Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection

This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalized coronavirus disease 2019 (COVID-19) adult patients enrolled in the National Clinical Registry for COVID-19 (NCRC). NCRC is an on-going data collection platform operational in...

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Bibliographic Details
Published in:	QJM : An International Journal of Medicine Vol. 116; no. 1; pp. 47 - 56
Main Authors:	Mukherjee, A, Kumar, G, Turuk, A, Bhalla, A, Bingi, T C, Bhardwaj, P, Baruah, T D, Mukherjee, S, Talukdar, A, Ray, Y, John, M, Khambholja, J R, Patel, A H, Bhuniya, S, Joshi, R, Menon, G R, Sahu, D, Rao, V V, Bhargava, B, Panda, S
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 14-02-2023
Subjects:	Adult Chronic Disease COVID-19 - prevention & control Hospital Mortality Humans Male Middle Aged Original SARS-CoV-2 Time and Motion Studies Vaccination
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Summary:	This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalized coronavirus disease 2019 (COVID-19) adult patients enrolled in the National Clinical Registry for COVID-19 (NCRC). NCRC is an on-going data collection platform operational in 42 hospitals across India. Data of hospitalized COVID-19 patients enrolled in NCRC between 1st September 2020 to 26th October 2021 were examined. Analysis of 29 509 hospitalized, adult COVID-19 patients [mean (SD) age: 51.1 (16.2) year; male: 18 752 (63.6%)] showed that 15 678 (53.1%) had at least one comorbidity. Among 25 715 (87.1%) symptomatic patients, fever was the commonest symptom (72.3%) followed by shortness of breath (48.9%) and dry cough (45.5%). In-hospital mortality was 14.5% (n = 3957). Adjusted odds of dying were significantly higher in age group ≥60 years, males, with diabetes, chronic kidney diseases, chronic liver disease, malignancy and tuberculosis, presenting with dyspnoea and neurological symptoms. WHO ordinal scale 4 or above at admission carried the highest odds of dying [5.6 (95% CI: 4.6-7.0)]. Patients receiving one [OR: 0.5 (95% CI: 0.4-0.7)] or two doses of anti-SARS CoV-2 vaccine [OR: 0.4 (95% CI: 0.3-0.7)] were protected from in-hospital mortality. WHO ordinal scale at admission is the most important independent predictor for in-hospital death in COVID-19 patients. Anti-SARS-CoV2 vaccination provides significant protection against mortality.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Aparna Mukherjee, Gunjan Kumar. These authors have contributed equally to this work.
ISSN:	1460-2725 1460-2393
DOI:	10.1093/qjmed/hcac202