Search Results - "Binns, Derk"

Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology by Cartwright, Bethany R, Binns, Derk D, Hilton, Christopher L, Han, Sungwon, Gao, Qiang, Goodman, Joel M

“…Seipin is necessary for both adipogenesis and lipid droplet (LD) organization in nonadipose tissues; however, its molecular function is incompletely…”
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The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets by Adeyo, Oludotun, Horn, Patrick J, Lee, Sungkyung, Binns, Derk D, Chandrahas, Anita, Chapman, Kent D, Goodman, Joel M

“…Lipins are phosphatidate phosphatases that generate diacylglycerol (DAG). In this study, we report that yeast lipin, Pah1p, controls the formation of cytosolic…”
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Pet10p is a yeast perilipin that stabilizes lipid droplets and promotes their assembly by Gao, Qiang, Binns, Derk D, Kinch, Lisa N, Grishin, Nick V, Ortiz, Natalie, Chen, Xiao, Goodman, Joel M

“…Pet10p is a yeast lipid droplet protein of unknown function. We show that it binds specifically to and is stabilized by droplets containing triacylglycerol…”
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Analysis of Arc/Arg3.1 Oligomerization In Vitro and in Living Cells by Barylko, Barbara, Taylor, 4th, Clinton A, Wang, Jason, Hedde, Per Niklas, Chen, Yan, Hur, Kwang-Ho, Binns, Derk D, Brautigam, Chad A, DeMartino, George N, Mueller, Joachim D, Jameson, David M, Albanesi, Joseph P

“…Arc (also known as Arg3.1) is an activity-dependent immediate early gene product enriched in neuronal dendrites. Arc plays essential roles in long-term…”
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Mimicking Protein Kinase C Phosphorylation Inhibits Arc/Arg3.1 Palmitoylation and Its Interaction with Nucleic Acids by Barylko, Barbara, Taylor, 4th, Clinton A, Wang, Jason, Earnest, Svetlana, Stippec, Steve, Binns, Derk D, Brautigam, Chad A, Jameson, David M, DeMartino, George N, Cobb, Melanie H, Albanesi, Joseph P

“…Activity-regulated cytoskeleton-associated protein (Arc) plays essential roles in diverse forms of synaptic plasticity, including long-term potentiation (LTP),…”
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lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology by Szymanski, Kimberly M, Binns, Derk, Bartz, René, Grishin, Nick V, Li, Wei-Ping, Agarwal, Anil K, Garg, Abhimanyu, Anderson, Richard G.W, Goodman, Joel M

“…Lipodystrophy is a disorder characterized by a loss of adipose tissue often accompanied by severe hypertriglyceridemia, insulin resistance, diabetes, and fatty…”
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Differential Mobility and Self-Association of Arc/Arg3.1 in the Cytoplasm and Nucleus of Living Cells by Hedde, Per Niklas, Barylko, Barbara, Binns, Derk D, Jameson, David M, Albanesi, Joseph P

“…Arc, also known as Arg3.1, is an activity-dependent immediate–early gene product that plays essential roles in memory consolidation. A pool of Arc is located…”
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Small Molecule-mediated Insulin Hypersecretion Induces Transient ER Stress Response and Loss of Beta Cell Function by Rodrigues-dos-Santos, Karina, Roy, Gitanjali, Binns, Derk D, Grzemska, Magdalena G, Barella, Luiz F, Armoo, Fiona, McCoy, Melissa K, Huynh, Andy V, Yang, Jonathan Z, Posner, Bruce A, Cobb, Melanie H, Kalwat, Michael A

“…Pancreatic islet beta cells require a fine-tuned endoplasmic reticulum (ER) stress response for normal function; abnormal ER stress contributes to diabetes…”
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Gain-of-Function Properties of a Dynamin 2 Mutant Implicated in Charcot-Marie-Tooth Disease by Tassin, Tara C, Barylko, Barbara, Hedde, Per Niklas, Chen, Yan, Binns, Derk D, James, Nicholas G, Mueller, Joachim D, Jameson, David M, Taussig, Ronald, Albanesi, Joseph P

“…Mutations in the gene encoding dynamin 2 (DNM2), a GTPase that catalyzes membrane constriction and fission, are associated with two autosomal-dominant motor…”
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Small molecule glucagon release inhibitors with activity in human islets by Kalwat, Michael A, Rodrigues-Dos-Santos, Karina, Binns, Derk D, Wei, Shuguang, Zhou, Anwu, Evans, Matthew R, Posner, Bruce A, Roth, Michael G, Cobb, Melanie H

“…Type 1 diabetes (T1D) accounts for an estimated 5% of all diabetes in the United States, afflicting over 1.25 million individuals. Maintaining long-term blood…”
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intimate collaboration between peroxisomes and lipid bodies by Binns, Derk, Januszewski, Tom, Chen, Yue, Hill, Justin, Markin, Vladislav S, Zhao, Yingming, Gilpin, Christopher, Chapman, Kent D, Anderson, Richard G.W, Goodman, Joel M

“…Although peroxisomes oxidize lipids, the metabolism of lipid bodies and peroxisomes is thought to be largely uncoupled from one another. In this study, using…”
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Palmitoylation-regulated interactions of the pseudokinase calmodulin kinase-like vesicle-associated with membranes and Arc/Arg3.1 by Barylko, Barbara, Hedde, Per Niklas, Taylor, Clinton A, Binns, Derk D, Huang, Yu-Kai, Molinaro, Gemma, Huber, Kimberly M, Jameson, David M, Albanesi, Joseph P

“…Calmodulin kinase-like vesicle-associated (CaMKv), a pseudokinase belonging to the Ca /calmodulin-dependent kinase family, is expressed predominantly in brain…”
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Membrane Remodeling by Arc/Arg3.1 by Hedde, Per Niklas, Malacrida, Leonel, Barylko, Barbara, Binns, Derk D, Albanesi, Joseph P, Jameson, David M

“…The activity-regulated cytoskeletal-associated protein (Arc, also known as Arg3.1) is an immediate early gene product induced by activity/experience and…”
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Palmitoylation Controls the Catalytic Activity and Subcellular Distribution of Phosphatidylinositol 4-Kinase IIα by Barylko, Barbara, Mao, Yuntao S., Wlodarski, Pawel, Jung, Gwanghyun, Binns, Derk D., Sun, Hui-Qiao, Yin, Helen L., Albanesi, Joseph P.

“…Phosphatidylinositol 4-kinases play essential roles in cell signaling and membrane trafficking. They are divided into type II and III families, which have…”
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α2-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling by Kalwat, Michael A., Huang, Zhimin, Binns, Derk D., McGlynn, Kathleen, Cobb, Melanie H.

“…Adrenergic signaling is a well-known input into pancreatic islet function. Specifically, the insulin-secreting islet β cell expresses the Gi/o-linked…”
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Cooperative, ATP-dependent Association of the Nucleotide Binding Cassettes during the Catalytic Cycle of ATP-binding Cassette Transporters by Moody, Jonathan E, Millen, Linda, Binns, Derk, Hunt, John F, Thomas, Philip J

“…ATP-binding cassette (ABC) transporters harvest the energy present in cellular ATP to drive the translocation of a structurally diverse set of solutes across…”
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Palmitoylation and Membrane Binding of Arc/Arg3.1: A Potential Role in Synaptic Depression by Barylko, Barbara, Wilkerson, Julia R, Cavalier, Sheridan H, Binns, Derk D, James, Nicholas G, Jameson, David M, Huber, Kimberly M, Albanesi, Joseph P

“…Activity-regulated cytoskeletal-associated protein (Arc, also known as activity-regulated gene 3.1 or Arg3.1) is induced in neurons in response to salient…”
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Dynamin GTPase domain mutants block endocytic vesicle formation at morphologically distinct stages by Damke, H, Binns, D D, Ueda, H, Schmid, S L, Baba, T

“…Abundant evidence has shown that the GTPase dynamin is required for receptor-mediated endocytosis, but its exact role in endocytic clathrin-coated vesicle…”
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Dynamin2 and Cortactin Regulate Actin Assembly and Filament Organization by Schafer, Dorothy A., Weed, Scott A., Binns, Derk, Karginov, Andrei V., Parsons, J.Thomas, Cooper, John A.

“…The GTPase dynamin is required for endocytic vesicle formation. Dynamin has also been implicated in regulating the actin cytoskeleton, but the mechanism by…”
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The Proline/Arginine-Rich Domain Is a Major Determinant of Dynamin Self-Activation by Barylko, Barbara, Wang, Lei, Binns, Derk D, Ross, Justin A, Tassin, Tara C, Collins, Katie A, Jameson, David M, Albanesi, Joseph P

“…Dynamins induce membrane vesiculation during endocytosis and Golgi budding in a process that requires assembly-dependent GTPase activation. Brain-specific…”
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