Search Results - "Bioconjugate chemistry"

The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery by Smith, Samuel A, Selby, Laura I, Johnston, Angus P. R, Such, Georgina K

“…Many emerging therapies rely on the delivery of biological cargo into the cytosol. Nanoparticle delivery systems hold great potential to deliver these…”
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Bioorthogonal Chemistry and Its Applications by Bird, Robert E, Lemmel, Steven A, Yu, Xiang, Zhou, Qiongqiong Angela

“…Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional groups to explore and understand biology in living organisms. In this…”
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Nanodrug Delivery: Is the Enhanced Permeability and Retention Effect Sufficient for Curing Cancer? by Nakamura, Yuko, Mochida, Ai, Choyke, Peter L, Kobayashi, Hisataka

“…Nanotechnology offers several attractive design features that have prompted its exploration for cancer diagnosis and treatment. Nanosized drugs have a large…”
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Overcoming Endosomal Entrapment in Drug Delivery by Pei, Dehua, Buyanova, Marina

“…Intracellular delivery of biological agents such as peptides, proteins, and nucleic acids generally rely on the endocytic pathway as the major uptake…”
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Guide to Selecting a Biorecognition Element for Biosensors by Morales, Marissa A, Halpern, Jeffrey Mark

“…Biosensors are powerful diagnostic tools defined as having a biorecognition element for analyte specificity and a transducer for a quantifiable signal. There…”
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Filling in the Gaps between Nanozymes and Enzymes: Challenges and Opportunities by Zhou, Yibo, Liu, Biwu, Yang, Ronghua, Liu, Juewen

“…Using nanomaterials to mimic the function of protein enzymes is an interesting idea. Many nanomaterials have a similar size as enzymes and they also possess…”
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Insights into Active Targeting of Nanoparticles in Drug Delivery: Advances in Clinical Studies and Design Considerations for Cancer Nanomedicine by Pearce, Amanda K, O’Reilly, Rachel K

“…Nanomedicine is a promising strategy for improving clinical outcomes for cancer therapies, by improving drug efficacy through enhanced delivery to disease…”
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An Overview of Recent Advances in Biomedical Applications of Click Chemistry by Kaur, Jasleen, Saxena, Mokshika, Rishi, Narayan

“…Cu­(I)-catalyzed azide–alkyne cycloaddition (CuAAC) is a modular and bio-orthogonal approach that is being adopted for the efficient synthesis of organic and…”
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The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy by Francia, Valentina, Schiffelers, Raymond M, Cullis, Pieter R, Witzigmann, Dominik

“…Gene therapy holds great potential for treating almost any disease by gene silencing, protein expression, or gene correction. To efficiently deliver the…”
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Activating Drugs with Sound: Mechanisms Behind Sonodynamic Therapy and the Role of Nanomedicine by Choi, Victor, Rajora, Maneesha A, Zheng, Gang

“…Sonodynamic therapy (SDT) is a promising therapeutic platform for minimally invasive cancer treatment in which acoustically susceptible drug agents,…”
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Activatable Fluorescence Probes for “Turn-On” and Ratiometric Biosensing and Bioimaging: From NIR‑I to NIR-II by Chen, Chuan, Tian, Rui, Zeng, Yun, Chu, Chengchao, Liu, Gang

“…The greatest advantage of activatable fluorescence probes (AFPs) is the inherent responsiveness to manipulate spectroscopic properties by chemical/physical…”
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Squaraine Dyes: Molecular Design for Different Applications and Remaining Challenges by Ilina, Kristina, MacCuaig, William M, Laramie, Matthew, Jeouty, Jannatun N, McNally, Lacey R, Henary, Maged

“…Squaraine dyes are a class of organic dyes with strong and narrow absorption bands in the near-infrared. Despite high molar absorptivities and fluorescence…”
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NanoLuc: A Small Luciferase Is Brightening Up the Field of Bioluminescence by England, Christopher G, Ehlerding, Emily B, Cai, Weibo

“…The biomedical field has greatly benefited from the discovery of bioluminescent proteins. Currently, scientists employ bioluminescent systems for numerous…”
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Size-Dependent Protein–Nanoparticle Interactions in Citrate-Stabilized Gold Nanoparticles: The Emergence of the Protein Corona by Piella, Jordi, Bastús, Neus G, Puntes, Víctor

“…Surface modifications of highly monodisperse citrate-stabilized gold nanoparticles (AuNPs) with sizes ranging from 3.5 to 150 nm after their exposure to cell…”
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Biointerfacing and Applications of Cell Membrane-Coated Nanoparticles by Kroll, Ashley V, Fang, Ronnie H, Zhang, Liangfang

“…The cell membrane-coated nanoparticle is a biomimetic platform consisting of a nanoparticulate core coated with membrane derived from a cell, such as a red…”
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Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development by Agarwal, Paresh, Bertozzi, Carolyn R

“…Antibody–drug conjugates (ADCs) combine the specificity of antibodies with the potency of small molecules to create targeted drugs. Despite the simplicity of…”
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Practical Considerations, Challenges, and Limitations of Bioconjugation via Azide–Alkyne Cycloaddition by Pickens, Chad J, Johnson, Stephanie N, Pressnall, Melissa M, Leon, Martin A, Berkland, Cory J

“…Interrogating biological systems is often limited by access to biological probes. The emergence of “click chemistry” has revolutionized bioconjugate chemistry…”
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Bioconjugated Oligonucleotides: Recent Developments and Therapeutic Applications by Benizri, Sebastien, Gissot, Arnaud, Martin, Andrew, Vialet, Brune, Grinstaff, Mark W, Barthélémy, Philippe

“…Oligonucleotide-based agents have the potential to treat or cure almost any disease, and are one of the key therapeutic drug classes of the future…”
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Penetration and Uptake of Nanoparticles in 3D Tumor Spheroids by Tchoryk, Aleksandra, Taresco, Vincenzo, Argent, Richard H, Ashford, Marianne, Gellert, Paul R, Stolnik, Snow, Grabowska, Anna, Garnett, Martin C

“…Animal models are effective for assessing tumor localization of nanosystems but difficult to use for studying penetration beyond the vasculature. Here, we have…”
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Recent Advances in Molecular Imaging with Gold Nanoparticles by Bouché, Mathilde, Hsu, Jessica C, Dong, Yuxi C, Kim, Johoon, Taing, Kimberly, Cormode, David P

“…Gold nanoparticles (AuNP) have been extensively developed as contrast agents, theranostic platforms, and probes for molecular imaging. This popularity has…”
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