Search Results - "Binyamin, Orli"

Mitochondrial dysfunction in preclinical genetic prion disease: A target for preventive treatment? by Keller, Guy, Binyamin, Orli, Frid, Kati, Saada, Ann, Gabizon, Ruth

“…Mitochondrial malfunction is a common feature in advanced stages of neurodegenerative conditions, as is the case for the accumulation of aberrantly folded…”
Get full text

Brain targeting of 9c,11t-Conjugated Linoleic Acid, a natural calpain inhibitor, preserves memory and reduces Aβ and P25 accumulation in 5XFAD mice by Binyamin, Orli, Nitzan, Keren, Frid, Kati, Ungar, Yael, Rosenmann, Hanna, Gabizon, Ruth

“…Deregulation of Cyclin-dependent kinase 5 (CDK5) by binding to the activated calpain product p25, is associated with the onset of neurodegenerative diseases,…”
Get full text

Continues administration of Nano-PSO significantly increased survival of genetic CJD mice by Binyamin, Orli, Keller, Guy, Frid, Kati, Larush, Liraz, Magdassi, Shlomo, Gabizon, Ruth

“…We have shown previously that Nano-PSO, a nanodroplet formulation of pomegranate seed oil, delayed progression of neurodegeneration signs when administered for…”
Get full text

Author Correction: Brain targeting of 9c,11t-Conjugated Linoleic Acid, a natural calpain inhibitor, preserves memory and reduces Aβ and P25 accumulation in 5XFAD mice by Binyamin, Orli, Nitzan, Keren, Frid, Kati, Ungar, Yael, Rosenmann, Hanna, Gabizon, Ruth

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

Pomegranate seed oil nanoemulsions for the prevention and treatment of neurodegenerative diseases: the case of genetic CJD by Mizrahi, Michal, Bsc, Friedman-Levi, Yael, PhD, Larush, Liraz, PhD, Frid, Kati, Bsc, Binyamin, Orli, MSc, Dori, Dvir, MD, Fainstein, Nina, PhD, Ovadia, Haim, PhD, Ben-Hur, Tamir, Md, PhD, Magdassi, Shlomo, PhD, Gabizon, Ruth, PhD

“…Abstract Neurodegenerative diseases generate the accumulation of specific misfolded proteins, such as PrPSc prions or A-beta in Alzheimer's diseases, and share…”
Get full text

PrP(ST), a soluble, protease resistant and truncated PrP form features in the pathogenesis of a genetic prion disease by Friedman-Levi, Yael, Mizrahi, Michal, Frid, Kati, Binyamin, Orli, Gabizon, Ruth

“…While the conversion of PrP(C) into PrP(Sc) in the transmissible form of prion disease requires a preexisting PrP(Sc) seed, in genetic prion disease…”
Get full text

PrPST, a Soluble, Protease Resistant and Truncated PrP Form Features in the Pathogenesis of a Genetic Prion Disease by Friedman-Levi, Yael, Mizrahi, Michal, Frid, Kati, Binyamin, Orli, Gabizon, Ruth

“…While the conversion of PrPC into PrPSc in the transmissible form of prion disease requires a preexisting PrPSc seed, in genetic prion disease accumulation of…”
Get full text

Correction: PrPST, a Soluble, Protease Resistant and Truncated PrP Form Features in the Pathogenesis of a Genetic Prion Disease by Friedman-Levi, Yael, Mizrahi, Michal, Frid, Kati, Binyamin, Orli, Gabizon, Ruth

Get full text

Copper is toxic to PrP-ablated mice and exacerbates disease in a mouse model of E200K genetic prion disease by Canello, Tamar, Friedman-Levi, Yael, Mizrahi, Michal, Binyamin, Orli, Cohen, Eran, Frid, Kati, Gabizon, Ruth

“…Abstract The pathogenesis of the diverse forms of prion disease was attributed solely to the accumulation of the misfolded PrP forms, and not to the potential…”
Get full text

Aggregation of MBP in chronic demyelination by Frid, Kati, Einstein, Ofira, Friedman‐Levi, Yael, Binyamin, Orli, Ben‐Hur, Tamir, Gabizon, Ruth

“…Objectives Misfolding of key disease proteins to an insoluble state is associated with most neurodegenerative conditions, such as prion, Parkinson, and…”
Get full text

Comparing anti–aging hallmark activities of Metformin and Nano-PSO in a mouse model of genetic Creutzfeldt-Jakob Disease by Binyamin, Orli, Frid, Kati, Keller, Guy, Saada, Ann, Gabizon, Ruth

“…•We tested aging hallmarks levels in CJD mice treated with Metformin or Nano-PSO.•Both reagents reduced aging hallmarks activities in a similar way.•Only…”
Get full text

Delay of gCJD aggravation in sick TgMHu2ME199K mice by combining NPC transplantation and Nano-PSO administration by Frid, Kati, Binyamin, Orli, Usman, Areen, Gabizon, Ruth

“…gCJD is a fatal late-onset neurodegenerative disease linked to mutations in the PRNP gene. We have previously shown that transplantation of neural precursor…”
Get full text

Granagard administration prolongs the survival of human mesenchymal stem cells transplanted into a mouse model of multiple sclerosis by Frid, Kati, Usmann, Areen, Markovits-Pachter, Tsipora, Binyamin, Orli, Petrou, Panayota, Kassis, Ibrahim, Karussis, Dimitri, Gabizon, Ruth

“…The clinical effect of human Mesenchymal stem cells (hMSCs) transplanted into EAE mice/MS patients is short lived due to poor survival of the transplanted…”
Get full text

Beneficial effects of a nano formulation of pomegranate seed oil, GranaGard, on the cognitive function of multiple sclerosis patients by Petrou, Panayiota, Ginzberg, Ariel, Binyamin, Orli, Karussis, Dimitrios

“…•No adverse events were recorded during a 3-month treatment of patients with MS with GranaGard, a brain targeting nano-formulation of PSO.•GranaGard…”
Get full text

Genetic prion disease: no role for the immune system in disease pathogenesis? by Friedman-Levi, Yael, Binyamin, Orli, Frid, Kati, Ovadia, Haim, Gabizon, Ruth

Get full text

Corrigendum to: Genetic prion disease: no role for the immune system in disease pathogenesis? by Friedman-Levi, Yael, Binyamin, Orli, Frid, Kati, Ovadia, Haim, Gabizon, Ruth

Get full text

Autologous neural progenitor cell transplantation into newborn mice modeling for E200K genetic prion disease delays disease progression by Frid, Kati, Binyamin, Orli, Fainstein, Nina, Keller, Guy, Ben-Hur, Tamir, Gabizon, Ruth

“…TgMHu2ME199K mice, a transgenic line mimicking genetic prion disease, are born healthy and gradually deteriorate to a terminal neurological condition…”
Get full text

QKI-V5 is downregulated in CNS inflammatory demyelinating diseases by Lavon, Iris, leykin, Ina, Charbit, Hanna, Binyamin, Orli, Brill, Livnat, Ovadia, Haim, Vaknin-Dembinsky, Adi

“…•QKI gene encodes a RNA-binding-protein that plays a central role in myelination.•Expression of QKI-V5 is decreased in the blood of NMO and MS patients.•Sera…”
Get full text

Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant by Binyamin, Orli, Larush, Liraz, Frid, Kati, Keller, Guy, Friedman-Levi, Yael, Ovadia, Haim, Abramsky, Oded, Magdassi, Shlomo, Gabizon, Ruth

“…Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and is associated with demyelination, neurodegeneration, and…”
Get full text

Correction: PrP.sup.ST, a Soluble, Protease Resistant and Truncated PrP Form Features in the Pathogenesis of a Genetic Prion Disease by Friedman-Levi, Yael, Mizrahi, Michal, Frid, Kati, Binyamin, Orli, Gabizon, Ruth

Get full text