Search Results - "Biomaterials"

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy by Niu, Boyi, Liao, Kaixin, Zhou, Yixian, Wen, Ting, Quan, Guilan, Pan, Xin, Wu, Chuanbin

“…Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a high level of GSH is indispensable to scavenge excessive reactive…”
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Progress in 3D bioprinting technology for tissue/organ regenerative engineering by Matai, Ishita, Kaur, Gurvinder, Seyedsalehi, Amir, McClinton, Aneesah, Laurencin, Cato T.

“…Escalating cases of organ shortage and donor scarcity worldwide are alarming reminders of the need for alternatives to allograft tissues. Within the last three…”
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Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing by Qu, Jin, Zhao, Xin, Liang, Yongping, Zhang, Tianlong, Ma, Peter X., Guo, Baolin

“…Designing wound dressing materials with outstanding therapeutic effects, self-healing, adhesiveness and suitable mechanical property has great practical…”
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Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties by Tu, Chenxi, Lu, Huidan, Zhou, Tong, Zhang, Wanying, Deng, Liwen, Cao, Wangbei, Yang, Zhijian, Wang, Zhaolong, Wu, Xinyu, Ding, Jie, Xu, Feng, Gao, Changyou

“…The diabetic wound is easily to develop into a chronic wound because of the extremely serious and complex inflammatory microenvironment including biofilm…”
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ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds by Zhao, He, Huang, Jie, Li, Yan, Lv, Xinjing, Zhou, Huiting, Wang, Hairong, Xu, Yunyun, Wang, Chao, Wang, Jian, Liu, Zhuang

“…Bacterial infection has been a great threat to dermal wounds, especially to difficult-to-heal diabetic wounds. It is known that reactive oxygen species (ROS)…”
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Advances in nanomaterials for photodynamic therapy applications: Status and challenges by Chen, Jianming, Fan, Taojian, Xie, Zhongjian, Zeng, Qiqiao, Xue, Ping, Zheng, Tingting, Chen, Yun, Luo, Xiaoling, Zhang, Han

“…Photodynamic therapy (PDT), as a non-invasive therapeutic modality that is alternative to radiotherapy and chemotherapy, is extensively investigated for cancer…”
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Metal-organic frameworks for stimuli-responsive drug delivery by Wang, Ying, Yan, Jianhua, Wen, Nachuan, Xiong, Hongjie, Cai, Shundong, He, Qunye, Hu, Yaqin, Peng, Dongming, Liu, Zhenbao, Liu, Yanfei

“…Metal-organic framework (MOF), a novel hybrid porous material which is composited by metal ions and organic linkers, has drawn increasing attention and became…”
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Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives by Ho-Shui-Ling, Antalya, Bolander, Johanna, Rustom, Laurence E., Johnson, Amy Wagoner, Luyten, Frank P., Picart, Catherine

“…Bone fractures are the most common traumatic injuries in humans. The repair of bone fractures is a regenerative process that recapitulates many of the…”
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Mesenchymal stem cell-macrophage crosstalk and bone healing by Pajarinen, Jukka, Lin, Tzuhua, Gibon, Emmanuel, Kohno, Yusuke, Maruyama, Masahiro, Nathan, Karthik, Lu, Laura, Yao, Zhenyu, Goodman, Stuart B.

“…Recent research has brought about a clear understanding that successful fracture healing is based on carefully coordinated cross-talk between inflammatory and…”
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Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing by Zhao, Xin, Wu, Hao, Guo, Baolin, Dong, Ruonan, Qiu, Yusheng, Ma, Peter X

“…Abstract Injectable self-healing hydrogel dressing with multifunctional properties including anti-infection, anti-oxidative and conductivity promoting wound…”
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A physicochemical double cross-linked multifunctional hydrogel for dynamic burn wound healing: shape adaptability, injectable self-healing property and enhanced adhesion by Yuan, Yang, Shen, Shihong, Fan, Daidi

“…Burn wounds are one of the most destructive skin traumas that cause more than 180000 deaths each year. Patients with large, irregular burn wounds suffer from…”
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Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment by Zhou, Wenxi, Zhou, Yu, Chen, Xinli, Ning, Tingting, Chen, Hongyi, Guo, Qin, Zhang, Yiwen, Liu, Peixin, Zhang, Yujie, Li, Chao, Chu, Yongchao, Sun, Tao, Jiang, Chen

“…Immunotherapy has gained increasing focus in treating pancreatic ductal adenocarcinoma (PDAC), since conventional therapies like chemotherapy could not provide…”
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Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy by Tian, Tian, Zhang, Hui-Xin, He, Chun-Peng, Fan, Song, Zhu, Yan-Liang, Qi, Cui, Huang, Ning-Ping, Xiao, Zhong-Dang, Lu, Zu-Hong, Tannous, Bakhos A., Gao, Jun

“…The safe and effective delivery of drugs is a major obstacle in the treatment of ischemic stroke. Exosomes hold great promise as an endogenous drug delivery…”
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M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages by Gunassekaran, Gowri Rangaswamy, Poongkavithai Vadevoo, Sri Murugan, Baek, Moon-Chang, Lee, Byungheon

“…M2-polarized, pro-tumoral tumor-associated macrophages (TAMs) express the interleukin-4 receptor (IL4R) at higher levels compared with M1-polarized,…”
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Nanomaterial-based blood-brain-barrier (BBB) crossing strategies by Xie, Jinbing, Shen, Zheyu, Anraku, Yasutaka, Kataoka, Kazunori, Chen, Xiaoyuan

“…Increasing attention has been paid to the diseases of central nervous system (CNS). The penetration efficiency of most CNS drugs into the brain parenchyma is…”
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Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing by Shiekh, Parvaiz A., Singh, Anamika, Kumar, Ashok

“…Lack of oxygen, reduced vascularization, elevated oxidative stress, and infection are critical clinical hallmarks of non-healing chronic diabetic wounds…”
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3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes by Campisi, Marco, Shin, Yoojin, Osaki, Tatsuya, Hajal, Cynthia, Chiono, Valeria, Kamm, Roger D.

“…The blood-brain barrier (BBB) regulates molecular trafficking, protects against pathogens, and prevents efficient drug delivery to the brain. Models to date…”
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NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo by Jia, Gang, Han, Yong, An, Yanli, Ding, Yinan, He, Chen, Wang, Xihui, Tang, Qiusha

“…Currently, glioma treatment is limited by two main factors: timely detection at onset or relapse and restriction of drugs by the blood-brain barrier (BBB) from…”
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MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity by Zhang, Shipin, Chuah, Shang Jiunn, Lai, Ruenn Chai, Hui, James Hoi Po, Lim, Sai Kiang, Toh, Wei Seong

“…Mesenchymal stem cell (MSC) exosome was previously shown to be effective in repairing critical size osteochondral defects in an immunocompetent rat model. Here…”
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Emerging and innovative approaches for wound healing and skin regeneration: Current status and advances by Chouhan, Dimple, Dey, Namit, Bhardwaj, Nandana, Mandal, Biman B.

“…Current advances in skin tissue engineering and wound healing augur well for the development of split or full thickness skin substitutes to recapitulating the…”
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