Sarcoma Patients Admitted to the Intensive Care Unit (ICU): Predictive Relevance of Common Sepsis and Performance Parameters

Sarcoma Patients Admitted to the Intensive Care Unit (ICU): Predictive Relevance of Common Sepsis and Performance Parameters

Prognosis of sarcoma patients is improving, with a better understanding of sarcomagenesis revealing novel therapeutic targets. However, aggressive chemotherapy remains an essential part of treatment, bearing the risk of severe side effects that require intensive medical treatment. Available data on...

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Bibliographic Details
Published in:Cancer management and research Vol. 15; pp. 321 - 334
Main Authors: Striefler, Jana K, Binder, Phung T, Brandes, Franziska, Rau, Daniel, Wittenberg, Silvan, Kaul, David, Roohani, Siyer, Jarosch, Armin, Schäfer, Frederik M, Öllinger, Robert, Märdian, Sven, Bullinger, Lars, Eckardt, Kai-Uwe, Kruse, Jan, Flörcken, Anne
Format: Journal Article
Language:English
Published: New Zealand Dove Medical Press Limited 01-01-2023
Dove
Dove Medical Press
Subjects:
Analysis
Cancer
Care and treatment
Chemotherapy
Health aspects
icu specific survival
intensive care unit
Original Research
Prognosis
saps ii
Sarcoma
sepsis and performance scores
sofa
soft tissue sarcoma
Germany
SOFA
SAPS II
intensive care unit
sepsis and performance scores
ICU-specific survival
soft tissue sarcoma
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Summary:Prognosis of sarcoma patients is improving, with a better understanding of sarcomagenesis revealing novel therapeutic targets. However, aggressive chemotherapy remains an essential part of treatment, bearing the risk of severe side effects that require intensive medical treatment. Available data on the characteristics and clinical outcome of sarcoma patients admitted to intensive care units (ICU) are sparse. We performed a retrospective analysis of sarcoma patients admitted to the ICU from 2005 to 2022. Patients ≥18 years with histologically proven sarcoma were included in our study. Sixty-six patients were eligible for analysis. The following characteristics had significant impact on overall survival: sex (p=0.046), tumour localization (p=0.02), therapeutic intention (p=0.02), line of chemotherapy (p<0.001), SAPS II score (p=0.03) and SOFA score (p=0.02). Our study confirms the predictive relevance of established sepsis and performance scores in sarcoma patients. For overall survival, common clinical characteristics are also of significant value. Further investigation is needed to optimize ICU treatment of sarcoma patients.
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ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S400430