Search Results - "Binder, David C."

Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy by Zhai, Lijie, Spranger, Stefani, Binder, David C, Gritsina, Galina, Lauing, Kristen L, Giles, Francis J, Wainwright, Derek A

“…Indoleamine 2, 3-dioxygenase 1 (IDO1), IDO2, and tryptophan 2, 3-dioxygenase (TDO) comprise a family of enzymes that catalyze the first- and rate-limiting step…”
Get full text

Relapse or Eradication of Cancer Is Predicted by Peptide-Major Histocompatibility Complex Affinity by Engels, Boris, Engelhard, Victor H., Sidney, John, Sette, Alessandro, Binder, David C., Liu, Rebecca B., Kranz, David M., Meredith, Stephen C., Rowley, Donald A., Schreiber, Hans

“…Cancers often relapse after adoptive therapy, even though specific T cells kill cells from the same cancer efficiently in vitro. We found that tumor…”
Get full text

Immunotherapy for cancer in the central nervous system: Current and future directions by Binder, David C., Davis, Andrew A., Wainwright, Derek A.

“…Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and still remains incurable. Although immunotherapeutic vaccination against GBM…”
Get full text

Non-tumor cell IDO1 predominantly contributes to enzyme activity and response to CTLA-4/PD-L1 inhibition in mouse glioblastoma by Zhai, Lijie, Ladomersky, Erik, Dostal, Carlos R, Lauing, Kristen, Swoap, Kathleen, Billingham, Leah K, Gritsina, Galina, Wu, Meijing, McCusker, Robert H, Binder, David C, Wainwright, Derek A

“…Highlights • Non-tumor cell IDO1 predominantly contributes to Kyn accumulation in mouse GBM. • Immune checkpoint blockade requires IDO1 for maximal survival…”
Get full text

Densely Granulated Murine NK Cells Eradicate Large Solid Tumors by LIU, Rebecca B, ENGELS, Boris, JABRI, Bana, SCHREIBER, Hans, ARINA, Ainhoa, SCHREIBER, Karin, HYJEK, Elizabeth, SCHIETINGER, Andrea, BINDER, David C, BUTZ, Eric, KRAUSZ, Thomas, ROWLEY, Donald A

“…Natural killer (NK) cells inhibit early stages of tumor formation, recurrence, and metastasis. Here, we show that NK cells can also eradicate large solid…”
Get full text

Commentary: preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma by Garg et al. (2017) by Zhai, Lijie, Ladomersky, Erik, Lauing, Kristen L., Wu, Meijing, Scholtens, Denise M., Savoor, Rohan, Zhang, Bin, Wu, Jennifer D., Horbinski, Craig, Lukas, Rimas V., Binder, David C., Wainwright, Derek A.

“…Preclinical modeling and gene expression analyses have yielded distinct observations for the role of immune checkpoint, IDO1, in glioblastoma (GBM)…”
Get full text

Infiltrating T Cells Increase IDO1 Expression in Glioblastoma and Contribute to Decreased Patient Survival by Zhai, Lijie, Ladomersky, Erik, Lauing, Kristen L, Wu, Meijing, Genet, Matthew, Gritsina, Galina, Győrffy, Balázs, Brastianos, Priscilla K, Binder, David C, Sosman, Jeffrey A, Giles, Francis J, James, Charles D, Horbinski, Craig, Stupp, Roger, Wainwright, Derek A

“…Indoleamine 2,3 dioxygenase 1 (IDO1) mediates potent immunosuppression in multiple preclinical models of cancer. However, the basis for elevated IDO1…”
Get full text

IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma by Ladomersky, Erik, Zhai, Lijie, Lenzen, Alicia, Lauing, Kristen L, Qian, Jun, Scholtens, Denise M, Gritsina, Galina, Sun, Xuebing, Liu, Ye, Yu, Fenglong, Gong, Wenfeng, Liu, Yong, Jiang, Beibei, Tang, Tristin, Patel, Ricky, Platanias, Leonidas C, James, C David, Stupp, Roger, Lukas, Rimas V, Binder, David C, Wainwright, Derek A

“…Glioblastoma is the most aggressive primary brain tumor in adults with a median survival of 15-20 months. Numerous approaches and novel therapeutics for…”
Get full text

Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors--letter by Binder, David C, Schreiber, Hans

Get full text

The Boosting Potential of Bacteria in Cancer Immunotherapy by Binder, David C, Wainwright, Derek A

“…Salmonella Typhimurium, engineered to express flagellin B, recently demonstrated unprecedented tumor control through a TLR-dependent mechanism. Here, we review…”
Get full text

Radiotherapy and immune checkpoint blockade: potential interactions and future directions by Binder, David C, Fu, Yang-Xin, Weichselbaum, Ralph R

“…Combining radiation and immune checkpoint blockade provides synergistic antitumor responses in animal models and a small subset of patients. New preclinical…”
Get full text

Impact of immunotherapy among patients with melanoma brain metastases managed with radiotherapy by Stokes, William A., Binder, David C., Jones, Bernard L., Oweida, Ayman J., Liu, Arthur K., Rusthoven, Chad G., Karam, Sana D.

“…Patients with melanoma brain metastases (MBM) have been excluded from trials evaluating immunotherapy in melanoma. As such, immunotherapy's role in MBM is…”
Get full text

Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium by Binder, David C, Arina, Ainhoa, Wen, Frank, Tu, Tony, Zhao, Ming, Hoffman, Robert M, Wainwright, Derek A, Schreiber, Hans

“…We recently reported that therapeutic vaccination with live tumor antigen-producing Salmonella typhimurium rescues dysfunctional endogenous T cell responses…”
Get full text

Adoptively transferred immune T cells eradicate established tumors despite cancer-induced immune suppression by Arina, Ainhoa, Schreiber, Karin, Binder, David C, Karrison, Theodore G, Liu, Rebecca B, Schreiber, Hans

“…Myeloid-derived CD11b(+)Gr1(+) suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) are considered a major obstacle for effective adoptive T cell…”
Get full text

Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma by Binder, David C., Ladomersky, Erik, Lenzen, Alicia, Zhai, Lijie, Lauing, Kristen L., Otto-Meyer, Sebastian D., Lukas, Rimas V., Wainwright, Derek A.

Get full text

IV Administered Gadodiamide Enters the Lumen of the Prostatic Glands: X-Ray Fluorescence Microscopy Examination of a Mouse Model by Mustafi, Devkumar, Gleber, Sophie-Charlotte, Ward, Jesse, Dougherty, Urszula, Zamora, Marta, Markiewicz, Erica, Binder, David C, Antic, Tatjana, Vogt, Stefan, Karczmar, Gregory S, Oto, Aytekin

“…Dynamic contrast-enhanced MRI (DCE-MRI) has become a standard component of multiparametric protocols for MRI examination of the prostate, and its use is…”
Get full text

Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer by Binder, David C, Engels, Boris, Arina, Ainhoa, Yu, Ping, Slauch, James M, Fu, Yang-Xin, Karrison, Theodore, Burnette, Byron, Idel, Christian, Zhao, Ming, Hoffman, Robert M, Munn, David H, Rowley, Donald A, Schreiber, Hans

“…Immunogenic tumors grow progressively even when heavily infiltrated by CD8(+) T cells. We investigated how to rescue CD8(+) T cell function in long-established…”
Get more information

Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro by Meliton, Angelo Y, Muñoz, Nilda M, Meliton, Lucille N, Binder, David C, Osan, Christopher M, Zhu, Xiangdong, Dudek, Steven M, Leff, Alan R

“…Cytosolic gIVaPLA2 is a critical enzyme in the generation of arachidonate metabolites and in induction of beta2-integrin adhesion in granulocytes. We…”
Get full text

High-affinity peptide-based anticancer vaccination to overcome resistance to immunostimulatory antibodies by Binder, David C, Schreiber, Hans

“…We tested how to eradicate long-established immunogenic tumors that were resistant to the monoclonal antibody-mediated blockade of PD-L1 (PD-1 ligand 1) and…”
Get full text

Improving vaccine efficacy against malignant glioma by Ladomersky, Erik, Genet, Matthew, Zhai, Lijie, Gritsina, Galina, Lauing, Kristen L., Lulla, Rishi R., Fangusaro, Jason, Lenzen, Alicia, Kumthekar, Priya, Raizer, Jeffrey J., Binder, David C., James, C. David, Wainwright, Derek A.

“…The effective treatment of adult and pediatric malignant glioma is a significant clinical challenge. In adults, glioblastoma (GBM) accounts for the majority of…”
Get full text