: a comprehensive review by Javeed, Naureen, Mukhopadhyay, Debabrata

“…The importance of extracellular vesicles (EVs) in cell-cell communication has long been recognized due to their ability to transfer important cellular cargoes…”
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Melanoma therapeutics: a literature review by Dhanyamraju, Pavan Kumar, Patel, Trupti N

“…Melanoma is a relentless type of skin cancer which involves myriad signaling pathways which regulate many cellular processes. This makes melanoma difficult to…”
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Improvement of cognitive functions by oral intake of Hericium erinaceus by SAITSU, Yuusuke, NISHIDE, Akemi, KIKUSHIMA, Kenji, SHIMIZU, Kuniyoshi, OHNUKI, Koichiro

“…Hericium erinaceus has been recognized as medical mushroom since ancient time, but its scientific evidence for human health has been still uncertain. In this…”
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Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse by ASHIZAWA, Tadashi, IIZUKA, Akira, TANAKA, Emiko, KONDOU, Ryota, MIYATA, Haruo, MAEDA, Chie, SUGINO, Takashi, YAMAGUCHI, Ken, ANDO, Takayuki, ISHIKAWA, Yoshinobu, ITO, Mamoru, AKIYAMA, Yasuto

“…Recently, the first series of small molecule inhibitors of PD-1/PD-L1 were reported by Bristol-Myers Squibb (BMS), which were developed using a homogeneous…”
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Histone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers by Sanaei, Masumeh, Kavoosi, Fraidoon

“…Epigenetic modifications such as histone modification play an important role in tumorigenesis. There are several evidence that histone deacetylases (HDACs)…”
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Target specificity of selective bioactive compounds in blocking α-dystroglycan receptor to suppress Lassa virus infection: an in silico approach by Arefin, Adittya, Ismail Ema, Tanzila, Islam, Tamnia, Saddam Hossen, Md, Islam, Tariqul, Al Azad, Salauddin, Nasir Uddin Badal, Md, Aminul Islam, Md, Biswas, Partha, Alam, Nafee Ul, Islam, Enayetul, Anjum, Maliha, Masud, Afsana, Shaikh Kamran, Md, Rahman, Ahsab, Kumar Paul, Parag

“…Lassa hemorrhagic fever, caused by Lassa mammarenavirus (LASV) infection, accumulates up to 5000 deaths every year. Currently, there is no vaccine available to…”
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Postprandial hyperglycemia and postprandial hypertriglyceridemia in type 2 diabetes by Hiyoshi, Toru, Fujiwara, Mutsunori, Yao, Zemin

“…Postprandial glucose level is an independent risk factor for cardiovascular disease that exerts effects greater than glucose levels at fasting state, whereas…”
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Quercetin protects human coronary artery endothelial cells against hypoxia/reoxygenation-induced mitochondrial apoptosis via the Nrf2/HO-1 axis by Song, Jiejin, Li, Shuang, Zhang, Boyong, Wu, Jiao, Zhong, Aiqin

“…Our study explored the therapeutic effect and the mechanism of quercetin against hypoxia/reoxygenation (H/R)-induced injury in human coronary artery…”
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Efficacy of 1,5-anhydro-D-fructose on reducing mental stress: a randomized, double-blind, placebo-controlled trial-a pilot study by Kikuchi, Kiyoshi, Kiyama, Ryoji, Yoshinaga, Kazuhiro

“…Brain-derived neurotrophic factor (BDNF) plays an important role in mental stress. We have previously reported that 1,5-anhydro-D-fructose (1,5-AF) increases…”
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Identification of membrane proteins targeted by small-molecule compounds using nanomagnetic beads by Kikuchi, Yasufumi, Ando, Takayuki, Ashizawa, Tadashi, Iizuka, Akira, Kanematsu, Akari, Maeda, Chie, Hozumi, Chikako, Miyata, Haruo, Yamashita, Kazue, Ikeya, Tomoatsu, Yamaguchi, Ken, Akiyama, Yasuto

“…In drug discovery research, it is important to identify target proteins of bioactive small-molecule compounds and analyse their functions. In this study, we…”
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Bone regeneration-enhancing effects of extremely low-frequency electromag- netic fields: Analysis using fish scales as a bone model by Suzuki, Nobuo, Kakikawa, Makiko, Oda, Yuta, Kobayashi-Sun, Jingjing, Yamada, Sotoshi, Kuroda, Kouhei, Kobayashi, Isao, Honda, Masato, Matsubara, Hajime, Tabuchi, Yoshiaki, Shimizu, Nobuaki, Watanabe, Kazuki, Hirayama, Jun, Hattori, Atsuhiko

“…Electromagnetic fields (EMFs) noninvasively promote fracture healing, prevent osteoporosis, promote diaphyseal growth, enhance differentiation, and stimulate…”
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Linalyl acetate exerts analgesic effects by inhibiting nociceptive TRPA1 in mice by Hashimoto, Miho, Takahashi, Kenji, Unno, Toshihiro, Ohta, Toshio

“…Clary sage essential oil (CSEO) is utilized in perfumery, aromatherapy, and skincare. Linalyl acetate (LA), a primary component of CSEO, possesses sedative,…”
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Silibinin promotes melanogenesis through the PKA and p38 MAPK signaling pathways in melanoma cells by Uto, Takuhiro, Ohta, Tomoe, Katayama, Koki, Shoyama, Yukihiro

“…Silibinin is a flavonolignan isolated from milk thistle (Silybum marianum). Silibinin has been reported to possess multiple biological activities; however, its…”
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Copper-induced renal toxicity controlled by period1 through modulation of Atox1 in mice by Tominaga, Sarah, Yoshioka, Hiroki, Yokota, Satoshi, Tsukiboshi, Yosuke, Suzui, Masumi, Nagai, Makoto, Hara, Hirokazu, Miura, Nobuhiko, Maeda, Tohru

“…Copper (Cu) is known to induce oxidative stress and apoptosis in the liver, kidney, and brain. We previously demonstrated the molecular mechanism underlying…”
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