Search Results - "Binder, Devin"

The role of aquaporin-4 in synaptic plasticity, memory and disease by Hubbard, Jacqueline A, Szu, Jenny I, Binder, Devin K

“…Highlights • AQP4−/− mice have memory deficits and impaired long-term potentiation. • AQP4 expression is altered in AD, ALS, MS, and after TBI. • The formation…”
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Astrocytes and Epilepsy by Binder, Devin K., Steinhäuser, Christian

“…Changes in astrocyte channels, transporters, and metabolism play a critical role in seizure generation and epilepsy. In particular, alterations in astrocyte…”
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Translation-relevant EEG phenotypes in a mouse model of Fragile X Syndrome by Lovelace, Jonathan W., Ethell, Iryna M., Binder, Devin K., Razak, Khaleel A.

“…Identification of comparable biomarkers in humans and validated animal models will facilitate pre-clinical to clinical therapeutic pipelines to treat…”
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Genetic Reduction of Matrix Metalloproteinase-9 Promotes Formation of Perineuronal Nets Around Parvalbumin-Expressing Interneurons and Normalizes Auditory Cortex Responses in Developing Fmr1 Knock-Out Mice by Wen, Teresa H, Afroz, Sonia, Reinhard, Sarah M, Palacios, Arnold R, Tapia, Kendal, Binder, Devin K, Razak, Khaleel A, Ethell, Iryna M

“…Abstract Abnormal sensory responses associated with Fragile X Syndrome (FXS) and autism spectrum disorders include hypersensitivity and impaired habituation to…”
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Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy by Hubbard, Jacqueline A., Szu, Jenny I., Yonan, Jennifer M., Binder, Devin K.

“…Astrocytes regulate extracellular glutamate and water homeostasis through the astrocyte-specific membrane proteins glutamate transporter-1 (GLT1) and…”
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Regulation of Synaptosomal GLT-1 and GLAST during Epileptogenesis by Peterson, Allison R., Binder, Devin K.

“…Astrocytes regulate extracellular glutamate homeostasis in the central nervous system through the Na+-dependent glutamate transporters glutamate transporter-1…”
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The Perineuronal 'Safety' Net? Perineuronal Net Abnormalities in Neurological Disorders by Wen, Teresa H, Binder, Devin K, Ethell, Iryna M, Razak, Khaleel A

“…Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially ensheath parvalbumin (PV) expressing interneurons. Converging evidence…”
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Astrocyte Glutamate Uptake and Signaling as Novel Targets for Antiepileptogenic Therapy by Peterson, Allison R., Binder, Devin K.

“…Astrocytes regulate and respond to extracellular glutamate levels in the central nervous system (CNS) via the Na + -dependent glutamate transporters glutamate…”
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GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii by David, Clément N, Frias, Elma S, Szu, Jenny I, Vieira, Philip A, Hubbard, Jacqueline A, Lovelace, Jonathan, Michael, Marena, Worth, Danielle, McGovern, Kathryn E, Ethell, Iryna M, Stanley, B Glenn, Korzus, Edward, Fiacco, Todd A, Binder, Devin K, Wilson, Emma H

“…The immune privileged nature of the CNS can make it vulnerable to chronic and latent infections. Little is known about the effects of lifelong brain…”
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Aquaporin-4 water channels and synaptic plasticity in the hippocampus by Scharfman, Helen E., Binder, Devin K.

“…•Astrocytes participate in synaptic plasticity.•Mice deficient in aquaporin-4 (AQP4) display deficits in synaptic plasticity.•Mice deficient in aquaporin-4…”
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Functional changes in astroglial cells in epilepsy by Binder, Devin K., Steinhäuser, Christian

“…Epilepsy comprises a group of disorders characterized by the periodic occurrence of seizures, and pathologic specimens from patients with temporal lobe…”
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Turning down the volume: Astrocyte volume change in the generation and termination of epileptic seizures by Murphy, Thomas R, Binder, Devin K, Fiacco, Todd A

“…Abstract Approximately 1% of the global population suffers from epilepsy, a class of disorders characterized by recurrent and unpredictable seizures. Of these…”
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Aquaporin-4 and epilepsy by Binder, Devin K., Nagelhus, Erlend A., Ottersen, Ole Petter

“…Recent studies have implicated glial cells in modulation of synaptic transmission, so it is plausible that glial cells may have a functional role in the…”
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Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target by Peterson, Allison R, Binder, Devin K

“…Glutamate transporter-1 (GLT-1) is a Na -dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central…”
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Acute pharmacological inhibition of matrix metalloproteinase‐9 activity during development restores perineuronal net formation and normalizes auditory processing in Fmr1 KO mice by Pirbhoy, Patricia S., Rais, Maham, Lovelace, Jonathan W., Woodard, Walker, Razak, Khaleel A., Binder, Devin K., Ethell, Iryna M.

“…Individuals with Fragile X Syndrome (FXS) and autism spectrum disorder (ASD) exhibit cognitive impairments, social deficits, increased anxiety, and sensory…”
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Focused ultrasound and other lesioning in the treatment of tremor by Binder, Devin K., Shah, Binit B., Elias, W. Jeffrey

“…There has been a long history of lesioning procedures to treat tremor associated with both essential tremor (ET) and Parkinson's disease (PD). These include…”
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Multielectrode array analysis of EEG biomarkers in a mouse model of Fragile X Syndrome by Jonak, Carrie R., Lovelace, Jonathan W., Ethell, Iryna M., Razak, Khaleel A., Binder, Devin K.

“…Fragile X Syndrome (FXS) is a leading known genetic cause of intellectual disability with symptoms that include increased anxiety and social and sensory…”
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The Role of Astrocytic Aquaporin-4 in Synaptic Plasticity and Learning and Memory by Szu, Jenny I, Binder, Devin K

“…Aquaporin-4 (AQP4) is the predominant water channel expressed by astrocytes in the central nervous system (CNS). AQP4 is widely expressed throughout the brain,…”
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Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy by Szu, Jenny I., Binder, Devin K.

“…Epilepsy is a chronic brain disorder characterized by unprovoked seizures. Mechanisms underlying seizure activity have been intensely investigated. Alterations…”
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Astrocytes: Stars of the Sacred Disease by Binder, Devin K.

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