Search Results - "Biochemical Society transactions"

Omega-3 fatty acids and inflammatory processes: from molecules to man by Calder, Philip C

“…Inappropriate, excessive or uncontrolled inflammation contributes to a range of human diseases. Inflammation involves a multitude of cell types, chemical…”
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Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways by Wardyn, Joanna D, Ponsford, Amy H, Sanderson, Christopher M

“…In most tissues, cells are exposed to frequent changes in levels of oxidative stress and inflammation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and…”
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MSC exosome works through a protein-based mechanism of action by Toh, Wei Seong, Lai, Ruenn Chai, Zhang, Bin, Lim, Sai Kiang

“…Mesenchymal stem cell (MSC) exosome specifically defines the 50-200 nm vesicles that are secreted into the extracellular space when multivesicular bodies in…”
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Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis by Erdogan, Begum, Webb, Donna J

“…Cancer-associated fibroblasts (CAFs) are major components of the surrounding stroma of carcinomas that emerge in the tumor microenvironment as a result of…”
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The Warburg effect: 80 years on by Potter, Michelle, Newport, Emma, Morten, Karl J

“…Influential research by Warburg and Cori in the 1920s ignited interest in how cancer cells' energy generation is different from that of normal cells. They…”
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The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease by Babu, M Madan

“…In the 1960s, Christian Anfinsen postulated that the unique three-dimensional structure of a protein is determined by its amino acid sequence. This work laid…”
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LRRK2 links genetic and sporadic Parkinson's disease by Kluss, Jillian H, Mamais, Adamantios, Cookson, Mark R

“…The past two decades in research has revealed the importance of leucine-rich repeat kinase 2 (LRRK2) in both monogenic and sporadic forms of Parkinson's…”
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Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically? by Macdonald, Ruby, Barnes, Katy, Hastings, Christopher, Mortiboys, Heather

“…Mitochondrial abnormalities have been identified as a central mechanism in multiple neurodegenerative diseases and, therefore, the mitochondria have been…”
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Structure and function of the cytochrome P450 peroxygenase enzymes by Munro, Andrew W, McLean, Kirsty J, Grant, Job L, Makris, Thomas M

“…The cytochromes P450 (P450s or CYPs) constitute a large heme enzyme superfamily, members of which catalyze the oxidative transformation of a wide range of…”
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LRRK2 regulation of immune-pathways and inflammatory disease by Wallings, Rebecca L, Tansey, Malú G

“…Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene are associated with familial and sporadic cases of Parkinson's disease but are also found in…”
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Targeted therapy and drug resistance in triple-negative breast cancer: the EGFR axis by Lev, Sima

“…Targeting of estrogen receptor is commonly used as a first-line treatment for hormone-positive breast cancer patients, and is considered as a keystone of…”
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Mitochondrial fission and fusion by Lee, Hakjoo, Yoon, Yisang

“…Mitochondrial fission and fusion have been recognized as critical processes in the health of mitochondria and cells. Two decades of studies have generated a…”
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The ATP synthase: the understood, the uncertain and the unknown by Walker, John E

“…The ATP synthases are multiprotein complexes found in the energy-transducing membranes of bacteria, chloroplasts and mitochondria. They employ a transmembrane…”
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ERK1/2 in immune signalling by Lucas, Richard M, Luo, Lin, Stow, Jennifer L

“…Extracellular signal-related kinases 1 and 2 (ERK1/2) are the final components of the mitogen-activated protein kinase (MAPK) phosphorylation cascade, an…”
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ABC transporter research: going strong 40 years on by Theodoulou, Frederica L, Kerr, Ian D

“…In most organisms, ABC transporters constitute one of the largest families of membrane proteins. In humans, their functions are diverse and underpin numerous…”
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Mammalian DNA methyltransferases: new discoveries and open questions by Gowher, Humaira, Jeltsch, Albert

“…As part of the epigenetic network, DNA methylation is a major regulator of chromatin structure and function. In mammals, it mainly occurs at palindromic CpG…”
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MicroRNA-based therapeutics in cardiovascular disease: screening and delivery to the target by Mellis, David, Caporali, Andrea

“…MicroRNAs (miRNAs) are small non-coding RNAs of ∼22 nucleotides, which have increasingly been recognized as potent post-transcriptional regulators of gene…”
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Rho family GTPases by Hall, Alan

“…Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding…”
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G-quadruplex unwinding helicases and their function in vivo by Sauer, Markus, Paeschke, Katrin

“…The concept that G-quadruplex (G4) structures can form within DNA or RNA has been long known and extensively discussed. In recent years, accumulating evidences…”
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Biomarkers of inflammation and the etiology of sepsis by Grondman, Inge, Pirvu, Andrei, Riza, Anca, Ioana, Mihai, Netea, Mihai G

“…Sepsis is characterized as a life-threatening organ dysfunction syndrome that is caused by a dysregulated host response to infection. The main etiological…”
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