Search Results - "Bio, Matthew M"

Ni-Catalyzed Electrochemical Decarboxylative C–C Couplings in Batch and Continuous Flow by Li, Hui, Breen, Christopher P, Seo, Hyowon, Jamison, Timothy F, Fang, Yuan-Qing, Bio, Matthew M

“…An electrochemically driven, nickel-catalyzed reductive coupling of N-hydroxyphthalimide esters with aryl halides is reported. The reaction proceeds under mild…”
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Rh(III)-Catalyzed C–H Activation and Double Directing Group Strategy for the Regioselective Synthesis of Naphthyridinones by Huckins, John R, Bercot, Eric A, Thiel, Oliver R, Hwang, Tsang-Lin, Bio, Matthew M

“…A general Rh(III)-catalyzed synthesis of naphthyridinone derivatives is described. It relies on a double-activation and directing approach leveraging…”
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SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm by Hamblett, Kevin J, Jacob, Allison P, Gurgel, Jesse L, Tometsko, Mark E, Rock, Brooke M, Patel, Sonal K, Milburn, Robert R, Siu, Sophia, Ragan, Seamus P, Rock, Dan A, Borths, Christopher J, O'Neill, Jason W, Chang, Wesley S, Weidner, Margaret F, Bio, Matthew M, Quon, Kim C, Fanslow, William C

“…Antibody-drug conjugates (ADC) target cytotoxic drugs to antigen-positive cells for treating cancer. After internalization, ADCs with noncleavable linkers are…”
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Highly Regioselective Halogenation of Pyridine N‑Oxide: Practical Access to 2‑Halo-Substituted Pyridines by Chen, Ying, Huang, Jinkun, Hwang, Tsang-Lin, Chen, Maosheng J, Tedrow, Jason S, Farrell, Robert P, Bio, Matthew M, Cui, Sheng

“…A highly efficient and regioselective halogenation reaction of unsymmetrical pyridine N-oxide under mild conditions is described. The methodology provides a…”
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Synthesis of 4‑Substituted Phthalazin-1(2H)‑ones from 2‑Acylbenzoic Acids: Controlling Hydrazine in a Pharmaceutical Intermediate through PAT-Guided Process Development by Mennen, Steven M, Mak-Jurkauskas, Melody L, Bio, Matthew M, Hollis, L. Steven, Nadeau, Kelly A, Clausen, Andrew M, Hansen, Karl B

“…A simple one-pot, two-step process for the conversion of 2-acylbenzoic acids to phthalazin-1­(2H)-ones was developed. A robust process was required that…”
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Practical Access to Metallo Thiophenes: Regioselective Synthesis of 2,4-Disubstituted Thiophenes by Asselin, Sylvie M, Bio, Matthew M, Langille, Neil F, Ngai, Ka Yi

“…This report describes a protocol for functionalization of thiophenes, utilizing a regioselective magnesiation mediated by commercial Grignard reagents and…”
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An Approach to the Synthesis of the Phomoidrides by Bio, Matthew M, Leighton, James L

“…The phomoidrides are a structurally fascinating family of natural products which possess moderate inhibitory activity against Ras farnesyl transferase and…”
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Flow Asymmetric Propargylation: Development of Continuous Processes for the Preparation of a Chiral β‐Amino Alcohol by Li, Hui, Sheeran, Jillian W., Clausen, Andrew M., Fang, Yuan‐Qing, Bio, Matthew M., Bader, Scott

“…The development of a flow chemistry process for asymmetric propargylation using allene gas as a reagent is reported. The connected continuous process of allene…”
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A Continuous Flow Process for LSN647712 via Double Organometallic Additions to Dimethylcarbamyl Chloride by Li, Hui, Sheeran, Jillian W, Kouvchinov, David, Clausen, Andrew M, Crouch, Ian T, Bio, Matthew M, Fang, Yuan-Qing, Frank, Scott A, Johnson, Martin D, Kerr, Mark S

“…The ketone intermediate LSN647712 is a key synthetic intermediate for the drug substance lasmiditan manufacturing process. A three-step connected continuous…”
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Scalable On-Demand Production of Purified Diazomethane Suitable for Sensitive Catalytic Reactions by Sheeran, Jillian W, Campbell, Kiersten, Breen, Christopher P, Hummel, Gerald, Huang, Changfeng, Datta, Anamika, Boyer, Serge H, Hecker, Scott J, Bio, Matthew M, Fang, Yuan-Qing, Ford, David D, Russell, M. Grace

“…We have developed a convenient development-scale reactor (0.44 mol/h) to prepare diazomethane from N-methyl-N-nitroso-p-toluenesulfonamide (MNTS) in ∼80%…”
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Magnesium Coordination-Directed N-Selective Stereospecific Alkylation of 2-Pyridones, Carbamates, and Amides Using α-Halocarboxylic Acids by Fang, Yuan-Qing, Bio, Matthew M, Hansen, Karl B, Potter, Matthew S, Clausen, Andrew

“…A general inversion-stereospecific, N-selective alkylation of substituted 2-pyridones (and analogues), amides, and carbamates using chiral α-chloro- or…”
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Development of a Commercial Process To Prepare AMG 232 Using a Green Ozonolysis–Pinnick Tandem Transformation by Cochran, Brian M, Corbett, Michael T, Correll, Tiffany L, Fang, Yuan-Qing, Flick, Tawnya G, Jones, Siân C, Silva Elipe, Maria V, Smith, Austin G, Tucker, John L, Vounatsos, Filisaty, Wells, Greg, Yeung, David, Walker, Shawn D, Bio, Matthew M, Caille, Seb

“…A robust process to manufacture AMG 232 was developed to deliver drug substance of high purity. Highlights of the commercial process development efforts…”
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Telescoped Process to Manufacture 6,6,6-Trifluorofucose via Diastereoselective Transfer Hydrogenation: Scalable Access to an Inhibitor of Fucosylation Utilized in Monoclonal Antibody Production by Achmatowicz, Michal M, Allen, John G, Bio, Matthew M, Bartberger, Michael D, Borths, Christopher J, Colyer, John T, Crockett, Richard D, Hwang, Tsang-Lin, Koek, Jan. N, Osgood, Stephen A, Roberts, Scott W, Swietlow, Aleksander, Thiel, Oliver R, Caille, Seb

“…IgG1 monoclonal antibodies with reduced glycan fucosylation have been shown to improve antibody-dependent cellular cytotoxicity (ADCC) by allowing more…”
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Crystallization-Induced Dynamic Resolution of a Diarylmethylamine toward the Synthesis of a Potent TRPM8 Inhibitor by Beaver, Matthew G, Langille, Neil F, Cui, Sheng, Fang, Yuan-Qing, Bio, Matthew M, Potter-Racine, Matthew S, Tan, Helming, Hansen, Karl B

“…The development and demonstration of a crystallization-induced dynamic resolution (CIDR) to prepare a chiral diarylmethylamine, a key intermediate toward the…”
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Practical Syntheses of a CXCR3 Antagonist by Chan, Johann, Burke, Brenda J, Baucom, Kyle, Hansen, Karl, Bio, Matthew M, DiVirgilio, Evan, Faul, Margaret, Murry, Jerry

“…Two new, reliable syntheses of a pyrido[2,3-d]-pyrimidine inhibitor of the CXCR3 receptor are described. A nine-step synthesis of the CXCR3 inhibitor (1) from…”
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Selective protodeboronation: synthesis of 4-methyl-2-thiopheneboronic anhydride and demonstration of its utility in Suzuki–Miyaura reactions by Klingensmith, Liane M., Bio, Matthew M., Moniz, George A.

“…An efficient synthesis of 4-methyl-2-thiopheneboronic anhydride is reported. Regioselective lithiation of 3-methylthiophene followed by reaction with…”
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Process Development and Multikilogram-Scale Synthesis of a TRPV1 Antagonist by Cleator, Ed, Scott, Jeremy P, Avalle, Paulo, Bio, Matthew M, Brewer, Sarah E, Davies, Antony J, Gibb, Andrew D, Sheen, Faye J, Stewart, Gavin W, Wallace, Debra J, Wilson, Robert D

“…The process development and multikilogram preparation of a TRPV1 antagonist, 1, is described. Pyrido[2,3-b]pyrazine 1 was prepared in a convergent manner by…”
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Practical Synthesis of a Potent Hepatitis C Virus RNA Replication Inhibitor by Bio, Matthew M, Xu, Feng, Waters, Marjorie, Williams, J. Michael, Savary, Kimberly A, Cowden, Cameron J, Yang, Chunhua, Buck, Elizabeth, Song, Zhiguo J, Tschaen, David M, Volante, R. P, Reamer, Robert A, Grabowski, Edward J. J

“…A practical, efficient synthesis of 1, a hepatitis C virus RNA replication inhibitor, is described. Starting with the inexpensive diacetone glucose, the…”
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An Approach to the Synthesis of CP-263,114:  A Remarkably Facile Silyloxy-Cope Rearrangement by Bio, Matthew M, Leighton, James L

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A Practical and Scaleable Synthesis of 1R,5S-Bicyclo[3.1.0]hexan-2-one:  The Development of a Catalytic Lithium 2,2,6,6-Tetramethylpiperidide (LTMP) Mediated Intramolecular Cyclopropanation of (R)-1,2-Epoxyhex-5-ene by Alorati, Anthony D, Bio, Matthew M, Brands, Karel M. J, Cleator, Ed, Davies, Antony J, Wilson, Robert D, Wise, Chris S

“…An efficient synthesis of 1R,5S-bicyclo[3.1.0]hexan-2-one from (R)-1,2-epoxyhex-5-ene is described. Development of a catalytic intramolecular cyclopropanation…”
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