Hemophagocytic Lymphohistiocytosis in Visceral Leishmaniasis: A Rare yet Treatable Complication

Hemophagocytic Lymphohistiocytosis in Visceral Leishmaniasis: A Rare yet Treatable Complication

Hemophagocytic lymphohistiocytosis (HLH) is a rare debilitating condition that can be triggered by an infectious cause, often linked to the Epstein-Barr virus (EBV). In this case, we evaluated a patient with pancytopenia. The bone marrow aspiration revealed the presence of amastigotes and active hem...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) Vol. 16; no. 9; p. e70104
Main Authors: Varshney, Anupam, Solanki, Ranjan, Manna, David, Rodriguez, Efren, Bindra, Vijay K
Format: Journal Article
Language:English
Published: United States Cureus 24-09-2024
Subjects:
Hematology
Infectious Disease
Pathology
bone marrow aspirate
hemophagocytic lymphohistiocytosis
pancytopenia
leishmania
amastigote forms
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Summary:Hemophagocytic lymphohistiocytosis (HLH) is a rare debilitating condition that can be triggered by an infectious cause, often linked to the Epstein-Barr virus (EBV). In this case, we evaluated a patient with pancytopenia. The bone marrow aspiration revealed the presence of amastigotes and active hemophagocytosis, indicating that the HLH was induced by a infection. The patient was treated with lyophilized amphotericin B followed by miltefosine, which effectively resolved the infection and HLH. This case report underscores the presentation and findings of -induced HLH, as well as the successful treatment approach that led to improved patient outcomes.
Bibliography:ObjectType-Case Study-2
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.70104