Search Results - "Biochemical journal"

New tools for automated cryo-EM single-particle analysis in RELION-4.0 by Kimanius, Dari, Dong, Liyi, Sharov, Grigory, Nakane, Takanori, Scheres, Sjors H W

“…We describe new tools for the processing of electron cryo-microscopy (cryo-EM) images in the fourth major release of the RELION software. In particular, we…”
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Introduction to the human gut microbiota by Thursby, Elizabeth, Juge, Nathalie

“…The human gastrointestinal (GI) tract harbours a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the…”
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New photosensitizers for photodynamic therapy by Abrahamse, Heidi, Hamblin, Michael R

“…Photodynamic therapy (PDT) was discovered more than 100 years ago, and has since become a well-studied therapy for cancer and various non-malignant diseases…”
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Molecular mechanisms of ROS production and oxidative stress in diabetes by Newsholme, Philip, Cruzat, Vinicius Fernandes, Keane, Kevin Noel, Carlessi, Rodrigo, de Bittencourt, Jr, Paulo Ivo Homem

“…Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an…”
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Structure and function of carbonic anhydrases by Supuran, Claudiu T

“…Carbonic anhydrases (CAs, EC 4.2.1.1) catalyse the interconversion between CO2 and bicarbonate as well as other hydrolytic reactions. Among the six genetic…”
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Topoisomerases as anticancer targets by Delgado, Justine L, Hsieh, Chao-Ming, Chan, Nei-Li, Hiasa, Hiroshi

“…Many cancer type-specific anticancer agents have been developed and significant advances have been made toward precision medicine in cancer treatment. However,…”
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Protein oxidation and peroxidation by Davies, Michael J

“…Proteins are major targets for radicals and two-electron oxidants in biological systems due to their abundance and high rate constants for reaction. With…”
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A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications by Kell, Douglas B, Laubscher, Gert Jacobus, Pretorius, Etheresia

“…Post-acute sequelae of COVID (PASC), usually referred to as 'Long COVID' (a phenotype of COVID-19), is a relatively frequent consequence of SARS-CoV-2…”
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Amino acid homeostasis and signalling in mammalian cells and organisms by Bröer, Stefan, Bröer, Angelika

“…Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss is mainly due to amino acid oxidation. Homeostasis is achieved…”
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The concept of intrinsic versus extrinsic apoptosis by Lossi, Laura

“…Regulated cell death is a vital and dynamic process in multicellular organisms that maintains tissue homeostasis and eliminates potentially dangerous cells…”
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Interactions between plants and soil shaping the root microbiome under abiotic stress by Hartman, Kyle, Tringe, Susannah G

“…Plants growing in soil develop close associations with soil microorganisms, which inhabit the areas around, on, and inside their roots. These microbial…”
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RNA-binding proteins with prion-like domains in health and disease by Harrison, Alice Ford, Shorter, James

“…Approximately 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD). PrLDs are low-complexity domains that possess a similar amino acid…”
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Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids by Dickson, Eamonn J, Hille, Bertil

“…Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small…”
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Therapeutic targeting of non-coding RNAs in cancer by Slaby, Ondrej, Laga, Richard, Sedlacek, Ondrej

“…The majority of the human genome encodes RNAs that do not code for proteins. These non-coding RNAs (ncRNAs) affect normal expression of the genes, including…”
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Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria by Bridges, Hannah R, Jones, Andrew J Y, Pollak, Michael N, Hirst, Judy

“…The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite evidence that inhibition of…”
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Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics by Yang, Alexander, Mottillo, Emilio P

“…Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD) organelles by professional storage cells called adipocytes…”
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An essential role for functional lysosomes in ferroptosis of cancer cells by Torii, Seiji, Shintoku, Ryosuke, Kubota, Chisato, Yaegashi, Makoto, Torii, Ryoko, Sasaki, Masaya, Suzuki, Toshinobu, Mori, Masanobu, Yoshimoto, Yuhei, Takeuchi, Toshiyuki, Yamada, Keiichi

“…Pharmacological challenges to oncogenic Ras-expressing cancer cells have shown a novel type of cell death, ferroptosis, which requires intracellular iron. In…”
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Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis by Liu, Yubao, Zou, Rui, Wang, Zhen, Wen, Chuanyang, Zhang, Fan, Lin, Fuqing

“…The present study was designed to explore whether exosomal lncRNA-KLF3-AS1 derived from human mesenchymal stem cells (hMSCs) can serve as a positive treatment…”
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Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling by Lee, Jisun, Giordano, Samantha, Zhang, Jianhua

“…Reactive oxygen and nitrogen species change cellular responses through diverse mechanisms that are now being defined. At low levels, they are signalling…”
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The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human by Mir, Rafeeq, Tonelli, Francesca, Lis, Pawel, Macartney, Thomas, Polinski, Nicole K, Martinez, Terina N, Chou, Meng-Yun, Howden, Andrew J M, König, Theresa, Hotzy, Christoph, Milenkovic, Ivan, Brücke, Thomas, Zimprich, Alexander, Sammler, Esther, Alessi, Dario R

“…Missense mutations in the LRRK2 (Leucine-rich repeat protein kinase-2) and VPS35 genes result in autosomal dominant Parkinson's disease. The VPS35 gene encodes…”
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