Search Results - "Binns, Richard M."

Heterogeneity of lymphocyte homing physiology: several mechanisms operate in the control of migration to lymphoid and non-lymphoid organs in vivo by Pabst, R, Binns, R M

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Improved protocol for colorimetric detection of complement-mediated cytotoxicity based on the measurement of cytoplasmic lactate dehydrogenase activity by Sepp, Armin, Binns, Richard M., Lechler, Robert I.

“…The conventional cytotoxicity detection protocols based on the lactate dehydrogenase (LDH) activity assays rely upon the quantitation of the enzyme activity…”
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Lymphocytes migrate from the bronchoalveolar space to regional bronchial lymph nodes by Pabst, R, Binns, R M

“…The fate of lymphocytes in the bronchoalveolar tract was studied in normal young pigs. Peripheral blood lymphocytes were labeled with 51chromium or with…”
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Imaging Vascular Endothelial Activation: An Approach Using Radiolabeled Monoclonal Antibodies Against the Endothelial Cell Adhesion Molecule E-Selectin by Keelan, Edward T.M, Harrison, Andrew A, Chapman, Peter T, Binns, Richard M, Peters, A. Michael, Haskard, Dorian O

“…E-selectin is an endothelial cell-specific adhesion molecule for leukocytes expressed on the luminal surface of vascular endothelium during inflammatory…”
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Inflammatory arthritis: imaging of endothelial cell activation with an indium-111-labeled F(ab')2 fragment of anti-E-selectin monoclonal antibody by Jamar, F, Chapman, P T, Harrison, A A, Binns, R M, Haskard, D O, Peters, A M

“…To use imaging performed with an indium-111-labeled F(ab')2 fragment of monoclonal antibody that recognizes E-selectin (1.2B6) to evaluate inflammation. After…”
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The role of E-selectin in lymphocyte and polymorphonuclear cell recruitment into cutaneous delayed hypersensitivity reactions in sensitized pigs by Binns, RM, Whyte, A, Licence, ST, Harrison, AA, Tsang, YT, Haskard, DO, Robinson, MK

“…We have studied the role of E-selectin in leukocyte accumulation into Ag-specific cutaneous delayed-type hypersensitivity reactions in pigs sensitized to the…”
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In vivo E-selectin upregulation correlates early with infiltration of PMN, later with PBL entry: MAbs block both by Binns, R M, Licence, S T, Harrison, A A, Keelan, E T, Robinson, M K, Haskard, D O

“…The endothelial molecule E-selectin binds most leukocyte subsets in vitro. Yet its role in regulating the very different kinetics of inflammatory infiltration…”
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RANTES and chemokines in rheumatoid arthritis by Whyte, A, Binns, R M

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Adhesion molecule expression and infiltrating maternal leucocyte phenotypes during blastocyst implantation in the pig by Whyte, A, Binns, R M

“…During the implantation period (days 14 to 30 post coitum) in Large White pigs substantial numbers of endometrial sub-epithelial leucocytes were observed from…”
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Mechanisms for variability in a member of the scavenger-receptor cysteine-rich superfamily by Kanan, J H, Nayeem, N, Binns, R M, Chain, B M

“…This study reports a molecular analysis of pig WC1, a new member of the scavenger-receptor cysteine-rich (SRCR) superfamily. The pig WC1 contains up to six…”
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The behaviour of monoclonal antibodies in the First International Pig CD Workshop reacting with γδ/Null T lymphocytes in the blood of [formula omitted] line pigs by Licence, Stephen T., Davis, William C., Carr, Margaret M., Binns, Richard M.

“…Further studies were carried out on the monoclonal antibodies (mAbs) from the First International Swine CD Workshop which react with γδ Null T-lymphocytes,…”
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Active lymphocyte traffic induced in the periphery by cytokines and phytohemagglutinin: three different mechanisms? by Binns, R M, Licence, S T, Wooding, F B, Duffus, W P

“…Phytohemagglutinin (PHA) injection induces transient protease-sensitive traffic of lymphocytes in skin and other tissues in several species. Examination of the…”
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Analyses of monoclonal antibodies reactive with porcine CD44 and CD45 by Zuckermann, F A, Binns, R M, Husmann, R, Yang, H, Carr, M M, Kim, Y B, Davis, W C, Misfeldt, M, Lunney, J K

“…Twenty-six monoclonal antibodies (mAbs), assigned to the CD44/CD45 section of the First International Swine CD Workshop, were compared for their reactivity…”
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Clearance pathways of soluble immune complexes in the pig. Insights into the adaptive nature of antigen clearance in humans by Davies, KA, Chapman, PT, Norsworthy, PJ, Jamar, F, Athanassiou, P, Keelan, ET, Harrison, AA, Binns, RM, Haskard, DO, Walport, MJ

“…Efficient delivery of immune complexes (ICs) to the mononuclear phagocytic system, and subsequent IC processing, may prevent their potentially harmful effects…”
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Homing of blood, splenic, and lung emigrant lymphoblasts: comparison with the behaviour of lymphocytes from these sources by Binns, R M, Licence, S T, Pabst, R

“…The distinctive homing patterns of [125I]deoxyuridine-labelled lymphoblasts and 51Cr-labelled lymphocytes from the three sites--splenic and pulmonary venous…”
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Isolation and N-terminal sequence determination of a novel γ/δ T cell surface antigen by Nayeem, Naushaba, Barker, Patrick J., Binns, Richard M., Kanan, J., Chain, Benjamin

“…An antigen complex unique for porcine γ/δ T cells has previously been identified using the monoclonal antibodies MAC319 and MAC320. Here we use digestion with…”
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Exit of recirculating lymphocytes from lymph nodes is directed by specific exit signals by Binns, R M, Licence, S T

“…During recirculation, lymphocytes leave the peculiar structurally inverted lymph nodes (LN) of pigs via blood vessels instead of via efferent lymphatics, as in…”
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CD44 is involved in porcine natural cytotoxicity by Yang, H, Binns, R M

“…A polyclonal anti-porcine CD44 antibody was used to elucidate the possible role of the CD44 molecule in porcine natural cytotoxicity. It was found that the…”
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Constitutive and inflammatory lymphocyte trafficking by Binns, Richard M., Whyte, Anthony, Licence, Stephen T.

“…Here we provide a brief overview of lymphocyte trafficking with particular emphasis on the current state of knowledge in the pig. We discuss how the emphasis…”
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Biochemical analysis of molecules reactive with monoclonal antibodies specific for porcine CD45 by Zuckermann, F A, Schabacker, D, Binns, R M

“…The apparent molecular weight of molecules reactive with eight mAbs, which were identified during the First International Swine CD Workshop as putatively…”
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