Search Results - "Binder, Christoph"

Humoral immunity in atherosclerosis and myocardial infarction: from B cells to antibodies by Porsch, Florentina, Mallat, Ziad, Binder, Christoph J

“…Abstract Immune mechanisms are critically involved in the pathogenesis of atherosclerosis and its clinical manifestations. Associations of specific antibody…”
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The role of B cells in atherosclerosis by Sage, Andrew P., Tsiantoulas, Dimitrios, Binder, Christoph J., Mallat, Ziad

“…The cardiovascular system is subject to hyperlipidaemic, inflammatory, and pro-oxidant stressors. Over time, these factors drive prevalent chronic diseases, of…”
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Innate sensing of oxidation-specific epitopes in health and disease by Binder, Christoph J., Papac-Milicevic, Nikolina, Witztum, Joseph L.

“…Key Points Oxidative stress results in the oxidative damage of membrane lipids, leading to the formation of neo-self epitopes, which are known as…”
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Role of Antibodies and Their Specificities in Atherosclerotic Cardiovascular Disease by Deroissart, Justine, Binder, Christoph J, Porsch, Florentina

“…Atherosclerosis is a lipid-driven chronic inflammatory disease that is modulated by innate and adaptive immunity including humoral immunity. Importantly,…”
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The multifaceted impact of complement on atherosclerosis by Kiss, Máté G., Binder, Christoph J.

“…As one of the cornerstones of innate immunity, the complement system has long been implicated in the pathogenesis of atherosclerosis. Growing evidence…”
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Autoimmune diseases and atherosclerotic cardiovascular disease by Porsch, Florentina, Binder, Christoph J.

“…Autoimmune diseases are associated with a dramatically increased risk of atherosclerotic cardiovascular disease and its clinical manifestations. The increased…”
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The innate immune response to products of phospholipid peroxidation by Weismann, David, Binder, Christoph J.

“…Lipid peroxidation occurs in the context of many physiological processes but is greatly increased in various pathological situations. A consequence of…”
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Impact of B-Cell–Targeted Therapies on Cardiovascular Disease by Porsch, Florentina, Binder, Christoph J

“…Atherosclerosis is a lipid-driven chronic inflammatory disease that is modulated by many immune cell subsets, including B cells. Therefore, targeting the…”
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Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel by Borén, Jan, Chapman, M John, Krauss, Ronald M, Packard, Chris J, Bentzon, Jacob F, Binder, Christoph J, Daemen, Mat J, Demer, Linda L, Hegele, Robert A, Nicholls, Stephen J, Nordestgaard, Børge G, Watts, Gerald F, Bruckert, Eric, Fazio, Sergio, Ference, Brian A, Graham, Ian, Horton, Jay D, Landmesser, Ulf, Laufs, Ulrich, Masana, Luis, Pasterkamp, Gerard, Raal, Frederick J, Ray, Kausik K, Schunkert, Heribert, Taskinen, Marja-Riitta, van de Sluis, Bart, Wiklund, Olov, Tokgozoglu, Lale, Catapano, Alberico L, Ginsberg, Henry N

“…Abstract…”
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B Cells and Humoral Immunity in Atherosclerosis by Tsiantoulas, Dimitrios, Diehl, Cody J, Witztum, Joseph L, Binder, Christoph J

“…Insights into the important contribution of inflammation and immune functions in the development and progression of atherosclerosis have greatly improved our…”
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Malondialdehyde epitopes as mediators of sterile inflammation by Busch, Clara J., Binder, Christoph J.

“…Enhanced lipid peroxidation occurs during oxidative stress and results in the generation of lipid peroxidation end products such as malondialdehyde (MDA),…”
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Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells by Puhm, Florian, Afonyushkin, Taras, Resch, Ulrike, Obermayer, Georg, Rohde, Manfred, Penz, Thomas, Schuster, Michael, Wagner, Gabriel, Rendeiro, Andre F., Melki, Imene, Kaun, Christoph, Wojta, Johann, Bock, Christoph, Jilma, Bernd, Mackman, Nigel, Boilard, Eric, Binder, Christoph J.

“…RATIONALE:Extracellular vesicles, including microvesicles, are increasingly recognized as important mediators in cardiovascular disease. The cargo and surface…”
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Mapping the functions of IgM antibodies in atherosclerotic cardiovascular disease by Deroissart, Justine, Binder, Christoph J.

“…IgM antibodies have gained much attention as risk markers of atherosclerotic cardiovascular disease, but the exact antigenic determinants and the full spectrum…”
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Targeting B Cells in Atherosclerosis: Closing the Gap From Bench to Bedside by Tsiantoulas, Dimitrios, Sage, Andrew P, Mallat, Ziad, Binder, Christoph J

“…Atherosclerotic plaque formation is strongly influenced by different arms of the immune system, including B lymphocytes. B cells are divided into 2 main…”
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Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice by Que, Xuchu, Hung, Ming-Yow, Yeang, Calvin, Gonen, Ayelet, Prohaska, Thomas A., Sun, Xiaoli, Diehl, Cody, Määttä, Antti, Gaddis, Dalia E., Bowden, Karen, Pattison, Jennifer, MacDonald, Jeffrey G., Ylä-Herttuala, Seppo, Mellon, Pamela L., Hedrick, Catherine C., Ley, Klaus, Miller, Yury I., Glass, Christopher K., Peterson, Kirk L., Binder, Christoph J., Tsimikas, Sotirios, Witztum, Joseph L.

“…Oxidized phospholipids (OxPL) are ubiquitous, are formed in many inflammatory tissues, including atherosclerotic lesions, and frequently mediate…”
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Can a single genetic variant explain residual cardiovascular risk by modifying NLRP3 expression? by Papac-Milicevic, Nikolina, Binder, Christoph J

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Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas by Zernecke, Alma, Winkels, Holger, Cochain, Clément, Williams, Jesse W., Wolf, Dennis, Soehnlein, Oliver, Robbins, Clint S., Monaco, Claudia, Park, Inhye, McNamara, Coleen A., Binder, Christoph J., Cybulsky, Myron I., Scipione, Corey A., Hedrick, Catherine C., Galkina, Elena V., Kyaw, Tin, Ghosheh, Yanal, Dinh, Huy Q., Ley, Klaus

“…The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9 single-cell RNA sequencing and 2 mass cytometry studies. In a…”
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Anti-Spike Protein Assays to Determine SARS-CoV-2 Antibody Levels: a Head-to-Head Comparison of Five Quantitative Assays by Perkmann, Thomas, Perkmann-Nagele, Nicole, Koller, Thomas, Mucher, Patrick, Radakovics, Astrid, Marculescu, Rodrig, Wolzt, Michael, Wagner, Oswald F, Binder, Christoph J, Haslacher, Helmuth

“…Reliable quantification of the antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly relevant, e.g., for identifying…”
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Natural IgM Antibodies Against Oxidation-Specific Epitopes by Binder, Christoph J

“…Introduction Natural antibodies (NAbs) are mostly antibodies of the IgM isotype with germline or close to germline encoded variable regions that provide them…”
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Lower your cholesterol early, and stick with it by Swirski, Filip K, Binder, Christoph J

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