Search Results - "Biological & pharmaceutical bulletin"

Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application by Yamashita, Takuma, Takahashi, Yuki, Takakura, Yoshinobu

“…Exosomes are cell-derived vesicles with a diameter 30–120 nm. Exosomes contain endogenous proteins and nucleic acids; delivery of these molecules to…”
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AMPK-Mediated Regulation of Lipid Metabolism by Phosphorylation by Wang, Qi, Liu, Shudong, Zhai, Aihua, Zhang, Bai, Tian, Guizhen

“…AMP-activated protein kinase (AMPK) is a metabolic sensor in mammals that is activated when ATP levels in the cell decrease. AMPK is a heterotrimeric protein…”
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Liposomal Delivery Systems: Design Optimization and Current Applications by Lila, Amr Selim Abu, Ishida, Tatsuhiro

“…The liposome, a closed phospholipid bilayered vesicular system, has received considerable attention as a pharmaceutical carrier of great potential over the…”
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Decreased Brain pH Underlies Behavioral and Brain Abnormalities Induced by Chronic Exposure to Glucocorticoids in Mice by Araki, Ryota, Kita, Ayami, Yabe, Takeshi

“…Depressed patients may exhibit glucocorticoid hypersecretion, suggesting that elevated levels of glucocorticoids may play an important role in the…”
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Efficient Loading into and Controlled Release of Lipophilic Compound from Liposomes by Using Cyclodextrin as Novel Trapping Agent by Akaki, Sae, Hosokawa, Mika, Maeda, Saki, Kono, Yusuke, Maeda, Hideko, Ogawara, Ken-ichi

“…Lipid bilayer vesicles, liposomes are representative drug delivery carriers. High encapsulation efficiency and release control of drugs are essential for…”
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Sunflower Trypsin Monocyclic Inhibitor Selected for the Main Protease of SARS-CoV-2 by Phage Display by Ferreira, Graziele Cristina, Manzato, Verônica de Moraes, Okamoto, Debora Noma, Fernandes, Livia Rosa, Santos, Deivid Martins, Costa, Gabriel Cerqueira Alves, Silva, Fernando Allan Abreu, Torquato, Ricardo Jose Soares, Palmisano, Giuseppe, Juliano, Maria Aparecida, Tanaka, Aparecida Sadae

“…Main protease (Mpro), also known as 3-chymotrypsin-like protease (3CLpro), is a nonstructural protein (NSP5) of severe acute respiratory syndrome coronavirus 2…”
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Expression Profiles of Brain-Derived Neurotrophic Factor Splice Variants in the Hippocampus of Alzheimer’s Disease Model Mouse by Matsuoka, Yuka, Nakasone, Hibiki, Kasahara, Rento, Fukuchi, Mamoru

“…Dysregulation of brain-derived neurotrophic factor (BDNF) has been implicated in Alzheimer's disease (AD). In this study, we investigated the temporal dynamics…”
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Evaluating the Associated Hyperuricemia Risk with Sodium-Glucose Cotransporter 2 Inhibitors: A Sequence Symmetry Analysis Using the Japanese Administrative Claims Database by Yokoyama, Satoshi, Nakagawa, Chihiro, Uno, Takaya, Hosomi, Kouichi

“…Hyperuricemia is defined as high uric acid levels within the bloodstream and is commonly associated with gout, type 2 diabetes mellitus, and kidney disease…”
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Downregulation of Genes for Skeletal Muscle Extracellular Matrix Components by Cisplatin by Miyauchi, Yu, Kiyama, Miho, Soga, Shinki, Nanri, Hayato, Ogiwara, Takayuki, Yonamine, Shiori, Kon, Risako, Ikarashi, Nobutomo, Chiba, Yoshihiko, Hosoe, Tomoo, Sakai, Hiroyasu

“…The extracellular matrix (ECM) in skeletal muscle is involved in a variety of physiological functions beyond the mechanical support of muscle tissue, nerves,…”
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Hua-Zhuo-Jie-Du Decoction Combined with Cisplatin Inhibits the Development of Gastric Cancer Cells by Regulating Immune and Autophagy Signaling by Sun, Chun-xia, Li, De-hui, Xu, Ya-pei, Yang, Zhu-feng, Wei, Li-ying, Gao, Yue-ming, Liu, Yi, Yan, Cui-huan, Li, Yong-zhang

“…Host immunity and autophagy of cancer cells markedly impact the development of gastric cancer. Hua-Zhuo-Jie-Du decoction (TDP) has been used in gastritis…”
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New Drug Delivery Systems for Stable Oral Absorption: Theory, Strategies, and Applications by Onoue, Satomi

“…The oral dosage route still remains the most common and preferred route for drug administration due to convenient handling, high patient compliance, and…”
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Glabridin Alleviates Inflammation and Nociception in Rodents by Activating BKCa Channels and Reducing NO Levels by Parlar, Ali, Arslan, Seyfullah Oktay, Çam, Saliha Ayşenur

“…Inflammation, and the pain that accompanies it, is a natural response of the body. The licorice plant (Glycyrrhiza glabra) have demonstrated anti-inflammatory,…”
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Foreword by Noguchi, Kohji

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Group IVA Phospholipase A 2 in Collagen-Producing Cells Promotes High-Fat Diet-Induced Infiltration of Inflammatory Cells into the Liver by Upregulating the Expression of MCP-1 by Kishinaka, Saki, Kawashita, Eri, Nishizaki, Taichi, Ishihara, Keiichi, Akiba, Satoshi

“…Nonalcoholic steatohepatitis (NASH) is characterized by hepatic inflammation and fibrosis due to excessive fat accumulation. Monocyte chemoattractant protein-1…”
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Foreword by Noguchi, Kohji

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The Polyethyleneglycol Dilemma: Advantage and Disadvantage of PEGylation of Liposomes for Systemic Genes and Nucleic Acids Delivery to Tumors by Hatakeyama, Hiroto, Akita, Hidetaka, Harashima, Hideyoshi

“…Gene and nucleic acid therapy is expected to play a major role in the next generation of agents for cancer treatment. We have recently developed a…”
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Epigallocatechin-3-gallate alleviates ethanol-induced endothelia cells injury partly through alteration of NF-κB translocation and activation of the Nrf2 signaling pathway by Xu, Jie, Xu, Shouzhu, Luo, Jiayin, Zhang, Shihao, Wu, Dongdong, Yang, Qifan, Fang, Rourou, Shi, Chuandao, Liu, Qiling, Zhao, Jing

“…Ethanol (alcohol) is a risk factor that contributes to non-communicable diseases. Chronic abuse of ethanol is toxic to both the heart and overall health, and…”
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Effect of chronic ethanol consumption on exogenous glucose metabolism in rats using [1-13C], [2-13C], and [3-13C]glucose breath tests by Kashima, Naoyasu, Sasaki, Yosuke, Kawagoe, Naoyuki, Shigeta, Tomoyuki, Komatsu, Fumiya, Urita, Yoshihisa

“…The C3 carbon of glucose molecules becomes the C1 carbon of pyruvate molecules during glycolysis, and the C1 and C2 carbons of glucose molecules are…”
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Detoxification and Activating Blood Circulation Decoction Promotes Reendothelialization of Damaged Blood Vessels via VEGF Signaling Pathway Activation by miRNA-126 by Liu, Zhiming, Xie, Guangmie, Li, Zuwei, Luo, Hanbin, Zhou, Jianhong, Cheng, Jie, Wang, Xiaolin, Huang, Xiaoyan, Zou, Guohui

“…The occurrence of in-stent restenosis (ISR) poses a significant challenge for percutaneous coronary intervention (PCI). Thus, the promotion of vascular…”
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A morpholine derivative N-(4-morpholinomethylene)ethanesulfonamide induces ferroptosis in tumor cells by targeting NRF2 by Sun, Bingchun, Zhang, Ligang, Wu, Binhua, Luo, Xiping

“…Small molecule drugs containing morpholine-based moieties have become crucial candidates in the tumor targeted therapy strategies, but the specific molecular…”
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