Search Results - "Biochimica et biophysica acta. Molecular basis of disease"

Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach by Naqvi, Ahmad Abu Turab, Fatima, Kisa, Mohammad, Taj, Fatima, Urooj, Singh, Indrakant K., Singh, Archana, Atif, Shaikh Muhammad, Hariprasad, Gururao, Hasan, Gulam Mustafa, Hassan, Md. Imtaiyaz

“…The sudden emergence of severe respiratory disease, caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently become a…”
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The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling by Shinde, Arti V., Humeres, Claudio, Frangogiannis, Nikolaos G.

“…Cardiac myofibroblasts play an important role in myocardial remodeling. Although α-smooth muscle actin (α-SMA) expression is the hallmark of mature…”
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Current advances in ischemic stroke research and therapies by Barthels, Derek, Das, Hiranmoy

“…With more than 795,000 cases occurring every year, stroke has become a major problem in the United States across all demographics. Stroke is the leading cause…”
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Serine prevented high-fat diet-induced oxidative stress by activating AMPK and epigenetically modulating the expression of glutathione synthesis-related genes by Zhou, Xihong, He, Liuqin, Zuo, Shengnan, Zhang, Yumei, Wan, Dan, Long, Ciming, Huang, Pan, Wu, Xin, Wu, Canrong, Liu, Gang, Yin, Yulong

“…Serine deficiency has been observed in patients with nonalcoholic fatty liver disease (NAFLD). Whether serine supplementation has any beneficial effects on the…”
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Neuroprotective action of resveratrol by Bastianetto, Stéphane, Ménard, Caroline, Quirion, Rémi

“…Low-to-moderate red wine consumption appeared to reduce age-related neurological disorders including macular degeneration, stroke, and cognitive deficits with…”
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Aging across the tree of life: The importance of a comparative perspective for the use of animal models in aging by Cohen, Alan A.

“…Use of model organisms in aging research is problematic because our ability to extrapolate across the tree of life is not clear. On one hand, there are…”
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Endothelial cell senescence in aging-related vascular dysfunction by Jia, Guanghong, Aroor, Annayya R., Jia, Cassie, Sowers, James R.

“…Increased cardiovascular disease in aging is partly a consequence of the vascular endothelial cell (EC) senescence and associated vascular dysfunction. In this…”
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Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs by Scheffer, Débora da Luz, Latini, Alexandra

“…A wide array of molecular pathways has been investigated during the past decade in order to understand the mechanisms by which the practice of physical…”
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Oxidative stress: Normal pregnancy versus preeclampsia by Chiarello, Delia I., Abad, Cilia, Rojas, Deliana, Toledo, Fernando, Vázquez, Carmen M., Mate, Alfonso, Sobrevia, Luis, Marín, Reinaldo

“…The role of oxidative stress in the physiopathology of human pregnancy is of particular interest. Pregnancy is well-known to increase the oxidative stress,…”
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TOP2A induces malignant character of pancreatic cancer through activating β-catenin signaling pathway by Pei, Yao-fei, Yin, Xi-min, Liu, Xi-qiang

“…It has been reported that Topoisomerase II alpha (TOP2A) could induce tumor development and progression in many cancer types. Herein, through analysis of…”
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Mitochondrial dysfunction in metabolic syndrome by Prasun, Pankaj

“…Metabolic syndrome is co-occurrence of obesity, insulin resistance, atherogenic dyslipidemia (high triglyceride, low high density lipoprotein cholesterol), and…”
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The role of the autophagy in myocardial ischemia/reperfusion injury by Ma, Sai, Wang, Yabin, Chen, Yundai, Cao, Feng

“…Autophagy is an intracellular process responsible for damaged or unnecessary protein and organelle degradation. In the heart, autophagy occurs at basal level…”
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Vascular wall extracellular matrix proteins and vascular diseases by Xu, Junyan, Shi, Guo-Ping

“…Extracellular matrix proteins form the basic structure of blood vessels. Along with providing basic structural support to blood vessels, matrix proteins…”
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PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation by Varga, Tamas, Czimmerer, Zsolt, Nagy, Laszlo

“…Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were thought to serve as simple energy storing molecules. More…”
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Oxidative stress and pulmonary fibrosis by Cheresh, Paul, Kim, Seok-Jo, Tulasiram, Sandhya, Kamp, David W.

“…Oxidative stress is implicated as an important molecular mechanism underlying fibrosis in a variety of organs, including the lungs. However, the causal role of…”
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Mast cells and inflammation by Theoharides, Theoharis C., Alysandratos, Konstantinos-Dionysios, Angelidou, Asimenia, Delivanis, Danae-Anastasia, Sismanopoulos, Nikolaos, Zhang, Bodi, Asadi, Shahrzad, Vasiadi, Magdalini, Weng, Zuyi, Miniati, Alexandra, Kalogeromitros, Dimitrios

“…Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their involvement in acquired and innate immunity. Increasing…”
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Mitophagy and mitochondrial integrity in cardiac ischemia-reperfusion injury by Yang, Mingjie, Linn, Becky S., Zhang, Yingmei, Ren, Jun

“…Ischemia-reperfusion injury (IR injury), produced by initial interruption and subsequent restoration of organ blood flow, is an important clinical dilemma…”
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Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations by Cariello, Marica, Piccinin, Elena, Garcia-Irigoyen, Oihane, Sabbà, Carlo, Moschetta, Antonio

“…The nuclear receptor farnesoid X receptor (FXR) is the master regulator of bile acids (BAs) homeostasis since it transcriptionally drives modulation of BA…”
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KIF14 promotes tumor progression and metastasis and is an independent predictor of poor prognosis in human gastric cancer by Yang, Zhongyin, Li, Chen, Yan, Chao, Li, Jianfang, Yan, Min, Liu, Bingya, Zhu, Zhenggang, Wu, Yingli, Gu, Qinlong

“…The kinesin family member 14 (KIF14) is a potential oncogene and is involved in the metastasis of various cancers. Nevertheless, its function in gastric cancer…”
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Cytokine mediated tissue fibrosis by Borthwick, Lee A., Wynn, Thomas A., Fisher, Andrew J.

“…Acute inflammation is a recognised part of normal wound healing. However, when inflammation fails to resolve and a chronic inflammatory response is established…”
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