Search Results - "Bingham, Richard J."

Assembly of infectious enteroviruses depends on multiple, conserved genomic RNA-coat protein contacts by Chandler-Bostock, Rebecca, Mata, Carlos P, Bingham, Richard J, Dykeman, Eric C, Meng, Bo, Tuthill, Tobias J, Rowlands, David J, Ranson, Neil A, Twarock, Reidun, Stockley, Peter G

“…Picornaviruses are important viral pathogens, but despite extensive study, the assembly process of their infectious virions is still incompletely understood,…”
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An age-structured model of hepatitis B viral infection highlights the potential of different therapeutic strategies by Fatehi, Farzad, Bingham, Richard J., Stockley, Peter G., Twarock, Reidun

“…Hepatitis B virus (HBV) is a global health threat, and its elimination by 2030 has been prioritised by the World Health Organisation. Here we present an…”
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Flexibility and intrinsic disorder are conserved features of hepatitis C virus E2 glycoprotein by Stejskal, Lenka, Lees, William D, Moss, David S, Palor, Machaela, Bingham, Richard J, Shepherd, Adrian J, Grove, Joe

“…The glycoproteins of hepatitis C virus, E1E2, are unlike any other viral fusion machinery yet described, and are the current focus of immunogen design in HCV…”
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An Intracellular Model of Hepatitis B Viral Infection: An In Silico Platform for Comparing Therapeutic Strategies by Fatehi, Farzad, Bingham, Richard J, Dykeman, Eric C, Patel, Nikesh, Stockley, Peter G, Twarock, Reidun

“…Hepatitis B virus (HBV) is a major focus of antiviral research worldwide. The International Coalition to Eliminate HBV, together with the World Health…”
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Therapeutic interfering particles exploiting viral replication and assembly mechanisms show promising performance: a modelling study by Fatehi, Farzad, Bingham, Richard J., Dechant, Pierre-Philippe, Stockley, Peter G., Twarock, Reidun

“…Defective interfering particles arise spontaneously during a viral infection as mutants lacking essential parts of the viral genome. Their ability to replicate…”
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RNA Virus Evolution via a Quasispecies-Based Model Reveals a Drug Target with a High Barrier to Resistance by Bingham, Richard J, Dykeman, Eric C, Twarock, Reidun

“…The rapid occurrence of therapy-resistant mutant strains provides a challenge for anti-viral therapy. An ideal drug target would be a highly conserved…”
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Staphylococcal biofilm-forming protein has a contiguous rod-like structure by Gruszka, Dominika T, Wojdyla, Justyna A, Bingham, Richard J, Turkenburg, Johan P, Manfield, Iain W, Steward, Annette, Leech, Andrew P, Geoghegan, Joan A, Foster, Timothy J, Clarke, Jane, Potts, Jennifer R

“…Staphylococcus aureus and Staphylococcus epidermidis form communities (called biofilms) on inserted medical devices, leading to infections that affect many…”
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Crystal Structures of Fibronectin-Binding Sites from Staphylococcus aureus FnBPA in Complex with Fibronectin Domains by Bingham, Richard J., Rudiño-Piñera, Enrique, Meenan, Nicola A. G., Schwarz-Linek, Ulrich, Turkenburg, Johan P., Höök, Magnus, Garman, Elspeth F., Potts, Jennifer R.

“…Staphylococcus aureus can adhere to and invade endothelial cells by binding to the human protein fibronectin (Fn). FnBPA and FnBPB, cell wall-attached proteins…”
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Van der Waals Interactions Dominate Ligand−Protein Association in a Protein Binding Site Occluded from Solvent Water by Barratt, Elizabeth, Bingham, Richard J, Warner, Daniel J, Laughton, Charles A, Phillips, Simon E. V, Homans, Steve W

“…In the present study we examine the enthalpy of binding of 2-methoxy-3-isobutylpyrazine (IBMP) to the mouse major urinary protein (MUP), using a combination of…”
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The Borrelia afzelii outer membrane protein BAPKO_0422 binds human factor-H and is predicted to form a membrane-spanning β-barrel by Dyer, Adam, Brown, Gemma, Stejskal, Lenka, Laity, Peter R, Bingham, Richard J

“…The deep evolutionary history of the Spirochetes places their branch point early in the evolution of the diderms, before the divergence of the present day…”
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Computational Study of Room-Temperature Ionic Liquids Interacting with a POPC Phospholipid Bilayer by Bingham, Richard J, Ballone, Pietro

“…Molecular dynamics simulations based on an empirical force field have been carried out to investigate the properties of a zwitter-ionic phospholipid (POPC)…”
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Fibronectin Structure: A New Piece of the Puzzle Emerges by Bingham, Richard J., Potts, Jennifer R.

“…In the structure of the gelatin binding domain (GBD) of fibronectin reported by Graille et al. (2010), both the zinc-mediated dimerization and the…”
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Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein by Tetter, Stephan, Terasaka, Naohiro, Steinauer, Angela, Bingham, Richard J, Clark, Sam, Scott, Andrew J P, Patel, Nikesh, Leibundgut, Marc, Wroblewski, Emma, Ban, Nenad, Stockley, Peter G, Twarock, Reidun, Hilvert, Donald

“…Viruses are ubiquitous pathogens of global impact. Prompted by the hypothesis that their earliest progenitors recruited host proteins for virion formation, we…”
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A modelling paradigm for RNA virus assembly by Twarock, Reidun, Bingham, Richard J, Dykeman, Eric C, Stockley, Peter G

“…•Multiple, common dispersed packaging signals (PSs) promote RNA virus assembly.•PS-mediated assembly solves a viral equivalent of Levinthal’s Paradox.•RNA PSs…”
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Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein by Bingham, Richard J., Findlay, John B. C., Hsieh, Shih-Yang, Kalverda, Arnout P., Kjellberg, Alexandra, Perazzolo, Chiara, Phillips, Simon E. V., Seshadri, Kothandaraman, Trinh, Chi H., Turnbull, W. Bruce, Bodenhausen, Geoffrey, Homans, Steve W.

“…In the present study we examine the thermodynamics of binding of two related pyrazine-derived ligands to the major urinary protein, MUP-I, using a combination…”
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Dynamic network approach for the modelling of genomic sub-complexes in multi-segmented viruses by AlShaikhahmed, Kinda, Leonov, German, Sung, Po-Yu, Bingham, Richard J, Twarock, Reidun, Roy, Polly

“…Abstract Viruses with segmented genomes, including pathogens such as influenza virus, Rotavirus and Bluetongue virus (BTV), face the collective challenge of…”
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Structure and dynamics of POPC bilayers in water solutions of room temperature ionic liquids by Benedetto, Antonio, Bingham, Richard J, Ballone, Pietro

“…Molecular dynamics simulations in the NPT ensemble have been carried out to investigate the effect of two room temperature ionic liquids (RTILs), on stacks of…”
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Genome-regulated Assembly of a ssRNA Virus May Also Prepare It for Infection by Chandler-Bostock, Rebecca, Bingham, Richard J., Clark, Sam, Scott, Andrew J.P., Wroblewski, Emma, Barker, Amy, White, Simon J., Dykeman, Eric C., Mata, Carlos P., Bohon, Jen, Farquhar, Erik, Twarock, Reidun, Stockley, Peter G.

“…[Display omitted] •The genome of a ssRNA virus contributes both to virion assembly and infection.•RNA X-ray footprinting confirms that multiple PSs contact the…”
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Crystal structure and molecular dynamics of human POLDIP2, a multifaceted adaptor protein in metabolism and genome stability by Kulik, Anastasija A., Maruszczak, Klaudia K., Thomas, Dana C., Nabi‐Aldridge, Naomi L. A., Carr, Martin, Bingham, Richard J., Cooper, Christopher D. O.

“…Polymerase δ‐interacting protein 2 (POLDIP2, PDIP38) is a multifaceted, “moonlighting” protein, involved in binding protein partners from many different…”
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Drosophila melanogaster NEP2 is a new soluble member of the neprilysin family of endopeptidases with implications for reproduction and renal function by Thomas, Josie E, Rylett, Caroline M, Carhan, Ahmet, Bland, Nicholas D, Bingham, Richard J, Shirras, Alan D, Turner, Anthony J, Isaac, R Elwyn

“…The mammalian neprilysin (NEP) family members are typically type II membrane endopeptidases responsible for the activation/inactivation of neuropeptides and…”
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