Search Results - "Binnie, Alexandra"

Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers by Almeida, Bernardo, Apolónio, Joana Dias, Binnie, Alexandra, Castelo Branco, Pedro

“…© The Author(s). 2019. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License…”
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Epigenetics of Sepsis by Binnie, Alexandra, Tsang, Jennifer L. Y., Hu, Pingzhao, Carrasqueiro, Gabriela, Castelo-Branco, Pedro, dos Santos, Claudia C.

“…OBJECTIVES:Recent evidence from the fields of microbiology and immunology, as well as a small number of human sepsis studies, suggest that epigenetic…”
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The research activities of Ontario's large community hospitals: an updated scoping review by Rego, Kian, Jomy, Jane, Patel, Prey, DiDiodato, Giulio, Nademi, Ashton, Binnie, Alexandra, Tsang, Jennifer

“…Community hospitals provide the majority of patient care in Canada but traditionally do not participate in clinical research. The disconnect between where most…”
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The impact of COVID-19 workload on psychological distress amongst Canadian intensive care unit healthcare workers during the 1st wave of the COVID-19 pandemic: A longitudinal cohort study by Pestana, Daniel, Moura, Kyra, Moura, Claire, Mouliakis, Taylor, D'Aragon, Frédérick, Tsang, Jennifer L Y, Binnie, Alexandra

“…Intensive care unit healthcare workers (ICU HCW) are at risk of mental health disorders during emerging disease outbreaks. Numerous cross-sectional studies…”
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Psychosocial distress amongst Canadian intensive care unit healthcare workers during the acceleration phase of the COVID-19 pandemic by Binnie, Alexandra, Moura, Kyra, Moura, Claire, D'Aragon, Frédérick, Tsang, Jennifer L. Y

“…Intensive care unit healthcare workers (ICU HCW) are at risk of mental health issues during emerging disease outbreaks. A study of ICU HCW from France revealed…”
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COVID-19 research in critical care: the good, the bad, and the ugly by Salluh, Jorge I. F., Arabi, Yaseen M., Binnie, Alexandra

“…The extraordinary pace of research on coronavirus disease 2019 (COVID-19) has been one of the major success stories of the pandemic. Therapeutic trials…”
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Barriers to participation in biosampling-based translational research: A cross-sectional survey of Canadian critical care researchers by Cani, Erblin, Tsang, Jennifer L Y, Binnie, Alexandra, Dos Santos, Claudia C, Fowler, Robert, Lamontagne, Francois, Mehta, Sangeeta, Liaw, Patricia C

“…Collection of biosamples for translational research studies is vital for understanding biological pathways, discovering disease-related biomarkers, and…”
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Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness by Binnie, Alexandra, Walsh, Christopher J, Hu, Pingzhao, Dwivedi, Dhruva J, Fox-Robichaud, Alison, Liaw, Patricia C, Tsang, Jennifer L Y, Batt, Jane, Carrasqueiro, Gabriela, Gupta, Sahil, Marshall, John C, Castelo-Branco, Pedro, dos Santos, Claudia C

“…OBJECTIVES:Epigenetic alterations are an important regulator of gene expression in health and disease; however, epigenetic data in sepsis are lacking. To…”
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Motivating factors, barriers and facilitators of participation in COVID-19 clinical research: A cross-sectional survey of Canadian community intensive care units by Tsang, Jennifer L Y, Fowler, Robert, Cook, Deborah J, Burns, Karen E A, Hunter, Kylee, Forcina, Victoria, Hwang, Anna, Duan, Erick, Patterson, Lisa, Binnie, Alexandra

“…Only a small proportion of COVID-19 patients in Canada have been recruited into clinical research studies. One reason is that few community intensive care…”
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Fostering community hospital research by Gehrke, Paige, RN BScN, Tsang, Jennifer L.Y., MD PhD, Chan, Stephanie P.T., MD, Binnie, Alexandra, MD DPhil, Rewa, Oleksa G., MD MSc, Herridge, Margaret, MSc MD MPH, Burns, Karen E.A., MD MSc, Cook, Deborah J., MD MSc

“…The traditional setting of health research is academic centres. However, Canadian health care could benefit from research conducted and started in centres…”
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Proton pump inhibitors in critically ill mechanically ventilated patients with COVID-19: protocol for a substudy of the Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial by Dennis, Brittany B, Thabane, Lehana, Heels-Ansdell, Diane, Dionne, Joanna C, Binnie, Alexandra, Tsang, Jennifer, Guyatt, Gordon, Ahmed, Aijaz, Lauzier, François, Deane, Adam, Arabi, Yaseen, Marshall, John, Zytaruk, Nicole, Saunders, Lois, Finfer, Simon, Myburgh, John, Muscedere, John, English, Shane, Ostermann, Marlies, Hardie, Miranda, Knowles, Serena, Cook, Deborah

“…Abstract Background Critically ill patients commonly receive proton pump inhibitors (PPIs) to prevent gastrointestinal (GI) bleeding from stress-induced…”
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The impact of small-group virtual patient simulator training on perceptions of individual learning process and curricular integration: a multicentre cohort study of nursing and medical students by Mestre, André, Muster, Marek, El Adib, Ahmed Rhassane, Ösp Egilsdottir, Hugrun, Byermoen, Kirsten Røland, Padilha, Miguel, Aguilar, Thania, Tabagari, Nino, Betts, Lorraine, Sales, Leila, Garcia, Pedro, Ling, Luo, Café, Hugo, Binnie, Alexandra, Marreiros, Ana

“…The COVID-19 pandemic has precipitated rapid changes in medical education to protect students and patients from the risk of infection. Virtual Patient…”
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Characterizing Risk Factors for Hospitalization and Clinical Characteristics in a Cohort of COVID-19 Patients Enrolled in the GENCOV Study by Morgan, Gregory, Casalino, Selina, Chowdhary, Sunakshi, Frangione, Erika, Fung, Chun Yiu Jordan, Haller, Simona, Lapadula, Elisa, Scott, Mackenzie, Wolday, Dawit, Young, Juliet, Arnoldo, Saranya, Aujla, Navneet, Bearss, Erin, Binnie, Alexandra, Bombard, Yvonne, Borgundvaag, Bjug, Briollais, Laurent, Dagher, Marc, Devine, Luke, Faghfoury, Hanna, Friedman, Steven M, Gingras, Anne-Claude, Goneau, Lee W, Khan, Zeeshan, Mazzulli, Tony, McLeod, Shelley L, Nomigolzar, Romina, Noor, Abdul, Pugh, Trevor J, Richardson, David, Satnam Singh, Harpreet Kaur, Simpson, Jared, Stern, Seth, Strug, Lisa, Taher, Ahmed, Lerner-Ellis, Jordan, Taher, Jennifer

“…The GENCOV study aims to identify patient factors which affect COVID-19 severity and outcomes. Here, we aimed to evaluate patient characteristics, acute…”
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Promoter proximal splice sites enhance transcription by Furger, Andre, O'Sullivan, Justin M, Binnie, Alexandra, Lee, Barbara A, Proudfoot, Nick J

“…Reconstruction of a gene with its introns removed results in reduced levels of cytoplasmic mRNA. This is partly explained by introns promoting the export of…”
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Association of Epigenetic Age and Outcome in Critically Ill Patients by Sharma-Oates, Archana, Sullivan, Jack, Pestana, Daniel, Dos Santos, Claudia C, Binnie, Alexandra, Lord, Janet M

“…DNA methylation can be used to determine an individual's biological age, as opposed to chronological age, an indicator of underlying health status. This study…”
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Implementation of serological and molecular tools to inform COVID-19 patient management: protocol for the GENCOV prospective cohort study by Taher, Jennifer, Mighton, Chloe, Chowdhary, Sunakshi, Casalino, Selina, Frangione, Erika, Arnoldo, Saranya, Bearss, Erin, Binnie, Alexandra, Bombard, Yvonne, Borgundvaag, Bjug, Chertkow, Howard, Clausen, Marc, Devine, Luke, Faghfoury, Hanna, Friedman, Steven Marc, Gingras, Anne-Claude, Khan, Zeeshan, Mazzulli, Tony, McGeer, Allison, McLeod, Shelley L, Pugh, Trevor J, Richardson, David, Simpson, Jared, Stern, Seth, Strug, Lisa, Taher, Ahmed, Lerner-Ellis, Jordan

“…IntroductionThere is considerable variability in symptoms and severity of COVID-19 among patients infected by the SARS-CoV-2 virus. Linking host and virus…”
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P709: Self reported vs genetic ancestry from the GENCOV COVID-19 genomic sequencing study by Frangione, Erika, Casalino, Selina, Aujla, Navneet, Mahajan, Radhika, Jayachandran, Lochana, Morgan, Gregory, Scott, Mackenzie, Young, Juliet, Dickson, Brendan, Arnoldo, Saranya, Bearss, Erin, Binnie, Alexandra, Borgundvaag, Bjug, Chertkow, Howard, Clausen, Marc, Dagher, Marc, Devine, Luke, Friedman, Steven, Gingras, Anne-Claude, Goneau, Lee, Kaushik, Deepanjali, Khan, Zeeshan, Lapadula, Elisa, MacDonald, Georgia, Mazzulli, Tony, McGeer, Allison, McLeod, Shelley, Mighton, Chloe, Pugh, Trevor, Richardson, David, Simpson, Jared, Stern, Seth, Strug, Lisa, Taher, Ahmed, Wong, Iris, Zarei, Natasha, Greenfeld, Elena, Bombard, Yvonne, Noor, Abdul, Faghfoury, Hanna, Taher, Jennifer, Lerner-Ellis, Jordan

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P710: Phenome-wide association study (PheWAS) for the Canadian HostSeq Biobank by Frangione, Erika, Xinyi, Xu, Chapdelaine, Vincent, Casalino, Selina, Aujla, Navneet, Mahajan, Radhika, Jayachandran, Lochana, Morgan, Gregory, Scott, Mackenzie, Young, Juliet, Dickson, Brendan, Arnoldo, Saranya, Bearss, Erin, Binnie, Alexandra, Borgundvaag, Bjug, Chertkow, Howard, Clausen, Marc, Dagher, Marc, Devine, Luke, Friedman, Steven, Gingras, Anne-Claude, Goneau, Lee, Kaushik, Deepanjali, Khan, Zeeshan, Lapadula, Elisa, MacDonald, Georgia, Mazzulli, Tony, McGeer, Allison, McLeod, Shelley, Mighton, Chloe, Pugh, Trevor, Richardson, David, Simpson, Jared, Stern, Seth, Strug, Lisa, Taher, Ahmed, Wong, Iris, Zarei, Natasha, Greenfeld, Elena, Bombard, Yvonne, Noor, Abdul, Faghfoury, Hanna, Taher, Jennifer, Taliun, Daniel, Lerner-Ellis, Jordan

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P733: Comparative analysis of DNA variant classifications between the GENCOV COVID-19 genome study and the ClinVar database by Mahajan, Radhika, Frangione, Erika, Aujla, Navneet, Casalino, Selina, Jayachandran, Lochana, Morgan, Gregory, Young, Juliet, Dickson, Brendan, Arnoldo, Saranya, Bearss, Erin, Binnie, Alexandra, Borgundvaag, Bjug, Clausen, Marc, Dagher, Marc, Devine, Luke, Friedman, Steven, Gingras, Anne-Claude, Khan, Zeeshan, Mazzulli, Tony, McLeod, Shelley, Mighton, Chloe, Pugh, Trevor, Simpson, Jared, Stern, Seth, Strug, Lisa, Taher, Ahmed, Greenfeld, Elena, Bombard, Yvonne, Noor, Abdul, Faghfoury, Hanna, Taher, Jennifer, Lerner-Ellis, Jordan

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Academic and Community ICUs Participating in a Critical Care Randomized Trial: A Comparison of Patient Characteristics and Trial Metrics by Tsang, Jennifer L. Y., Binnie, Alexandra, Duan, Erick H., Johnstone, Jennie, Heels-Ansdell, Diane, Reeve, Brenda, Trop, Sebastien, Hosek, Paul, Dionne, Joanna C., Archambault, Patrick, Lysecki, Paul, Cirone, Robert, Zytaruk, Nicole L., Dechert, William, Camargo, Mercedes Peñuela, Jesso, Rebecca, McMillan, Elliot, Panchbhaya, Zaynab, Campbell, Tracy, Saunders, Lois, Copland, Mary, Kavikondala, Kanthi, Cook, Deborah J.

“…OBJECTIVES: Clinical research in Canada is conducted primarily in “academic” hospitals, whereas most clinical care is provided in “community” hospitals. The…”
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