Search Results - "Biogerontology (Dordrecht)"

d-Galactose-induced accelerated aging model: an overview by Azman, Khairunnuur Fairuz, Zakaria, Rahimah

“…To facilitate the process of aging healthily and prevent age-related health problems, efforts to properly understand aging mechanisms and develop effective and…”
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Sirtuins, a promising target in slowing down the ageing process by Grabowska, Wioleta, Sikora, Ewa, Bielak-Zmijewska, Anna

“…Ageing is a plastic process and can be successfully modulated by some biomedical approaches or pharmaceutics. In this manner it is possible to delay or even…”
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Age-related changes in skeletal muscle: changes to life-style as a therapy by McCormick, Rachel, Vasilaki, Aphrodite

“…As we age, there is an age-related loss in skeletal muscle mass and strength, known as sarcopenia. Sarcopenia results in a decrease in mobility and…”
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Lipid (per) oxidation in mitochondria: an emerging target in the ageing process? by Ademowo, O. S., Dias, H. K. I., Burton, D. G. A., Griffiths, H. R.

“…Lipids are essential for physiological processes such as maintaining membrane integrity, providing a source of energy and acting as signalling molecules to…”
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Seven knowledge gaps in modern biogerontology by Rattan, Suresh I. S.

“…About a year ago, members of the editorial board of Biogerontology were requested to respond to a query by the editor-in-chief of the journal as to what one…”
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Natural anti-aging skincare: role and potential by Ahmed, Idris Adewale, Mikail, Maryam Abimbola, Zamakshshari, Norhisam, Abdullah, Al-Shwyeh Hussah

“…The deterioration of the skin morphology and physiology is the first and earliest obvious harbinger of the aging process which is progressively manifested with…”
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Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies by Chaudhary, Mani Raj, Chaudhary, Sakshi, Sharma, Yogita, Singh, Thokchom Arjun, Mishra, Alok Kumar, Sharma, Shweta, Mehdi, Mohammad Murtaza

“…Aging accompanied by several age-related complications, is a multifaceted inevitable biological progression involving various genetic, environmental, and…”
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Gene expression hallmarks of cellular ageing by Frenk, Stephen, Houseley, Jonathan

“…Ageing leads to dramatic changes in the physiology of many different tissues resulting in a spectrum of pathology. Nonetheless, many lines of evidence suggest…”
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Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway by Kumar, Ravi, Sharma, Anamika, Kumari, Amita, Gulati, Ashu, Padwad, Yogendra, Sharma, Rohit

“…The phytochemical epigallocatechin gallate (EGCG) has been reported to alleviate age-associated immune disorders and organ dysfunction. However, information…”
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Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway by Sandri, M., Barberi, L., Bijlsma, A. Y., Blaauw, B., Dyar, K. A., Milan, G., Mammucari, C., Meskers, C. G. M., Pallafacchina, G., Paoli, A., Pion, D., Roceri, M., Romanello, V., Serrano, A. L., Toniolo, L., Larsson, L., Maier, A. B., Muñoz-Cánoves, P., Musarò, A., Pende, M., Reggiani, C., Rizzuto, R., Schiaffino, S.

“…During ageing skeletal muscles undergo a process of structural and functional remodelling that leads to sarcopenia, a syndrome characterized by loss of muscle…”
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β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1 by Bourgade, Karine, Garneau, Hugo, Giroux, Geneviève, Le Page, Aurélie Y., Bocti, Christian, Dupuis, Gilles, Frost, Eric H., Fülöp, Tamàs

“…Amyloid plaques, the hallmark of Alzheimer’s disease (AD), contain fibrillar β-amyloid (Aβ) 1-40 and 1-42 peptides. Herpes simplex virus 1 (HSV-1) has been…”
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Aging and age‐related diseases: from mechanisms to therapeutic strategies by Li, Zhe, Zhang, Zhenkun, Ren, Yikun, Wang, Yingying, Fang, Jiarui, Yue, Han, Ma, Shanshan, Guan, Fangxia

“…Aging is a physiological process mediated by numerous biological and genetic pathways, which are directly linked to lifespan and are a driving force for all…”
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Immunosenescence and cancer by Pawelec, Graham

“…Age is a major risk factor for solid cancers, hitherto conventionally viewed in the context of the cell biology of carcinogenesis. However, if cancers are…”
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Mitochondria-targeted senotherapeutic interventions by Atayik, Mehmet Can, Çakatay, Ufuk

“…Healthy aging is the art of balancing a delicate scale. On one side of the scale, there are the factors that make life difficult with aging, and on the other…”
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Metformin as a geroprotector: experimental and clinical evidence by Piskovatska, Veronika, Stefanyshyn, Nadiya, Storey, Kenneth B., Vaiserman, Alexander M., Lushchak, Oleh

“…Apart from being a safe, effective and globally affordable glucose-lowering agent for the treatment of diabetes, metformin has earned much credit in recent…”
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Physical activity in older age: perspectives for healthy ageing and frailty by McPhee, Jamie S., French, David P., Jackson, Dean, Nazroo, James, Pendleton, Neil, Degens, Hans

“…Regular physical activity helps to improve physical and mental functions as well as reverse some effects of chronic disease to keep older people mobile and…”
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Senescent cells: SASPected drivers of age-related pathologies by Ovadya, Yossi, Krizhanovsky, Valery

“…The progression of physiological ageing is driven by intracellular aberrations including telomere attrition, genomic instability, epigenetic alterations and…”
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Aging, frailty and age-related diseases by Fulop, T., Larbi, A., Witkowski, J. M., McElhaney, J., Loeb, M., Mitnitski, A., Pawelec, G.

“…The concept of frailty as a medically distinct syndrome has evolved based on the clinical experience of geriatricians and is clinically well recognizable…”
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Cancer and Alzheimer’s disease: intracellular pH scales the metabolic disorders by Schwartz, Laurent, Peres, Sabine, Jolicoeur, Mario, da Veiga Moreira, Jorgelindo

“…Alzheimer’s disease (AD) and cancer have much in common than previously recognized. These pathologies share common risk factors (inflammation and aging), with…”
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Aging, frailty and complex networks by Mitnitski, A. B., Rutenberg, A. D., Farrell, S., Rockwood, K.

“…When people age their mortality rate increases exponentially, following Gompertz’s law. Even so, individuals do not die from old age. Instead, they accumulate…”
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