Search Results - "Biochimie"

The emergence of COVID-19 as a global pandemic: Understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2 by Muralidar, Shibi, Ambi, Senthil Visaga, Sekaran, Saravanan, Krishnan, Uma Maheswari

“…An acute respiratory disease caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that surfaced in China in late 2019, continues to spread…”
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Role of AKT and mTOR signaling pathways in the induction of epithelial-mesenchymal transition (EMT) process by Karimi Roshan, Mostafa, Soltani, Arash, Soleimani, Anvar, Rezaie Kahkhaie, Kolsoum, Afshari, Amir R., Soukhtanloo, Mohammad

“…Epithelial-mesenchymal transition (EMT) is a critical process in the development of many tissues and organs in multicellular organisms that its important role…”
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Role of AMPK mediated pathways in autophagy and aging by Ge, Yuchen, Zhou, Min, Chen, Cui, Wu, Xiaojian, Wang, Xiaobo

“…AMPK is an important kinase regulating energy homeostasis and also a key protein involved in a variety of signal transduction pathways. It plays a vitally…”
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SELEX methods on the road to protein targeting with nucleic acid aptamers by Bayat, Payam, Nosrati, Rahim, Alibolandi, Mona, Rafatpanah, Houshang, Abnous, Khalil, Khedri, Mostafa, Ramezani, Mohammad

“…Systematic evolution of ligand by exponential enrichment (SELEX) is an efficient method used to isolate high-affinity single stranded oligonucleotides from a…”
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The role and regulation of the peroxisome proliferator activated receptor alpha in human liver by Kersten, Sander, Stienstra, Rinke

“…The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that is abundantly expressed in liver. PPARα is activated…”
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Adipocyte lipolysis and insulin resistance by Morigny, Pauline, Houssier, Marianne, Mouisel, Etienne, Langin, Dominique

“…Obesity-induced insulin resistance is a major risk factor for the development of type 2 diabetes. Basal fat cell lipolysis (i.e., fat cell triacylglycerol…”
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TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections by Shen, Li Wen, Mao, Hui Juan, Wu, Yan Ling, Tanaka, Yoshimasa, Zhang, Wen

“…Influenza virus and coronavirus epidemics or pandemics have occurred in succession worldwide throughout the early 21st century. These epidemics or pandemics…”
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Apaf-1: Regulation and function in cell death by Shakeri, Raheleh, Kheirollahi, Asma, Davoodi, Jamshid

“…Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or unnecessary cells in multicellular organisms. Various types of…”
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The key role of Warburg effect in SARS-CoV-2 replication and associated inflammatory response by Icard, Philippe, Lincet, Hubert, Wu, Zherui, Coquerel, Antoine, Forgez, Patricia, Alifano, Marco, Fournel, Ludovic

“…Current mortality due to the Covid-19 pandemic (approximately 1.2 million by November 2020) demonstrates the lack of an effective treatment. As replication of…”
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Metabolic endotoxemia with obesity: Is it real and is it relevant? by Boutagy, Nabil E., McMillan, Ryan P., Frisard, Madlyn I., Hulver, Matthew W.

“…Obesity is associated with metabolic derangements in multiple tissues, which contribute to the progression of insulin resistance and the metabolic syndrome…”
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PPARs and nonalcoholic fatty liver disease by Liss, Kim H.H., Finck, Brian N.

“…Nonalcoholic fatty liver disease (NAFLD) encompasses a range of liver pathology ranging from simple steatosis to varying degrees of inflammation, hepatocyte…”
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Impact of high-fat diet on the intestinal microbiota and small intestinal physiology before and after the onset of obesity by Araújo, João Ricardo, Tomas, Julie, Brenner, Christiane, Sansonetti, Philippe J.

“…The modulation of the intestinal microbiota by high-fat diet (HFD) has a major impact on both immunological and metabolic functions of the host. Taking this…”
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Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug by Zhang, Xiaonan, Selvaraju, Karthik, Saei, Amir Ata, D'Arcy, Padraig, Zubarev, Roman A., Arnér, Elias SJ, Linder, Stig

“…Auranofin is a gold (I)-containing compound used for the treatment of rheumatic arthritis. Auranofin has anticancer activity in animal models and is approved…”
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May omega-3 fatty acid dietary supplementation help reduce severe complications in Covid-19 patients? by Weill, Pierre, Plissonneau, Claire, Legrand, Philippe, Rioux, Vincent, Thibault, Ronan

“…In around 10% of SARS-CoV-2 infected patients, coronavirus disease-2019 (Covid-19) symptoms are complicated with a severe lung damage called Acute Respiratory…”
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The 5-HT1A receptor: Signaling to behavior by Albert, Paul R., Vahid-Ansari, Faranak

“…The 5-HT1A receptor is highly expressed both in 5-HT neurons as a presynaptic inhibitory autoreceptor, and in many brain regions innervated by 5-HT as a…”
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SIRT1/PGC-1 pathway activation triggers autophagy/mitophagy and attenuates oxidative damage in intestinal epithelial cells by Liang, Danyang, Zhuo, Yisha, Guo, Zeheng, He, Lihua, Wang, Xueyi, He, Yulong, Li, Lexing, Dai, Hanchuan

“…Oxidative stress leads to intestinal epithelial cells damage, which induces tight junction injury and systemic endogenous stress syndrome. The evidence…”
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Eicosapentaenoic and docosahexaenoic acid derived specialised pro-resolving mediators: Concentrations in humans and the effects of age, sex, disease and increased omega-3 fatty acid intake by Calder, Philip C.

“…Although inflammation has a physiological role, unrestrained inflammation can be detrimental, causing tissue damage and disease. Under normal circumstances…”
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Palmatine: A review of its pharmacology, toxicity and pharmacokinetics by Long, Jiaying, Song, Jiawen, Zhong, Li, Liao, Yanmei, Liu, Luona, Li, Xiaofang

“…Palmatine is a natural isoquinoline alkaloid and has been widely used in pharmaceutical field. The purpose of this review is to provide the latest and…”
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Potential role and therapeutic interests of myo-inositol in metabolic diseases by Croze, Marine L., Soulage, Christophe O.

“…Several inositol isomers and in particular myo-inositol (MI) and D-chiro-inositol (DCI), were shown to possess insulin-mimetic properties and to be efficient…”
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Strategies in the design of endosomolytic agents for facilitating endosomal escape in nanoparticles by Ahmad, Aqeel, Khan, Javed Masood, Haque, Shafiul

“…Nanoparticles (NPs) are one of the leading and promising technologies for gene and drug delivery. However, despite continuous advancements in the delivery of…”
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