Search Results - "Biological psychiatry (1969)"

The β-Secretase BACE1 in Alzheimer’s Disease by Hampel, Harald, Vassar, Robert, De Strooper, Bart, Hardy, John, Willem, Michael, Singh, Neeraj, Zhou, John, Yan, Riqiang, Vanmechelen, Eugeen, De Vos, Ann, Nisticò, Robert, Corbo, Massimo, Imbimbo, Bruno Pietro, Streffer, Johannes, Voytyuk, Iryna, Timmers, Maarten, Tahami Monfared, Amir Abbas, Irizarry, Michael, Albala, Bruce, Koyama, Akihiko, Watanabe, Naoto, Kimura, Teiji, Yarenis, Lisa, Lista, Simone, Kramer, Lynn, Vergallo, Andrea

“…BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all…”
Get full text

Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium by Walton, Esther, Jiang, Wenhao, Yao, Nailin, Fukunaga, Masaki, Hashimoto, Ryota, Okada, Naohiro, Bustillo, Juan R., de Zwarte, Sonja M.C., Hulshoff Pol, Hilleke E., Andreassen, Ole A., Dale, Anders M., Doan, Nhat Trung, Gurholt, Tiril P., Hartberg, Cecilie B., Jørgensen, Kjetil N., Melle, Ingrid, Westlye, Lars T., Gruber, Oliver, Kraemer, Bernd, Tordesillas-Gutiérrez, Diana, Fullerton, Janice M., Green, Melissa J., Henskens, Frans A., Quidé, Yann, Schall, Ulrich, Scott, Rodney J., Cairns, Murray J., Tooney, Paul A., Rasser, Paul E., Cooper, Gavin, Morris, Derek W., Hong, Elliot, Gur, Ruben C., Satterthwaite, Theodore D., Wolf, Daniel H., Mathalon, Daniel H., Potkin, Steven G., Preda, Adrian, Voyvodic, James, Lim, Kelvin O., McEwen, Sarah, Tan, Yunlong, Fan, Fengmei, Guo, Hua, Wan, Ping, Bockholt, Henry J., Ehrlich, Stefan, Wolthusen, Rick P.F., King, Margaret D., De Haan, Lieuwe, de Rossi, Pietro, Iorio, Mariangela, McKenna, Peter J., Pomarol-Clotet, Edith, Kelly, Sinead, Whelan, Christopher D., Voineskos, Aristotle N., Ciufolini, Simone, Radua, Joaquim, Dazzan, Paola, Murray, Robin, Reis Marques, Tiago, Simmons, Andrew, Egloff, Laura, Harrisberger, Fabienne, Riecher-Rössler, Anita, Alpert, Kathryn I., Koops, Sanne, Bertolino, Alessandro, Bonvino, Aurora, Di Giorgio, Annabella, Stephen, Julia M., Cannon, Dara M., McDonald, Colm, Lebedeva, Irina, Tomyshev, Alexander S., Akhadov, Tolibjohn, Farde, Lars, Flyckt, Lena, Erhardt, Sophie, Schwieler, Lilly, Agartz, Ingrid, Collste, Karin, Victorsson, Pauliina, Orhan, Funda, Busatto, Geraldo F., Rosa, Pedro G.P., Zanetti, Marcus V., Skoch, Antonin, Spaniel, Filip, Tomecek, David, Hagenaars, Saskia P., McIntosh, Andrew M., Oertel-Knöchel, Viola, Uhlmann, Anne, Lopez-Jaramillo, Carlos, McMahon, Agnes, Faskowitz, Joshua I., Thompson, Paul M., Turner, Jessica A.

“…The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies…”
Get full text

The Predictive Coding Account of Psychosis by Sterzer, Philipp, Adams, Rick A., Fletcher, Paul, Frith, Chris, Lawrie, Stephen M., Muckli, Lars, Petrovic, Predrag, Uhlhaas, Peter, Voss, Martin, Corlett, Philip R.

“…Fueled by developments in computational neuroscience, there has been increasing interest in the underlying neurocomputational mechanisms of psychosis. One…”
Get full text

Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression by Milaneschi, Yuri, Lamers, Femke, Berk, Michael, Penninx, Brenda W.J.H.

“…Epidemiological evidence indicates the presence of dysregulated homeostatic biological pathways in depressed patients, such as increased inflammation and…”
Get full text

Sensitive Periods for the Effect of Childhood Adversity on DNA Methylation: Results From a Prospective, Longitudinal Study by Dunn, Erin C., Soare, Thomas W., Zhu, Yiwen, Simpkin, Andrew J., Suderman, Matthew J., Klengel, Torsten, Smith, Andrew D.A.C., Ressler, Kerry J., Relton, Caroline L.

“…Exposure to early-life adversity is known to predict DNA methylation (DNAm) patterns that may be related to psychiatric risk. However, few studies have…”
Get full text

Intranasal Oxytocin: Myths and Delusions by Leng, Gareth, Ludwig, Mike

“…Abstract Despite widespread reports that intranasal application of oxytocin has a variety of behavioral effects, very little of the huge amounts applied…”
Get full text

Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls by Bot, Mariska, Milaneschi, Yuri, Al-Shehri, Tahani, Amin, Najaf, Garmaeva, Sanzhima, Onderwater, Gerrit L.J., Pool, Rene, Thesing, Carisha S., Vijfhuizen, Lisanne S., Vogelzangs, Nicole, Arts, Ilja C.W., Demirkan, Ayse, van Duijn, Cornelia, van Greevenbroek, Marleen, van der Kallen, Carla J.H., Köhler, Sebastian, Ligthart, Lannie, van den Maagdenberg, Arn M.J.M., Mook-Kanamori, Dennis O., de Mutsert, Renée, Tiemeier, Henning, Schram, Miranda T., Stehouwer, Coen D.A., Terwindt, Gisela M., Willems van Dijk, Ko, Fu, Jingyuan, Zhernakova, Alexandra, Beekman, Marian, Slagboom, P. Eline, Boomsma, Dorret I., Penninx, Brenda W.J.H., Beekman, M., Suchiman, H.E.D., Deelen, J., Amin, N., Beulens, J.W., van der Bom, J.A., Bomer, N., Demirkan, A., van Hilten, J.A., Meessen, J.M.T.A., Pool, R., Moed, M.H., Fu, J., Onderwater, G.L.J., Rutters, F., So-Osman, C., van der Flier, W.M., van der Heijden, A.A.W.A., van der Spek, A., Asselbergs, F.W., Boersma, E., Elders, P.M., Geleijnse, J.M., Ikram, M.A., Kloppenburg, M., Meulenbelt, I., Mooijaart, S.P., Nelissen, R.G.H.H., Netea, M.G., Penninx, B.W.J.H., Stehouwer, C.D.A., Teunissen, C.E., Terwindt, G.M., ’t Hart, L.M., van den Maagdenberg, A.M.J.M., van der Harst, P., van der Horst, I.C.C., van der Kallen, C.J.H., van Greevenbroek, M.M.J., van Spil, W.E., Wijmenga, C., Zwinderman, A.H., Zhernikova, A., Jukema, J.W., Sattar, N.

“…Depression has been associated with metabolic alterations, which adversely impact cardiometabolic health. Here, a comprehensive set of metabolic markers,…”
Get full text

The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls by de Leeuw, Christiaan A., McQuillin, Andrew, Ripke, Stephan, Trzaskowski, Maciej, Agerbo, Esben, Alliey-Rodriguez, Ney, Andlauer, Till F.M., Awasthi, Swapnil, Badner, Judith A., Bækvad-Hansen, Marie, Bøen, Erlend, Castelao, Enrique, Cerrato, Felecia, Cervantes, Pablo, Colodro-Conde, Lucía, Davies, Gail, Del-Favero, Jurgen, Dumont, Ashley, Fischer, Sascha B., Foo, Jerome C., Forty, Liz, Gordon, Scott D., Green, Melissa J., Grove, Jakob, Hansen, Christine Søholm, Hansen, Thomas F., Heilbronner, Urs, van Hemert, Albert M., Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Jamain, Stéphane, Jansen, Rick, Johnson, Jessica S., de Jong, Simone, Hassan Kiadeh, Farnush Farhadi, Kraft, Julia, Krogh, Jesper, Lawson, William B., Li, Yihan, Maaser, Anna, MacKinnon, Dean F., Mahon, Pamela B., Maier, Robert M., Medland, Sarah E., Mehta, Divya, Mihailov, Evelin, Montgomery, Grant W., Mullins, Niamh, Nyholt, Dale R., Ösby, Urban, Peterson, Roseann E., Pistis, Giorgio, Reinbold, Céline S., Ryu, Euijung, Schoevers, Robert, Schork, Nicholas J., Schulte, Eva C., Shehktman, Tatyana, Streit, Fabian, Thompson, Robert C., Traylor, Matthew, Vedder, Helmut, Viktorin, Alexander, Visscher, Peter M., Watson, Stanley J., Weinsheimer, Shantel Marie, Wu, Yang, Zhang, Peng, Agartz, Ingrid, Backlund, Lena, Bellivier, Frank, Blackwood, Douglas H.R., Domenici, Enrico, Fullerton, Janice M., Goes, Fernando, Hayward, Caroline, Hultman, Christina M., Jones, Ian, Kahn, René S., Kloiber, Stefan, Leboyer, Marion, Li, Qingqin S., Lucae, Susanne, Madden, Pamela A.F., Magnusson, Patrik K., Martin, Nicholas G., Mortensen, Preben Bo, Neale, Benjamin M., Nordentoft, Merete, O'Donovan, Michael C., Pato, Carlos, Pato, Michele T., Penninx, Brenda W.J. H., Posthuma, Danielle, Stefansson, Kari, Vieta, Eduard, Di Florio, Arianna, Ophoff, Roel A., Wray, Naomi R.

“…Mood disorders (including major depressive disorder and bipolar disorder) affect 10% to 20% of the population. They range from brief, mild episodes to severe,…”
Get full text

Maternal Systemic Interleukin-6 During Pregnancy is Associated with Newborn Amygdala Phenotypes and Subsequent Behavior at 2-years-of-age by Graham, Alice M, Rasmussen, Jerod M, Rudolph, Marc D, Heim, Christine M, Gilmore, John H, Styner, Martin, Potkin, Steven G, Entringer, Sonja, Wadhwa, Pathik D, Fair, Damien A, Buss, Claudia

“…Abstract Background Maternal inflammation during pregnancy increases risk for offspring psychiatric disorders and other adverse long-term health outcomes. The…”
Get full text

Peripheral Blood Cell–Stratified Subgroups of Inflamed Depression by Lynall, Mary-Ellen, Turner, Lorinda, Bhatti, Junaid, Cavanagh, Jonathan, de Boer, Peter, Mondelli, Valeria, Jones, Declan, Drevets, Wayne C., Cowen, Philip, Harrison, Neil A., Pariante, Carmine M., Pointon, Linda, Clatworthy, Menna R., Bullmore, Edward

“…Depression has been associated with increased inflammatory proteins, but changes in circulating immune cells are less well defined. We used multiparametric…”
Get full text

Subgenual Functional Connectivity Predicts Antidepressant Treatment Response to Transcranial Magnetic Stimulation: Independent Validation and Evaluation of Personalization by Cash, Robin F.H., Zalesky, Andrew, Thomson, Richard H., Tian, Ye, Cocchi, Luca, Fitzgerald, Paul B.

Get full text

Association Between Cannabis and Psychosis: Epidemiologic Evidence by Gage, Suzanne H, Hickman, Matthew, Zammit, Stanley

“…Abstract Associations between cannabis use and psychotic outcomes are consistently reported, but establishing causality from observational designs can be…”
Get full text

Maternal Cortisol Concentrations During Pregnancy and Sex-Specific Associations With Neonatal Amygdala Connectivity and Emerging Internalizing Behaviors by Graham, Alice M., Rasmussen, Jerod M., Entringer, Sonja, Ben Ward, Elizabeth, Rudolph, Marc D., Gilmore, John H., Styner, Martin, Wadhwa, Pathik D., Fair, Damien A., Buss, Claudia

“…Maternal cortisol during pregnancy has the potential to influence rapidly developing fetal brain systems that are commonly altered in neurodevelopmental and…”
Get full text

Maternal Inflammation and Neurodevelopmental Programming: A Review of Preclinical Outcomes and Implications for Translational Psychiatry by Gumusoglu, Serena B., Stevens, Hanna E.

“…Early disruptions to neurodevelopment are highly relevant to understanding both psychiatric risk and underlying pathophysiology that can be targeted by new…”
Get full text

Adult Hippocampal Neurogenesis Is Regulated by the Microbiome by Ogbonnaya, Ebere S, Clarke, Gerard, Shanahan, Fergus, Dinan, Timothy G, Cryan, John F, O’Leary, Olivia F

Get full text

Opposing Effects on NaV1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures by Ben-Shalom, Roy, Keeshen, Caroline M., Berrios, Kiara N., An, Joon Y., Sanders, Stephan J., Bender, Kevin J.

“…Variants in the SCN2A gene that disrupt the encoded neuronal sodium channel NaV1.2 are important risk factors for autism spectrum disorder (ASD), developmental…”
Get full text

Depression, Neuroimaging and Connectomics: A Selective Overview by Gong, Qiyong, He, Yong

“…Abstract Depression is a multifactorial disorder with clinically heterogeneous features involving disturbances of mood and cognitive function. Noninvasive…”
Get full text

Prenatal Poly(I:C) Exposure and Other Developmental Immune Activation Models in Rodent Systems by Meyer, Urs

“…It is increasingly appreciated that altered neuroimmune mechanisms might play a role in the development of schizophrenia and related psychotic illnesses. On…”
Get full text

Psilocybin Induces Time-Dependent Changes in Global Functional Connectivity by Preller, Katrin H., Duerler, Patricia, Burt, Joshua B., Ji, Jie Lisa, Adkinson, Brendan, Stämpfli, Philipp, Seifritz, Erich, Repovš, Grega, Krystal, John H., Murray, John D., Anticevic, Alan, Vollenweider, Franz X.

“…The use of psilocybin in scientific and experimental clinical contexts has triggered renewed interest in the mechanism of action of psychedelics. However, its…”
Get full text

Deep Brain Stimulation for Depression Informed by Intracranial Recordings by Sheth, Sameer A., Bijanki, Kelly R., Metzger, Brian, Allawala, Anusha, Pirtle, Victoria, Adkinson, Joshua A., Myers, John, Mathura, Raissa K., Oswalt, Denise, Tsolaki, Evangelia, Xiao, Jiayang, Noecker, Angela, Strutt, Adriana M., Cohn, Jeffrey F., McIntyre, Cameron C., Mathew, Sanjay J., Borton, David, Goodman, Wayne, Pouratian, Nader

“…The success of deep brain stimulation (DBS) for treating Parkinson’s disease has led to its application to several other disorders, including…”
Get full text