Search Results - "Bindokas, Vytautas"

Tumor-associated fibroblasts predominantly come from local and not circulating precursors by Arina, Ainhoa, Idel, Christian, Hyjek, Elizabeth M., Alegre, Maria-Luisa, Wang, Ying, Bindokas, Vytautas P., Weichselbaum, Ralph R., Schreiber, Hans

“…Fibroblasts are common cell types in cancer stroma and lay down collagen required for survival and growth of cancer cells. Although some cancer therapy…”
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Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment by Lee, Steve Seung-Young, Bindokas, Vytautas P, Kron, Stephen J

“…Macromolecular cancer drugs such as therapeutic antibodies and nanoparticles are well known to display slow extravasation and incomplete penetration into…”
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Multiplex three-dimensional optical mapping of tumor immune microenvironment by Lee, Steve Seung-Young, Bindokas, Vytautas P., Kron, Stephen J.

“…Recent developments in optical tissue clearing and microscopic imaging have advanced three-dimensional (3D) visualization of intact tissues and organs at high…”
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Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase by Buggia-Prévot, Virginie, Fernandez, Celia G, Riordan, Sean, Vetrivel, Kulandaivelu S, Roseman, Jelita, Waters, Jack, Bindokas, Vytautas P, Vassar, Robert, Thinakaran, Gopal

“…BACE1 is one of the two enzymes that cleave amyloid precursor protein to generate Alzheimer's disease (AD) beta amyloid peptides. It is widely believed that…”
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Multiresolution 3D Optical Mapping of Immune Cell Infiltrates in Mouse Asthmatic Lung by Wu, Yi-Chien, Moon, Hyung-Geun, Bindokas, Vytautas P, Phillips, Evan H, Park, Gye Young, Lee, Steve Seung-Young

“…Asthma is a chronic inflammatory airway disease driven by various infiltrating immune cell types into the lung. Optical microscopy has been used to study…”
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O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors by Efimova, Elena V, Appelbe, Oliver K, Ricco, Natalia, Lee, Steve S-Y, Liu, Yue, Wolfgeher, Donald J, Collins, Tamica N, Flor, Amy C, Ramamurthy, Aishwarya, Warrington, Sara, Bindokas, Vytautas P, Kron, Stephen J

“…The metabolic reprogramming associated with characteristic increases in glucose and glutamine metabolism in advanced cancer is often ascribed to answering a…”
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Nondestructive, multiplex three-dimensional mapping of immune infiltrates in core needle biopsy by Lee, Steve Seung-Young, Bindokas, Vytautas P., Lingen, Mark W., Kron, Stephen J.

“…Enumeration of tumor-infiltrating lymphocytes (TILs) in H&E stained tissue sections has demonstrated limited value in predicting immune responses to cancer…”
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TRPC6 channel translocation into phagosomal membrane augments phagosomal function by Riazanski, Vladimir, Gabdoulkhakova, Aida G., Boynton, Lin S., Eguchi, Raphael R., Deriy, Ludmila V., Hogarth, D. Kyle, Loaëc, Nadège, Oumata, Nassima, Galons, Hervé, Brown, Mary E., Shevchenko, Pavel, Gallan, Alexander J., Yoo, Sang Gune, Naren, Anjaparavanda P., Villereal, Mitchel L., Beacham, Daniel W., Bindokas, Vytautas P., Birnbaumer, Lutz, Meijer, Laurent, Nelson, Deborah J.

“…Defects in the innate immune system in the lung with attendant bacterial infections contribute to lung tissue damage, respiratory insufficiency, and ultimately…”
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A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer’s Disease Aβ Production by Buggia-Prévot, Virginie, Fernandez, Celia G., Udayar, Vinod, Vetrivel, Kulandaivelu S., Elie, Aureliane, Roseman, Jelita, Sasse, Verena A., Lefkow, Margaret, Meckler, Xavier, Bhattacharyya, Sohinee, George, Manju, Kar, Satyabrata, Bindokas, Vytautas P., Parent, Angèle T., Rajendran, Lawrence, Band, Hamid, Vassar, Robert, Thinakaran, Gopal

“…Abnormal accumulation of β-secretase (BACE1) in dystrophic neurites and presynaptic β-amyloid (Aβ) production contribute to Alzheimer's disease pathogenesis…”
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Mitochondrial mechanisms of neuronal rescue by F-68, a hydrophilic Pluronic block co-polymer, following acute substrate deprivation by Wang, Janice C., Bindokas, Vytautas P., Skinner, Matthew, Emrick, Todd, Marks, Jeremy D.

“…Global brain ischemia can lead to widespread neuronal death and poor neurologic outcomes in patients. Despite detailed understanding of the cellular and…”
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Critical role of microbiota within cecal crypts on the regenerative capacity of the intestinal epithelium following surgical stress by Zaborin, Alexander, Krezalek, Monika, Hyoju, Sanjiv, Defazio, Jennifer R, Setia, Namrata, Belogortseva, Natalia, Bindokas, Vytautas P, Guo, Qiti, Zaborina, Olga, Alverdy, John C

“…Cecal crypts represent a unique niche that are normally occupied by the commensal microbiota. Due to their density and close proximity to stem cells,…”
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Disease-causing Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator Determine the Functional Responses of Alveolar Macrophages by Deriy, Ludmila V., Gomez, Erwin A., Zhang, Guangping, Beacham, Daniel W., Hopson, Jessika A., Gallan, Alexander J., Shevchenko, Pavel D., Bindokas, Vytautas P., Nelson, Deborah J.

“…Alveolar macrophages (AMs) play a major role in host defense against microbial infections in the lung. To perform this function, these cells must ingest and…”
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Three-dimensional spatial quantitative analysis of cardiac lymphatics in the mouse heart by Phillips, Evan H, Bindokas, Vytautas P, Jung, Dahee, Teamer, Jay, Kitajewski, Jan K, Solaro, R John, Wolska, Beata M, Lee, Steve Seung-Young

“…Three-dimensional (3D) microscopy and image data analysis are necessary for studying the morphology of cardiac lymphatic vessels (LyVs) and their association…”
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Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis by Zhong, Rong, Bao, Riyue, Faber, Pieter W, Bindokas, Vytautas P, Bechill, John, Lingen, Mark W, Spiotto, Michael T

“…Viral oncogene expression is insufficient for neoplastic transformation of human cells, so human papillomavirus (HPV)-associated cancers will also rely upon…”
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Poly(ADP-Ribose) Polymerase Inhibitor Induces Accelerated Senescence in Irradiated Breast Cancer Cells and Tumors by EFIMOVA, Elena V, MAUCERI, Helena J, KRON, Stephen J, WEICHSELBAUM, Ralph R, GOLDEN, Daniel W, LABAY, Edwardine, BINDOKAS, Vytautas P, DARGA, Thomas E, CHAKRABORTY, Chaitali, CAMILO BARRETO-ANDRADE, Juan, CRAWLEY, Clayton, SUTTON, Harold G

“…Persistent DNA double-strand breaks (DSB) may determine the antitumor effects of ionizing radiation (IR) by inducing apoptosis, necrosis, mitotic catastrophe,…”
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Drug-Paired Contextual Stimuli Increase Dendritic Spine Dynamics in Select Nucleus Accumbens Neurons by Singer, Bryan F, Bubula, Nancy, Li, Dongdong, Przybycien-Szymanska, Magdalena M, Bindokas, Vytautas P, Vezina, Paul

“…Repeated exposure to amphetamine leads to both associative conditioning and nonassociative sensitization. Here we assessed the contribution of neuronal…”
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Visualizing Superoxide Production in Normal and Diabetic Rat Islets of Langerhans by Bindokas, Vytautas P, Kuznetsov, Andrey, Sreenan, Seamus, Polonsky, Kenneth S, Roe, Michael W, Philipson, Louis H

“…Oxygen free radicals have been implicated in β-cell dysfunction and apoptosis associated with type 1 and type 2 diabetes mellitus. The roles of free radicals…”
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Polyglutamine protein aggregates are dynamic by Morimoto, Richard I, Kim, Soojin, Nollen, Ellen A. A, Kitagawa, Kazunori, Bindokas, Vytautas P

“…Protein aggregation and the formation of inclusion bodies are hallmarks of the cytopathology of neurodegenerative diseases, including Huntington's disease,…”
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The Granular Chloride Channel ClC-3 Is Permissive for Insulin Secretion by Deriy, Ludmila V., Gomez, Erwin A., Jacobson, David A., Wang, XueQing, Hopson, Jessika A., Liu, Xiang Y., Zhang, Guangping, Bindokas, Vytautas P., Philipson, Louis H., Nelson, Deborah J.

“…Insulin secretion from pancreatic β cells is dependent on maturation and acidification of the secretory granule, processes necessary for prohormone convertase…”
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Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: Relevance to lung cancer by Kawada, Ichiro, Hasina, Rifat, Lennon, Frances E, Bindokas, Vytautas P, Usatyuk, Peter, Tan, Yi-Hung C, Krishnaswamy, Soundararajan, Arif, Qudsia, Carey, George, Hseu, Robyn D, Robinson, Matthew, Tretiakova, Maria, Brand, Toni M, Iida, Mari, Ferguson, Mark K, Wheeler, Deric L., Husain, Aliya N, Natarajan, Viswanathan, Vokes, Everett E, Singleton, Patrick A, Salgia, Ravi

“…Cytoskeletal and focal adhesion abnormalities are observed in several types of cancer, including lung cancer. We have previously reported that paxillin (PXN)…”
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