Search Results - "Biochemistry (Easton)"

P‑Bodies: Composition, Properties, and Functions by Luo, Yang, Na, Zhenkun, Slavoff, Sarah A

“…Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to…”
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Theories for Sequence-Dependent Phase Behaviors of Biomolecular Condensates by Lin, Yi-Hsuan, Forman-Kay, Julie D, Chan, Hue Sun

“…Liquid–liquid phase separation and related condensation processes of intrinsically disordered proteins (IDPs), proteins with intrinsically disordered regions,…”
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The EFI Web Resource for Genomic Enzymology Tools: Leveraging Protein, Genome, and Metagenome Databases to Discover Novel Enzymes and Metabolic Pathways by Zallot, Rémi, Oberg, Nils, Gerlt, John A

“…The assignment of functions to uncharacterized proteins discovered in genome projects requires easily accessible tools and computational resources for…”
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Modulating α-Synuclein Liquid-Liquid Phase Separation by Sawner, Ajay Singh, Ray, Soumik, Yadav, Preeti, Mukherjee, Semanti, Panigrahi, Rajlaxmi, Poudyal, Manisha, Patel, Komal, Ghosh, Dhiman, Kummerant, Eric, Kumar, Ashutosh, Riek, Roland, Maji, Samir K

“…Liquid-liquid phase separation (LLPS) is a crucial phenomenon for the formation of functional membraneless organelles. However, LLPS is also responsible for…”
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Stabilizing Leaf and Branch Compost Cutinase (LCC) with Glycosylation: Mechanism and Effect on PET Hydrolysis by Shirke, Abhijit N, White, Christine, Englaender, Jacob A, Zwarycz, Allison, Butterfoss, Glenn L, Linhardt, Robert J, Gross, Richard A

“…Cutinases are polyester hydrolases that show a remarkable capability to hydrolyze polyethylene terephthalate (PET) to its monomeric units. This revelation has…”
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Mo-, V-, and Fe-Nitrogenases Use a Universal Eight-Electron Reductive-Elimination Mechanism To Achieve N 2 Reduction by Harris, Derek F, Lukoyanov, Dmitriy A, Kallas, Hayden, Trncik, Christian, Yang, Zhi-Yong, Compton, Phil, Kelleher, Neil, Einsle, Oliver, Dean, Dennis R, Hoffman, Brian M, Seefeldt, Lance C

“…Three genetically distinct, but structurally similar, isozymes of nitrogenase catalyze biological N reduction to 2NH : Mo-, V-, and Fe-nitrogenase, named…”
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Crystal Structure of Agaricus bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone by Ismaya, Wangsa T, Rozeboom, Henriëtte J, Weijn, Amrah, Mes, Jurriaan J, Fusetti, Fabrizia, Wichers, Harry J, Dijkstra, Bauke W

“…Tyrosinase catalyzes the conversion of phenolic compounds into their quinone derivatives, which are precursors for the formation of melanin, a ubiquitous…”
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Why Are Lopinavir and Ritonavir Effective against the Newly Emerged Coronavirus 2019? Atomistic Insights into the Inhibitory Mechanisms by Nutho, Bodee, Mahalapbutr, Panupong, Hengphasatporn, Kowit, Pattaranggoon, Nawanwat Chainuwong, Simanon, Nattapon, Shigeta, Yasuteru, Hannongbua, Supot, Rungrotmongkol, Thanyada

“…Since the emergence of a novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported…”
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Residue-Specific Peptide Modification: A Chemist’s Guide by deGruyter, Justine N, Malins, Lara R, Baran, Phil S

“…Advances in bioconjugation and native protein modification are appearing at a blistering pace, making it increasingly time consuming for practitioners to…”
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Targeting the C481S Ibrutinib-Resistance Mutation in Bruton’s Tyrosine Kinase Using PROTAC-Mediated Degradation by Buhimschi, Alexandru D, Armstrong, Haley A, Toure, Momar, Jaime-Figueroa, Saul, Chen, Timothy L, Lehman, Amy M, Woyach, Jennifer A, Johnson, Amy J, Byrd, John C, Crews, Craig M

“…Inhibition of Bruton’s tyrosine kinase (BTK) with the irreversible inhibitor ibrutinib has emerged as a transformative treatment option for patients with…”
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Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation by Garrido Ruiz, Diego, Sandoval-Perez, Angelica, Rangarajan, Amith Vikram, Gunderson, Emma L., Jacobson, Matthew P.

“…Cysteine side chains can exist in distinct oxidation states depending on the pH and redox potential of the environment, and cysteine oxidation plays important…”
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Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity by Olson, David E

“…In addition to producing profound subjective effects following acute administration, psychedelic compounds can induce beneficial behavioral changes relevant to…”
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Comparative Perturbation-Based Modeling of the SARS-CoV‑2 Spike Protein Binding with Host Receptor and Neutralizing Antibodies: Structurally Adaptable Allosteric Communication Hotspots Define Spike Sites Targeted by Global Circulating Mutations by Verkhivker, Gennady M, Agajanian, Steve, Oztas, Deniz Yazar, Gupta, Grace

“…In this study, we used an integrative computational approach to examine molecular mechanisms and determine functional signatures underlying the role of…”
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Mechanism of Quinolone Action and Resistance by Aldred, Katie J, Kerns, Robert J, Osheroff, Neil

“…Quinolones are one of the most commonly prescribed classes of antibacterials in the world and are used to treat a variety of bacterial infections in humans…”
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Monomeric Aβ(1-40) and Aβ(1-42) Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil by Roche, Julien, Shen, Yang, Lee, Jung Ho, Ying, Jinfa, Bax, Ad

“…The pathogenesis of Alzheimer's disease is characterized by the aggregation and fibrillation of amyloid peptides Aβ(1-40) and Aβ(1-42) into amyloid plaques…”
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Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions by Martin, Erik W, Mittag, Tanja

“…Liquid–liquid phase separation seems to play critical roles in the compartmentalization of cells through the formation of biomolecular condensates. Many…”
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New Electrophiles and Strategies for Mechanism-Based and Targeted Covalent Inhibitor Design by Ray, Sneha, Murkin, Andrew S

“…Covalent inhibitors are experiencing a growing resurgence in drug design and are an increasingly useful tool in molecular biology. The ability to attach…”
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Site-Specific Steric Control of SARS-CoV‑2 Spike Glycosylation by Allen, Joel D, Chawla, Himanshi, Samsudin, Firdaus, Zuzic, Lorena, Shivgan, Aishwary Tukaram, Watanabe, Yasunori, He, Wan-ting, Callaghan, Sean, Song, Ge, Yong, Peter, Brouwer, Philip J. M, Song, Yutong, Cai, Yongfei, Duyvesteyn, Helen M. E, Malinauskas, Tomas, Kint, Joeri, Pino, Paco, Wurm, Maria J, Frank, Martin, Chen, Bing, Stuart, David I, Sanders, Rogier W, Andrabi, Raiees, Burton, Dennis R, Li, Sai, Bond, Peter J, Crispin, Max

“…A central tenet in the design of vaccines is the display of native-like antigens in the elicitation of protective immunity. The abundance of N-linked glycans…”
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Emerging Approaches to Functionalizing Cell Membrane-Coated Nanoparticles by Ai, Xiangzhao, Wang, Shuyan, Duan, Yaou, Zhang, Qiangzhe, Chen, Maggie S, Gao, Weiwei, Zhang, Liangfang

“…There has been significant interest in developing cell membrane-coated nanoparticles due to their unique abilities of biomimicry and biointerfacing. As the…”
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O 2 Activation by Non-Heme Iron Enzymes by Solomon, Edward I, Goudarzi, Serra, Sutherlin, Kyle D

“…The non-heme Fe enzymes are ubiquitous in nature and perform a wide range of functions involving O activation. These had been difficult to study relative to…”
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