Search Results - "Binoux, Michel"

A Targeted Partial Invalidation of the Insulin-Like Growth Factor I Receptor Gene in Mice Causes a Postnatal Growth Deficit by Holzenberger, Martin, Leneuve, Patricia, Hamard, Ghislaine, Ducos, Bertrand, Perin, Laurence, Binoux, Michel, Le Bouc, Yves

“…Abstract The insulin-like growth factor (IGF) system is a major regulator of somatic growth in vertebrates. Both ligands (IGF-I and IGF-II) signal via the same…”
Get full text

Evidence of enzymatic degradation of insulin-like growth factor-binding proteins in the 150K complex during pregnancy by Hossenlopp, P, Segovia, B, Lassarre, C, Roghani, M, Bredon, M, Binoux, M

“…Western ligand blot analysis of the different molecular forms of insulin-like growth factor-binding protein IGF-BP) in serum and plasma samples from 89…”
Get more information

Insulin-like Growth Factor-binding Protein-3 Activates a Phosphotyrosine Phosphatase by Ricort, Jean-Marc, Binoux, Michel

“…The proliferative action of insulin-like growth factors (IGF-I and -II) is mediated via the type I IGF receptor (IGF-IR) and is modulated by their association…”
Get full text

Insulin-like growth factor (IGF) and IGF-binding proteins: comparison of human serum and lymph by Binoux, M, Hossenlopp, P

“…The extent to which the association between insulin-like growth factors (IGFs) and their specific binding proteins (BPs) prevents their crossing the capillary…”
Get more information

Analysis of serum insulin-like growth factor binding proteins using western blotting: use of the method for titration of the binding proteins and competitive binding studies by Hossenlopp, P, Seurin, D, Segovia-Quinson, B, Hardouin, S, Binoux, M

“…A nitrocellulose gel transfer technique has been adapted to study the insulin-like growth factor (IGF) binding proteins of human serum. Normal and…”
Get more information

Serum levels of insulin-like growth factor (IGF) and IGF binding protein in insulin-dependent diabetics during an episode of severe metabolic decompensation and the recovery phase by Rieu, M, Binoux, M

“…Serum insulin-like growth factor (IGF) and IGF-binding protein (IGF BP) levels were determined in 13 insulin-dependent diabetic patients (30-60 yr of age)…”
Get more information

Tools Now Exist to Measure Circulating IGF-Binding Protein-3 Proteolysis, to Study Its Regulation and Its Effects on IGF-I Bioavailability by Binoux, Michel

Get full text

Insulin-Like Growth Factor Binding Protein (IGFBP-1) Involvement in Intrauterine Growth Retardation: Study on IGFBP-1 Overexpressing Transgenic Mice by Ben Lagha, Nadia, Seurin, Danielle, Le Bouc, Yves, Binoux, Michel, Berdal, Ariane, Menuelle, Pierrette, Babajko, Sylvie

“…In humans, intrauterine growth retardation is correlated to high levels of serum IGF binding protein-1 (IGFBP-1). This present study analyzes in vivo the…”
Get full text

Insulin-Like Growth Factor (IGF) Binding Protein-3 Interacts with the Type 1 IGF Receptor, Reducing the Affinity of the Receptor for its Ligand: An Alternative Mechanism in the Regulation of IGF Action by Mohseni-Zadeh, Sarah, Binoux, Michel

“…With a view to determining the mechanisms by which insulin-like growth factor binding protein-3 (IGFBP-3) and its proteolytic fragments modulate IGF action, we…”
Get full text

Insulin-like growth factor-binding protein-3 activates a phosphotyrosine phosphatase. Effects on the insulin-like growth factor signaling pathway by Ricort, Jean-Marc, Binoux, Michel

“…The proliferative action of insulin-like growth factors (IGF-I and -II) is mediated via the type I IGF receptor (IGF-IR) and is modulated by their association…”
Get full text

A proteolytic fragment of insulin-like growth factor (IGF) binding protein-3 that fails to bind IGFs inhibits the mitogenic effects of IGF-I and insulin by Lalou, C, Lassarre, C, Binoux, M

“…Limited proteolysis of insulin-like growth factor binding protein-3 (IGFBP-3) is increasingly becoming recognized as an essential mechanism in the regulation…”
Get full text

Liver-Specific Expression of Human Insulin-Like Growth Factor Binding Protein-1 in Transgenic Mice: Repercussions on Reproduction, Ante- and Perinatal Mortality and Postnatal Growth by Gay, Emmanuel, Seurin, Danielle, Babajko, Sylvie, Doublier, Sophie, Cazillis, Michéle, Binoux, Michel

“…Abstract Study of the in vivo functions of the insulin-like growth factor binding proteins (IGFBPs) is complicated by their variety (six molecular species) and…”
Get full text

In vivo proteolysis of serum insulin-like growth factor (IGF) binding protein-3 results in increased availability of IGF to target cells by BLAT, C, VILLAUDY, J, BINOUX, M

“…IGF Binding Protein-3 (IGFBP-3), the major IGF carrier in the blood, undergoes limited proteolysis which reduces its affinity for IGFs, thus facilitating…”
Get full text

Measurement of Intact Insulin-Like Growth Factor-Binding Protein-3 in Human Plasma Using a Ligand Immunofunctional Assay 1 by LASSARRE, CLAUDINE, BINOUX, MICHEL

Get full text

Measurement of Intact Insulin-Like Growth Factor-Binding Protein-3 in Human Plasma Using a Ligand Immunofunctional Assay1 by LASSARRE, CLAUDINE, BINOUX, MICHEL

“…Limited proteolysis of insulin-like growth factor binding protein-3 (IGFBP-3) is a fundamental mechanism in the regulation of IGF-I bioavailability in the…”
Get full text

Insulin-like growth factor binding protein-3 is functionally altered in pregnancy plasma by Lassarre, C, Binoux, M

“…In a variety of physio-pathological conditions, but also in the normal state, calcium-dependent serine protease(s) partially proteolyze proportions of…”
Get more information

The 16-kDa proteolytic fragment of insulin-like growth factor (IGF) binding protein-3 inhibits the mitogenic action of fibroblast growth factor on mouse fibroblasts with a targeted disruption of the type 1 IGF receptor gene by Zadeh, S M, Binoux, M

“…We previously reported that a 16-kDa proteolytic fragment of IGF Binding Protein-3 (IGFBP-3), which is devoid of affinity for IGFs, inhibits the mitogenic…”
Get full text

Insulin-Like Growth Factor (IGF) Binding Protein-3 Inhibits Type 1 IGF Receptor Activation Independently of Its IGF Binding Affinity1 by Ricort, Jean-Marc, Binoux, Michel

“…Insulin-like growth factor binding proteins (IGFBPs) regulate the cellular actions of the IGFs owing to their strong affinities, which are equal to or stronger…”
Get full text

Insulin-Like Growth Factor (IGF) Binding Protein-3 Inhibits Type 1 IGF Receptor Activation Independently of Its IGF Binding AffinityThis work was supported by the Institut National de la Santé et de la Recherche Médicale and the University of Paris VI by Ricort, Jean-Marc, Binoux, Michel

Get full text

Insulin-like growth factor binding protein-3 stimulates phosphatidylinositol 3-kinase in MCF-7 breast carcinoma cells by Ricort, Jean-Marc, Binoux, Michel

“…Insulin-like growth factor binding protein-3 (IGFBP-3) is the most abundant IGFBP in serum and other biological fluids. Apart from its capacity for specific…”
Get full text